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Published in Scientific reports (17.05.2022)
Published in Scientific reports (17.05.2022)
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Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
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Published in EMBO molecular medicine (01.12.2019)
Published in EMBO molecular medicine (01.12.2019)
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The W101C KCNJ5 Mutation Induces Slower Pacing by Constitutively Active GIRK Channels in hiPSC-Derived Cardiomyocytes
Kayser, Anne, Dittmann, Sven, Šarić, Tomo, Mearini, Giulia, Verkerk, Arie O., Schulze-Bahr, Eric
Published in International journal of molecular sciences (18.10.2023)
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Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice
Mearini, Giulia, Stimpel, Doreen, Geertz, Birgit, Weinberger, Florian, Krämer, Elisabeth, Schlossarek, Saskia, Mourot-Filiatre, Julia, Stoehr, Andrea, Dutsch, Alexander, Wijnker, Paul J. M., Braren, Ingke, Katus, Hugo A., Müller, Oliver J., Voit, Thomas, Eschenhagen, Thomas, Carrier, Lucie
Published in Nature communications (02.12.2014)
Published in Nature communications (02.12.2014)
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Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue
Wijnker, Paul J.M, Friedrich, Felix W, Dutsch, Alexander, Reischmann, Silke, Eder, Alexandra, Vollert-Mannhardt, Ingra, Mearini, Giulia, Eschenhagen, Thomas, van der Velden, Jolanda, Carrier, Lucie
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Published in Journal of molecular and cellular cardiology (01.08.2016)
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Generation of a patient-specific hiPS cell line with heterozygous GNB2 mutation (UKMi003-A) causative for human sinus node dysfunction and a corresponding CRISPR/Cas9-corrected isogenic control (UKMi004-A)
Kayser, Anne, Dittmann, Sven, Hamidi, Jassin, Laufer, Sandra D., Krampe, Ramona, Mearini, Giulia, Hansen, Arne, Schulze-Bahr, Eric
Published in Stem cell research (01.08.2024)
Published in Stem cell research (01.08.2024)
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Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes
Prondzynski, Maksymilian, Krämer, Elisabeth, Laufer, Sandra D., Shibamiya, Aya, Pless, Ole, Flenner, Frederik, Müller, Oliver J., Münch, Julia, Redwood, Charles, Hansen, Arne, Patten, Monica, Eschenhagen, Thomas, Mearini, Giulia, Carrier, Lucie
Published in Molecular therapy. Nucleic acids (16.06.2017)
Published in Molecular therapy. Nucleic acids (16.06.2017)
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Endothelin‐1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy–Induced Pluripotent Stem Cell–Derived Cardiomyocytes
Tanaka, Atsushi, Yuasa, Shinsuke, Mearini, Giulia, Egashira, Toru, Seki, Tomohisa, Kodaira, Masaki, Kusumoto, Dai, Kuroda, Yusuke, Okata, Shinichiro, Suzuki, Tomoyuki, Inohara, Taku, Arimura, Takuro, Makino, Shinji, Kimura, Kensuke, Kimura, Akinori, Furukawa, Tetsushi, Carrier, Lucie, Node, Koichi, Fukuda, Keiichi
Published in Journal of the American Heart Association (11.11.2014)
Published in Journal of the American Heart Association (11.11.2014)
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Nonsense-Mediated mRNA Decay and Ubiquitin–Proteasome System Regulate Cardiac Myosin-Binding Protein C Mutant Levels in Cardiomyopathic Mice
Vignier, Nicolas, Schlossarek, Saskia, Fraysse, Bodvael, Mearini, Giulia, Krämer, Elisabeth, Pointu, Hervé, Mougenot, Nathalie, Guiard, Josiane, Reimer, Rudolph, Hohenberg, Heinrich, Schwartz, Ketty, Vernet, Muriel, Eschenhagen, Thomas, Carrier, Lucie
Published in Circulation research (31.07.2009)
Published in Circulation research (31.07.2009)
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Serum Matrix Metalloproteinases as Quantitative Biomarkers for Myocardial Fibrosis and Sudden Cardiac Death Risk Stratification in Patients With Hypertrophic Cardiomyopathy
Münch, Julia, MD, Avanesov, Maxim, MD, Bannas, Peter, MD, Säring, Dennis, PhD, Krämer, Elisabeth, Mearini, Giulia, PhD, Carrier, Lucie, PhD, Suling, Anna, PhD, Lund, Gunnar, MD, Patten, Monica, MD
Published in Journal of cardiac failure (01.10.2016)
Published in Journal of cardiac failure (01.10.2016)
