A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism
Ganassi, Massimo, Mateju, Daniel, Bigi, Ilaria, Mediani, Laura, Poser, Ina, Lee, Hyun O., Seguin, Samuel J., Morelli, Federica F., Vinet, Jonathan, Leo, Giuseppina, Pansarasa, Orietta, Cereda, Cristina, Poletti, Angelo, Alberti, Simon, Carra, Serena
Published in Molecular cell (01.09.2016)
Published in Molecular cell (01.09.2016)
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Journal Article
BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes
Adriaenssens, Elias, Tedesco, Barbara, Mediani, Laura, Asselbergh, Bob, Crippa, Valeria, Antoniani, Francesco, Carra, Serena, Poletti, Angelo, Timmerman, Vincent
Published in Scientific reports (29.05.2020)
Published in Scientific reports (29.05.2020)
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Journal Article
Studying heat shock proteins through single-molecule mechanical manipulation
Choudhary, Dhawal, Mediani, Laura, Carra, Serena, Cecconi, Ciro
Published in Cell stress & chaperones (01.07.2020)
Published in Cell stress & chaperones (01.07.2020)
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Journal Article
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
Boczek, Edgar E, Fürsch, Julius, Niedermeier, Marie Laura, Jawerth, Louise, Jahnel, Marcus, Ruer-Gruß, Martine, Kammer, Kai-Michael, Heid, Peter, Mediani, Laura, Wang, Jie, Yan, Xiao, Pozniakovski, Andrej, Poser, Ina, Mateju, Daniel, Hubatsch, Lars, Carra, Serena, Alberti, Simon, Hyman, Anthony A, Stengel, Florian
Published in eLife (06.09.2021)
Published in eLife (06.09.2021)
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Journal Article
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor
Tiago, Tatiana, Hummel, Barbara, Morelli, Federica F., Basile, Valentina, Vinet, Jonathan, Galli, Veronica, Mediani, Laura, Antoniani, Francesco, Pomella, Silvia, Cassandri, Matteo, Garone, Maria Giovanna, Silvestri, Beatrice, Cimino, Marco, Cenacchi, Giovanna, Costa, Roberta, Mouly, Vincent, Poser, Ina, Yeger-Lotem, Esti, Rosa, Alessandro, Alberti, Simon, Rota, Rossella, Ben-Zvi, Anat, Sawarkar, Ritwick, Carra, Serena
Published in Cell death & disease (06.05.2021)
Published in Cell death & disease (06.05.2021)
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Journal Article
Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis
Gönczi, Mónika, Teixeira, João M. C., Barrera-Vilarmau, Susana, Mediani, Laura, Antoniani, Francesco, Nagy, Tamás Milán, Fehér, Krisztina, Ráduly, Zsolt, Ambrus, Viktor, Tőzsér, József, Barta, Endre, Kövér, Katalin E., Csernoch, László, Carra, Serena, Fuxreiter, Monika
Published in Nature communications (10.03.2023)
Published in Nature communications (10.03.2023)
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Journal Article
Protein products of nonstop mRNA disrupt nucleolar homeostasis
Davis, Zoe H., Mediani, Laura, Antoniani, Francesco, Vinet, Jonathan, Li, Shuangxi, Alberti, Simon, Lu, Bingwei, Holehouse, Alex S., Carra, Serena, Brandman, Onn
Published in Cell stress & chaperones (01.05.2021)
Published in Cell stress & chaperones (01.05.2021)
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Journal Article
Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function
Morelli, Federica F., Verbeek, Dineke S., Bertacchini, Jessika, Vinet, Jonathan, Mediani, Laura, Marmiroli, Sandra, Cenacchi, Giovanna, Nasi, Milena, De Biasi, Sara, Brunsting, Jeanette F., Lammerding, Jan, Pegoraro, Elena, Angelini, Corrado, Tupler, Rossella, Alberti, Simon, Carra, Serena
Published in Cell reports (Cambridge) (29.08.2017)
Published in Cell reports (Cambridge) (29.08.2017)
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Journal Article
BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes
Mediani, Laura, Galli, Veronica, Carrà, Arianna Dorotea, Bigi, Ilaria, Vinet, Jonathan, Ganassi, Massimo, Antoniani, Francesco, Tiago, Tatiana, Cimino, Marco, Mateju, Daniel, Cereda, Cristina, Pansarasa, Orietta, Alberti, Simon, Mandrioli, Jessica, Carra, Serena
Published in Cell stress & chaperones (01.11.2020)
Published in Cell stress & chaperones (01.11.2020)
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Journal Article
Heat Shock Proteins: Important Helpers for the Development, Maintenance and Regeneration of Skeletal Muscles
