Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi
Martín-Escolano, Rubén, Moreno-Viguri, Elsa, Santivañez-Veliz, Mery, Martin-Montes, Alvaro, Medina-Carmona, Encarnación, Paucar, Rocío, Marín, Clotilde, Azqueta, Amaya, Cirauqui, Nuria, Pey, Angel L, Pérez-Silanes, Silvia, Sánchez-Moreno, Manuel
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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Journal Article
An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment
Martín-Escolano, Javier, Marín, Clotilde, Rosales, María J., Tsaousis, Anastasios D., Medina-Carmona, Encarnación, Martín-Escolano, Rubén
Published in ACS infectious diseases (10.06.2022)
Published in ACS infectious diseases (10.06.2022)
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Journal Article
Chagas Disease: Current View of an Ancient and Global Chemotherapy Challenge
Martín-Escolano, Javier, Medina-Carmona, Encarnación, Martín-Escolano, Rubén
Published in ACS infectious diseases (13.11.2020)
Published in ACS infectious diseases (13.11.2020)
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Journal Article
Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands
Medina-Carmona, Encarnación, Palomino-Morales, Rogelio J., Fuchs, Julian E., Padín-Gonzalez, Esperanza, Mesa-Torres, Noel, Salido, Eduardo, Timson, David J., Pey, Angel L.
Published in Scientific reports (03.02.2016)
Published in Scientific reports (03.02.2016)
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Journal Article
Synthesis and Biological in vitro and in vivo Evaluation of 2‐(5‐Nitroindazol‐1‐yl)ethylamines and Related Compounds as Potential Therapeutic Alternatives for Chagas Disease
Martín‐Escolano, Rubén, Aguilera‐Venegas, Benjamín, Marín, Clotilde, Martín‐Montes, Álvaro, Martín‐Escolano, Javier, Medina‐Carmona, Encarnación, Arán, Vicente J., Sánchez‐Moreno, Manuel
Published in ChemMedChem (08.10.2018)
Published in ChemMedChem (08.10.2018)
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Journal Article
Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses
Medina-Carmona, Encarnación, Betancor-Fernández, Isabel, Santos, Jaime, Mesa-Torres, Noel, Grottelli, Silvia, Batlle, Cristina, Naganathan, Athi N, Oppici, Elisa, Cellini, Barbara, Ventura, Salvador, Salido, Eduardo, Pey, Angel L
Published in Human molecular genetics (01.01.2019)
Published in Human molecular genetics (01.01.2019)
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Journal Article
Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate
Medina-Carmona, Encarnación, Gutierrez-Rus, Luis I, Manssour-Triedo, Fadia, Newton, Matilda S, Gamiz-Arco, Gloria, Mota, Antonio J, Reiné, Pablo, Cuerva, Juan Manuel, Ortega-Muñoz, Mariano, Andrés-León, Eduardo, Ortega-Roldan, Jose Luis, Seelig, Burckhard, Ibarra-Molero, Beatriz, Sanchez-Ruiz, Jose M
Published in Molecular biology and evolution (04.03.2023)
Published in Molecular biology and evolution (04.03.2023)
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Journal Article
Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism
Medina-Carmona, Encarnación, Neira, Jose L., Salido, Eduardo, Fuchs, Julian E., Palomino-Morales, Rogelio, Timson, David J., Pey, Angel L.
Published in Scientific reports (14.03.2017)
Published in Scientific reports (14.03.2017)
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Journal Article
Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution
Medina-Carmona, Encarnación, Fuchs, Julian E, Gavira, Jose A, Mesa-Torres, Noel, Neira, Jose L, Salido, Eduardo, Palomino-Morales, Rogelio, Burgos, Miguel, Timson, David J, Pey, Angel L
Published in Human molecular genetics (15.09.2017)
Published in Human molecular genetics (15.09.2017)
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Journal Article
Synthesis and biological evaluation of new long-chain squaramides as anti-chagasic agents in the BALB/c mouse model
Martín-Escolano, Rubén, Marín, Clotilde, Vega, Manuel, Martin-Montes, Álvaro, Medina-Carmona, Encarnación, López, Carlos, Rotger, Carmen, Costa, Antonio, Sánchez-Moreno, Manuel
Published in Bioorganic & medicinal chemistry (01.03.2019)
Published in Bioorganic & medicinal chemistry (01.03.2019)
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Journal Article
Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability
Medina-Carmona, Encarnación, Rizzuti, Bruno, Martín-Escolano, Rubén, Pacheco-García, Juan Luis, Mesa-Torres, Noel, Neira, José L., Guzzi, Rita, Pey, Angel L.
Published in International journal of biological macromolecules (15.03.2019)
Published in International journal of biological macromolecules (15.03.2019)
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Journal Article
New polyamine drugs as more effective antichagas agents than benznidazole in both the acute and chronic phases
Martín-Escolano, Rubén, Molina-Carreño, Daniel, Delgado-Pinar, Estefanía, Martin-Montes, Álvaro, Clares, M. Paz, Medina-Carmona, Encarnación, Pitarch-Jarque, Javier, Martín-Escolano, Javier, Rosales, María José, García-España, Enrique, Sánchez-Moreno, Manuel, Marín, Clotilde
Published in European journal of medicinal chemistry (15.02.2019)
Published in European journal of medicinal chemistry (15.02.2019)
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Journal Article
The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase
Neira, José L., Medina-Carmona, Encarnación, Hernández-Cifre, José G., Montoliu-Gaya, Laia, Cámara-Artigás, Ana, Seffouh, Ilham, Gonnet, Florence, Daniel, Régis, Villegas, Sandra, de la Torre, José García, Pey, Angel L., Li, Fuchuan
Published in Biochimie (01.12.2016)
Published in Biochimie (01.12.2016)
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Journal Article
Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein
Olotu, Fisayo, Medina-Carmona, Encarnacion, Serrano-Sanchez, Angela, Ossa, Felipe, El-Hamdaoui, Abdelaziz, Bishop, Özlem Tastan, Ortega-Roldan, Jose L., Abdul-Salam, Vahitha B.
Published in Computational and structural biotechnology journal (01.01.2023)
Published in Computational and structural biotechnology journal (01.01.2023)
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Journal Article
Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands
Medina-Carmona, Encarnación, Palomino-Morales, Rogelio J., Fuchs, Julian E., Padín-Gonzalez, Esperanza, Mesa-Torres, Noel, Salido, Eduardo, Timson, David J., Pey, Angel L.
Published in Scientific reports (04.03.2016)
Published in Scientific reports (04.03.2016)
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Journal Article
A quantitative assay to study the lipid selectivity of membrane-associated systems using solution NMR
Medina-Carmona, Encarnacion, Varela, Lorena, Hendry, Alex C, Thompson, Gary S, White, Lisa J, Boles, Jessica E, Hiscock, Jennifer R, Ortega-Roldan, Jose L
Published in Chemical communications (Cambridge, England) (07.10.2020)
Published in Chemical communications (Cambridge, England) (07.10.2020)
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Journal Article
Structure-based discovery and in vitro validation of selective inhibitors of Chloride Intracellular Channel 4 protein
Olotu, Fisayo, Medina-Carmona, Encarnacion, El-Hamdaoui, Abdelaziz, Bishop, Ozlem Tastan, Ortega-Roldan, Jose L, Abdul-Salam, Vahitha B
Published in bioRxiv (22.04.2022)
Published in bioRxiv (22.04.2022)
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