PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
Leone, Teresa C, Lehman, John J, Finck, Brian N, Schaeffer, Paul J, Wende, Adam R, Boudina, Sihem, Courtois, Michael, Wozniak, David F, Sambandam, Nandakumar, Bernal-Mizrachi, Carlos, Chen, Zhouji, Holloszy, John O, Medeiros, Denis M, Schmidt, Robert E, Saffitz, Jeffrey E, Abel, E Dale, Semenkovich, Clay F, Kelly, Daniel P
Published in PLoS biology (01.04.2005)
Published in PLoS biology (01.04.2005)
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β-carotene oxygenase 2 deficiency-triggered mitochondrial oxidative stress promotes low-grade inflammation and metabolic dysfunction
Wu, Lei, Lu, Peiran, Guo, Xin, Song, Kun, Lyu, Yi, Bothwell, James, Wu, Jinglong, Hawkins, Olivia, Clarke, Stephen L., Lucas, Edralin A., Smith, Brenda J., Chowanadisai, Winyoo, Hartson, Steve D., Ritchey, Jerry W., Wang, Weiqun, Medeiros, Denis M., Li, Shitao, Lin, Dingbo
Published in Free radical biology & medicine (20.02.2021)
Published in Free radical biology & medicine (20.02.2021)
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Molecular aspects of β, β-carotene-9′, 10′-oxygenase 2 in carotenoid metabolism and diseases
Wu, Lei, Guo, Xin, Wang, Weiqun, Medeiros, Denis M, Clarke, Stephen L, Lucas, Edralin A, Smith, Brenda J, Lin, Dingbo
Published in Experimental biology and medicine (Maywood, N.J.) (01.11.2016)
Published in Experimental biology and medicine (Maywood, N.J.) (01.11.2016)
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Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-α/PGC-1α gene regulatory pathway
DUNCAN, Jennifer G, FONG, Juliet L, MEDEIROS, Denis M, FINCK, Brian N, KELLY, Daniel P
Published in Circulation (New York, N.Y.) (20.02.2007)
Published in Circulation (New York, N.Y.) (20.02.2007)
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The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells
Dissmore, Tixieanna, Seye, Cheikh I, Medeiros, Denis M, Weisman, Gary A, Bardford, Barry, Mamedova, Laman
Published in Atherosclerosis (01.09.2016)
Published in Atherosclerosis (01.09.2016)
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Lack of β, β‐carotene‐9′, 10′‐oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice
Wu, Lei, Guo, Xin, Hartson, Steven D., Davis, Mary Abby, He, Hui, Medeiros, Denis M., Wang, Weiqun, Clarke, Stephen L., Lucas, Edralin A., Smith, Brenda J., Lintig, Johannes, Lin, Dingbo
Published in Molecular nutrition & food research (01.05.2017)
Published in Molecular nutrition & food research (01.05.2017)
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Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus
Wu, Lei, Guo, Xin, Wong, Siau Yen, Lu, Peiran, Hartson, Steven D., Medeiros, Denis M., Wang, Weiqun, Clarke, Stephen L., Lucas, Edralin A., Smith, Brenda J., Chowanadisai, Winyoo, Lin, Dingbo
Published in The Journal of nutritional biochemistry (01.02.2021)
Published in The Journal of nutritional biochemistry (01.02.2021)
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Journal Article
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
Leone, Teresa C, Lehman, John J, Finck, Brian N, Schaeffer, Paul J, Wende, Adam R, Boudina, Sihem, Courtois, Michael, Wozniak, David F, Sambandam, Nandakumar, Bernal-Mizrachi, Carlos, Chen, Zhouji, O. Holloszy, John, Medeiros, Denis M, Schmidt, Robert E, Saffitz, Jeffrey E, Abel, E. Dale, Semenkovich, Clay F, Kelly, Daniel P
Published in PLoS biology (01.04.2005)
Published in PLoS biology (01.04.2005)
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Ablation of β,β-carotene-9′,10′-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice
Guo, Xin, Wu, Lei, Lyu, Yi, Chowanadisai, Winyoo, Clarke, Stephen L., Lucas, Edralin A., Smith, Brenda J., He, Hui, Wang, Weiqun, Medeiros, Denis M., Lin, Dingbo
Published in The Journal of nutritional biochemistry (01.08.2017)
Published in The Journal of nutritional biochemistry (01.08.2017)
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Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice
Wu, Lei, Guo, Xin, Lyu, Yi, Clarke, Stephen L., Lucas, Edralin A., Smith, Brenda J., Hildebrand, Deana, Wang, Weiqun, Medeiros, Denis M., Shen, Xinchun, Lin, Dingbo
Published in Scientific reports (07.11.2017)
Published in Scientific reports (07.11.2017)
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