Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease
Bürli, Roland W, Luckhurst, Christopher A, Aziz, Omar, Matthews, Kim L, Yates, Dawn, Lyons, Kathy. A, Beconi, Maria, McAllister, George, Breccia, Perla, Stott, Andrew J, Penrose, Stephen D, Wall, Michael, Lamers, Marieke, Leonard, Philip, Müller, Ilka, Richardson, Christine M, Jarvis, Rebecca, Stones, Liz, Hughes, Samantha, Wishart, Grant, Haughan, Alan F, O’Connell, Catherine, Mead, Tania, McNeil, Hannah, Vann, Julie, Mangette, John, Maillard, Michel, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
Get full text
Journal Article
Nanofiber-Based Delivery of Therapeutic Peptides to the Brain
Mazza, Mariarosa, Notman, Rebecca, Anwar, Jamshed, Rodger, Alison, Hicks, Matthew, Parkinson, Gary, McCarthy, Dave, Daviter, Tina, Moger, Julian, Garrett, Natalie, Mead, Tania, Briggs, Michael, Schätzlein, Andreas G, Uchegbu, Ijeoma F
Published in ACS nano (26.02.2013)
Published in ACS nano (26.02.2013)
Get full text
Journal Article
Dynamics of Aβ42 Reduction in Plasma, CSF and Brain of Rats Treated with the γ-Secretase Modulator, GSM-10h
Hawkins, Julie, Harrison, David C., Ahmed, Sharlin, Davis, Robert P., Chapman, Trevor, Marshall, Ian, Smith, Beverley, Mead, Tania L., Medhurst, Andrew, Giblin, Ged M.P., Hall, Adrian, Gonzalez, Maria I., Richardson, Jill, Hussain, Ishrut
Published in Neuro-degenerative diseases (2011)
Published in Neuro-degenerative diseases (2011)
Get full text
Journal Article
TASTPM Mice Expressing Amyloid Precursor Protein and Presenilin-1 Mutant Transgenes Are Sensitive to γ-Secretase Modulation and Amyloid-β42 Lowering by GSM-10h
Hussain, Ishrut, Harrison, David C., Hawkins, Julie, Chapman, Trevor, Marshall, Ian, Facci, Laura, Ahmed, Sharlin, Brackenborough, Kim, Skaper, Stephen D., Mead, Tania L., Smith, Beverley B., Giblin, Gerard M.P., Hall, Adrian, Gonzalez, M. Isabel, Richardson, Jill C.
Published in Neuro-degenerative diseases (2011)
Published in Neuro-degenerative diseases (2011)
Get full text
Journal Article
Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists
TRANI, Giancarlo, BADDELEY, Stuart M, QUINN, Leann P, RAY, Alison M, RIVERS, Dean A, STEAN, Tania O, STEMP, Geoffrey, TRAIL, Brenda K, WITTY, David R, BRIGGS, Michael A, CHUANG, Tsu T, DEEKS, Nigel J, JOHNSON, Christopher N, KHAZRAGI, Abir A, MEAD, Tania L, MEDHURST, Andrew D, MILNER, Peter H
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Get full text
Journal Article
It is time for us all to embrace person-centred language for people in prison and people who were formerly in prison
Harney, Brendan L., Korchinski, Mo, Young, Pam, Scow, Marnie, Jack, Kathryn, Linsley, Paul, Bodkin, Claire, Brothers, Thomas D., Curtis, Michael, Higgs, Peter, Mead, Tania Sawicki, Hart, Aaron, Kilroy, Debbie, Bonn, Matthew, Bartlett, Sofia R.