Pomella, Silvia, Cassandri, Matteo, Antoniani, Francesco, Crotti, Samuele, Mediani, Laura, Silvestri, Beatrice, Medici, Margherita, Rota, Rossella, Rosa, Alessandro, Carra, Serena
Published in Muscles (18.04.2023)
Published in Muscles (18.04.2023)
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Journal Article
Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia
Antoniani, Francesco, Cimino, Marco, Mediani, Laura, Vinet, Jonathan, Verde, Enza M., Secco, Valentina, Yamoah, Alfred, Tripathi, Priyanka, Aronica, Eleonora, Cicardi, Maria E., Trotti, Davide, Sterneckert, Jared, Goswami, Anand, Carra, Serena
Published in Cell death discovery (15.07.2023)
Published in Cell death discovery (15.07.2023)
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Journal Article
Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling
Mediani, Laura, Gibellini, Federica, Bertacchini, Jessika, Frasson, Chiara, Bosco, Raffaella, Accordi, Benedetta, Basso, Giuseppe, Bonora, Massimo, Calabrò, Maria Luisa, Mattiolo, Adriana, Sgarbi, Gianluca, Baracca, Alessandra, Pinton, Paolo, Riva, Giovanni, Rampazzo, Enrico, Petrizza, Luca, Prodi, Luca, Milani, Daniela, Luppi, Mario, Potenza, Leonardo, De Pol, Anto, Cocco, Lucio, Capitani, Silvano, Marmiroli, Sandra
Published in Oncotarget (02.02.2016)
Published in Oncotarget (02.02.2016)
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Journal Article
ALS and FTD: Where RNA metabolism meets protein quality control
Mandrioli, Jessica, Mediani, Laura, Alberti, Simon, Carra, Serena
Published in Seminars in cell & developmental biology (01.03.2020)
Published in Seminars in cell & developmental biology (01.03.2020)
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Journal Article
Granulostasis: Protein Quality Control of RNP Granules
Alberti, Simon, Mateju, Daniel, Mediani, Laura, Carra, Serena
Published in Frontiers in molecular neuroscience (27.03.2017)
Published in Frontiers in molecular neuroscience (27.03.2017)
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Journal Article
Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin
Mediani, Laura, Guillén‐Boixet, Jordina, Vinet, Jonathan, Franzmann, Titus M, Bigi, Ilaria, Mateju, Daniel, Carrà, Arianna D, Morelli, Federica F, Tiago, Tatiana, Poser, Ina, Alberti, Simon, Carra, Serena
Published in The EMBO journal (01.08.2019)
Published in The EMBO journal (01.08.2019)
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Journal Article
Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling
Mediani, Laura, Antoniani, Francesco, Galli, Veronica, Vinet, Jonathan, Carrà, Arianna Dorotea, Bigi, Ilaria, Tripathy, Vadreenath, Tiago, Tatiana, Cimino, Marco, Leo, Giuseppina, Amen, Triana, Kaganovich, Daniel, Cereda, Cristina, Pansarasa, Orietta, Mandrioli, Jessica, Tripathi, Priyanka, Troost, Dirk, Aronica, Eleonora, Buchner, Johannes, Goswami, Anand, Sterneckert, Jared, Alberti, Simon, Carra, Serena
Published in EMBO reports (05.05.2021)
Published in EMBO reports (05.05.2021)
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Journal Article
Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process
Choudhary, Dhawal, Mediani, Laura, Avellaneda, Mario J., Bjarnason, Sveinn, Alberti, Simon, Boczek, Edgar E., Heidarsson, Pétur O., Mossa, Alessandro, Carra, Serena, Tans, Sander J., Cecconi, Ciro
Published in Journal of the American Chemical Society (19.07.2023)
Published in Journal of the American Chemical Society (19.07.2023)
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Journal Article
Missense mutation in ATXN2 gene (c.2860C > T) in an amyotrophic lateral sclerosis patient with aggressive disease phenotype
Ghezzi, Andrea, Martinelli, Ilaria, Carra, Serena, Mediani, Laura, Zucchi, Elisabetta, Simonini, Cecilia, Gianferrari, Giulia, Fini, Nicola, Cereda, Cristina, Gellera, Cinzia, Pensato, Viviana, Mandrioli, Jessica
Published in Neurological sciences (01.10.2022)
Published in Neurological sciences (01.10.2022)
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Journal Article
The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression
Bertacchini, Jessika, Beretti, Francesca, Cenni, Vittoria, Guida, Marianna, Gibellini, Federica, Mediani, Laura, Marin, Oriano, Maraldi, Nadir M, de Pol, Anto, Lattanzi, Giovanna, Cocco, Lucio, Marmiroli, Sandra
Published in The FASEB journal (01.06.2013)
Published in The FASEB journal (01.06.2013)
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