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Rescue of cardiomyopathy through U7snRNA‐mediated exon skipping in Mybpc3‐targeted knock‐in mice
Gedicke‐Hornung, Christina, Behrens‐Gawlik, Verena, Reischmann, Silke, Geertz, Birgit, Stimpel, Doreen, Weinberger, Florian, Schlossarek, Saskia, Précigout, Guillaume, Braren, Ingke, Eschenhagen, Thomas, Mearini, Giulia, Lorain, Stéphanie, Voit, Thomas, Dreyfus, Patrick A., Garcia, Luis, Carrier, Lucie
Published in EMBO molecular medicine (01.07.2013)
Published in EMBO molecular medicine (01.07.2013)
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Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
Prondzynski, Maksymilian, Lemoine, Marc D, Zech, Antonia TL, Horváth, András, Di Mauro, Vittoria, Koivumäki, Jussi T, Kresin, Nico, Busch, Josefine, Krause, Tobias, Krämer, Elisabeth, Schlossarek, Saskia, Spohn, Michael, Friedrich, Felix W, Münch, Julia, Laufer, Sandra D, Redwood, Charles, Volk, Alexander E, Hansen, Arne, Mearini, Giulia, Catalucci, Daniele, Meyer, Christian, Christ, Torsten, Patten, Monica, Eschenhagen, Thomas, Carrier, Lucie
Published in EMBO molecular medicine (08.08.2022)
Published in EMBO molecular medicine (08.08.2022)
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Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue
Kresin, Nico, Stücker, Sabrina, Krämer, Elisabeth, Flenner, Frederik, Mearini, Giulia, Münch, Julia, Patten, Monica, Redwood, Charles, Carrier, Lucie, Friedrich, Felix W
Published in Frontiers in physiology (28.03.2019)
Published in Frontiers in physiology (28.03.2019)
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Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms
Mearini, Giulia, Gedicke, Christina, Schlossarek, Saskia, Witt, Christian C., Krämer, Elisabeth, Cao, Peirang, Gomes, Marcelo D., Lecker, Stewart H., Labeit, Siegfried, Willis, Monte S., Eschenhagen, Thomas, Carrier, Lucie
Published in Cardiovascular research (15.01.2010)
Published in Cardiovascular research (15.01.2010)
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Generation of bi-allelic MYBPC3 truncating mutant and isogenic control from an iPSC line of a patient with hypertrophic cardiomyopathy
Warnecke, Nele, Ulmer, Bärbel M., Laufer, Sandra D., Shibamiya, Aya, Krämer, Elisabeth, Neuber, Christiane, Hanke, Sophia, Behrens, Charlotta, Loos, Malte, Münch, Julia, Kühnisch, Jirko, Klaassen, Sabine, Eschenhagen, Thomas, Patten-Hamel, Monica, Carrier, Lucie, Mearini, Giulia
Published in Stem cell research (01.08.2021)
Published in Stem cell research (01.08.2021)
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ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes
Zech, Antonia T. L., Prondzynski, Maksymilian, Singh, Sonia R., Pietsch, Niels, Orthey, Ellen, Alizoti, Erda, Busch, Josefine, Madsen, Alexandra, Behrens, Charlotta S., Meyer-Jens, Moritz, Mearini, Giulia, Lemoine, Marc D., Krämer, Elisabeth, Mosqueira, Diogo, Virdi, Sanamjeet, Indenbirken, Daniela, Depke, Maren, Salazar, Manuela Gesell, Völker, Uwe, Braren, Ingke, Pu, William T., Eschenhagen, Thomas, Hammer, Elke, Schlossarek, Saskia, Carrier, Lucie
Published in Cells (Basel, Switzerland) (02.09.2022)
Published in Cells (Basel, Switzerland) (02.09.2022)
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Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy
Mearini, Giulia, Stimpel, Doreen, Krämer, Elisabeth, Geertz, Birgit, Braren, Ingke, Gedicke-Hornung, Christina, Précigout, Guillaume, Müller, Oliver J, Katus, Hugo A, Eschenhagen, Thomas, Voit, Thomas, Garcia, Luis, Lorain, Stéphanie, Carrier, Lucie
Published in Molecular therapy. Nucleic acids (01.07.2013)
Published in Molecular therapy. Nucleic acids (01.07.2013)
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Effects of Chronic Atrial Fibrillation on Active and Passive Force Generation in Human Atrial Myofibrils
Belus, Alexandra, Piroddi, Nicoletta, Ferrantini, Cecilia, Tesi, Chiara, Cazorla, Olivier, Toniolo, Luana, Drost, Maurice, Mearini, Giulia, Carrier, Lucie, Rossi, Alessandra, Mugelli, Alessandro, Cerbai, Elisabetta, van der Velden, Jolanda, Poggesi, Corrado
Published in Circulation research (09.07.2010)
Published in Circulation research (09.07.2010)
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