Published in The International journal of drug policy (01.01.2022)
Published in The International journal of drug policy (01.01.2022)
Get full text
Journal Article
Lead Optimization toward Proof-of-Concept Tools for Huntington’s Disease within a 4‑(1H‑Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors
Wityak, John, McGee, Kevin F, Conlon, Michael P, Song, Ren Hua, Duffy, Bryan C, Clayton, Brent, Lynch, Michael, Wang, Gwen, Freeman, Emily, Haber, James, Kitchen, Douglas B, Manning, David D, Ismail, Jiffry, Khmelnitsky, Yuri, Michels, Peter, Webster, Jeff, Irigoyen, Macarena, Luche, Michele, Hultman, Monica, Bai, Mei, Kuok, IokTeng D, Newell, Ryan, Lamers, Marieke, Leonard, Philip, Yates, Dawn, Matthews, Kim, Ongeri, Lynette, Clifton, Steve, Mead, Tania, Deupree, Susan, Wheelan, Pat, Lyons, Kathy, Wilson, Claire, Kiselyov, Alex, Toledo-Sherman, Leticia, Beconi, Maria, Muñoz-Sanjuan, Ignacio, Bard, Jonathan, Dominguez, Celia
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
Get full text
Journal Article
Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048
Beconi, Maria G, Yates, Dawn, Lyons, Kathryn, Matthews, Kim, Clifton, Steve, Mead, Tania, Prime, Michael, Winkler, Dirk, O'Connell, Catherine, Walter, Daryl, Toledo-Sherman, Leticia, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Drug metabolism and disposition (01.12.2012)
Published in Drug metabolism and disposition (01.12.2012)
Get full text
Journal Article
Assessment of Chloroquine Treatment for Modulating Autophagy Flux in Brain of WT and HD Mice
Vodicka, Petr, Lim, Junghyun, Williams, Dana T., Kegel, Kimberly B., Chase, Kathryn, Park, Hyunsun, Marchionini, Deanna, Wilkinson, Stephen, Mead, Tania, Birch, Helen, Yates, Dawn, Lyons, Kathy, Dominguez, Celia, Beconi, Maria, Yue, Zhenyu, Aronin, Neil, DiFiglia, Marian
Published in Journal of Huntington's disease (2014)
Published in Journal of Huntington's disease (2014)
Get full text
Journal Article
Dynamics of A[beta]42 Reduction in Plasma, CSF and Brain of Rats Treated with the [gamma]-Secretase Modulator, GSM-10h
Hawkins, Julie, Harrison, David C, Ahmed, Sharlin, Davis, Robert P, Chapman, Trevor, Marshall, Ian, Smith, Beverley, Mead, Tania L, Medhurst, Andrew, Giblin, Ged M P, Hall, Adrian, Gonzalez, Maria I, Richardson, Jill, Hussain, Ishrut
Published in Neuro-degenerative diseases (01.08.2011)
Published in Neuro-degenerative diseases (01.08.2011)
Get full text
Journal Article
TASTPM Mice Expressing Amyloid Precursor Protein and Presenilin-1 Mutant Transgenes Are Sensitive to =[gamma]-Secretase Modulation and Amyloid-[beta]42 Lowering by GSM-10h
Hussain, Ishrut, Harrison, David C, Hawkins, Julie, Chapman, Trevor, Marshall, Ian, Facci, Laura, Ahmed, Sharlin, Brackenborough, Kim, Skaper, Stephen D, Mead, Tania L, Smith, Beverley B, Giblin, Gerard M P, Hall, Adrian, Gonzalez, M Isabel, Richardson, Jill C
Published in Neuro-degenerative diseases (01.12.2010)
Published in Neuro-degenerative diseases (01.12.2010)
Get full text
Journal Article
Tricyclic azepine derivatives as selective brain penetrant 5-HT sub(6) receptor antagonists
Trani, Giancarlo, Baddeley, Stuart M, Briggs, Michael A, Chuang, Tsu T, Deeks, Nigel J, Johnson, Christopher N, Khazragi, Abir A, Mead, Tania L, Medhurst, Andrew D, Milner, Peter H, Quinn, Leann P, Ray, Alison M, Rivers, Dean A, Stean, Tania O, Stemp, Geoffrey, Trail, Brenda K, Witty, David R
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
Get full text
Journal Article
Tricyclic azepine derivatives as selective brain penetrant 5-HT 6 receptor antagonists
Trani, Giancarlo, Baddeley, Stuart M., Briggs, Michael A., Chuang, Tsu T., Deeks, Nigel J., Johnson, Christopher N., Khazragi, Abir A., Mead, Tania L., Medhurst, Andrew D., Milner, Peter H., Quinn, Leann P., Ray, Alison M., Rivers, Dean A., Stean, Tania O., Stemp, Geoffrey, Trail, Brenda K., Witty, David R.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
Get full text
Journal Article