Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells
Böiers, Charlotta, Carrelha, Joana, Lutteropp, Michael, Luc, Sidinh, Green, Joanna C.A., Azzoni, Emanuele, Woll, Petter S., Mead, Adam J., Hultquist, Anne, Swiers, Gemma, Perdiguero, Elisa Gomez, Macaulay, Iain C., Melchiori, Luca, Luis, Tiago C., Kharazi, Shabnam, Bouriez-Jones, Tiphaine, Deng, Qiaolin, Pontén, Annica, Atkinson, Deborah, Jensen, Christina T., Sitnicka, Ewa, Geissmann, Frederic, Godin, Isabelle, Sandberg, Rickard, de Bruijn, Marella F.T.R., Jacobsen, Sten Eirik W.
Published in Cell stem cell (07.11.2013)
Published in Cell stem cell (07.11.2013)
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Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Giustacchini, Alice, Thongjuea, Supat, Barkas, Nikolaos, Woll, Petter S, Povinelli, Benjamin J, Booth, Christopher A G, Sopp, Paul, Norfo, Ruggiero, Rodriguez-Meira, Alba, Ashley, Neil, Jamieson, Lauren, Vyas, Paresh, Anderson, Kristina, Segerstolpe, Åsa, Qian, Hong, Olsson-Strömberg, Ulla, Mustjoki, Satu, Sandberg, Rickard, Jacobsen, Sten Eirik W, Mead, Adam J
Published in Nature medicine (01.06.2017)
Published in Nature medicine (01.06.2017)
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Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
Psaila, Bethan, Barkas, Nikolaos, Iskander, Deena, Roy, Anindita, Anderson, Stacie, Ashley, Neil, Caputo, Valentina S, Lichtenberg, Jens, Loaiza, Sandra, Bodine, David M, Karadimitris, Anastasios, Mead, Adam J, Roberts, Irene
Published in Genome Biology (03.05.2016)
Published in Genome Biology (03.05.2016)
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Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide
Harrison, Claire N., Mead, Adam J., Panchal, Anesh, Fox, Sonia, Yap, Christina, Gbandi, Emmanouela, Houlton, Aimee, Alimam, Samah, Ewing, Joanne, Wood, Marion, Chen, Frederick, Coppell, Jason, Panoskaltsis, Nicki, Knapper, Steven, Ali, Sahra, Hamblin, Angela, Scherber, Robyn, Dueck, Amylou C., Cross, Nicholas C.P., Mesa, Ruben, McMullin, Mary Frances
Published in Blood (26.10.2017)
Published in Blood (26.10.2017)
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Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs
O'Byrne, Sorcha, Elliott, Natalina, Rice, Siobhan, Buck, Gemma, Fordham, Nicholas, Garnett, Catherine, Godfrey, Laura, Crump, Nicholas T., Wright, Gary, Inglott, Sarah, Hua, Peng, Psaila, Bethan, Povinelli, Benjamin, Knapp, David J.H.F., Agraz-Doblas, Antonio, Bueno, Clara, Varela, Ignacio, Bennett, Phillip, Koohy, Hashem, Watt, Suzanne M., Karadimitris, Anastasios, Mead, Adam J., Ancliff, Phillip, Vyas, Paresh, Menendez, Pablo, Milne, Thomas A., Roberts, Irene, Roy, Anindita
Published in Blood (26.09.2019)
Published in Blood (26.09.2019)
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Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate
Grover, Amit, Mancini, Elena, Moore, Susan, Mead, Adam J, Atkinson, Deborah, Rasmussen, Kasper D, O'Carroll, Donal, Jacobsen, Sten Eirik W, Nerlov, Claus
Published in The Journal of experimental medicine (10.02.2014)
Published in The Journal of experimental medicine (10.02.2014)
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Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
Gooding, Sarah, Olechnowicz, Sam W. Z., Morris, Emma V., Armitage, Andrew E., Arezes, Joao, Frost, Joe, Repapi, Emmanouela, Edwards, James R., Ashley, Neil, Waugh, Craig, Gray, Nicola, Martinez-Hackert, Erik, Lim, Pei Jin, Pasricha, Sant-Rayn, Knowles, Helen, Mead, Adam J., Ramasamy, Karthik, Drakesmith, Hal, Edwards, Claire M.
Published in Nature communications (04.10.2019)
Published in Nature communications (04.10.2019)
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A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
Rice, Siobhan, Jackson, Thomas, Crump, Nicholas T., Fordham, Nicholas, Elliott, Natalina, O’Byrne, Sorcha, Fanego, Maria del Mar Lara, Addy, Dilys, Crabb, Trisevgeni, Dryden, Carryl, Inglott, Sarah, Ladon, Dariusz, Wright, Gary, Bartram, Jack, Ancliff, Philip, Mead, Adam J., Halsey, Christina, Roberts, Irene, Milne, Thomas A., Roy, Anindita
Published in Nature communications (25.11.2021)
Published in Nature communications (25.11.2021)
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Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development
Roy, Anindita, Wang, Guanlin, Iskander, Deena, O’Byrne, Sorcha, Elliott, Natalina, O’Sullivan, Jennifer, Buck, Gemma, Heuston, Elisabeth F., Wen, Wei Xiong, Meira, Alba Rodriguez, Hua, Peng, Karadimitris, Anastasios, Mead, Adam J., Bodine, David M., Roberts, Irene, Psaila, Bethan, Thongjuea, Supat
Published in Cell reports (Cambridge) (14.09.2021)
Published in Cell reports (Cambridge) (14.09.2021)
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The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission
Jeanpierre, Sandrine, Arizkane, Kawtar, Thongjuea, Supat, Grockowiak, Elodie, Geistlich, Kevin, Barral, Lea, Voeltzel, Thibault, Guillemin, Anissa, Gonin-Giraud, Sandrine, Gandrillon, Olivier, Nicolini, Franck-Emmanuel, Mead, Adam J, Maguer-Satta, Véronique, Lefort, Sylvain
Published in Haematologica (Roma) (01.01.2021)
Published in Haematologica (Roma) (01.01.2021)
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Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner
Luis, Tiago C., Barkas, Nikolaos, Carrelha, Joana, Giustacchini, Alice, Mazzi, Stefania, Norfo, Ruggiero, Wu, Bishan, Aliouat, Affaf, Guerrero, Jose A., Rodriguez-Meira, Alba, Bouriez-Jones, Tiphaine, Macaulay, Iain C., Jasztal, Maria, Zhu, Guangheng, Ni, Heyu, Robson, Matthew J., Blakely, Randy D., Mead, Adam J., Nerlov, Claus, Ghevaert, Cedric, Jacobsen, Sten Eirik W.
Published in Nature communications (28.09.2023)
Published in Nature communications (28.09.2023)
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Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21
Roy, Anindita, Cowan, Gillian, Mead, Adam J, Filippi, Sarah, Bohn, Georg, Chaidos, Aristeidis, Tunstall, Oliver, Chan, Jerry K. Y, Choolani, Mahesh, Bennett, Phillip, Kumar, Sailesh, Atkinson, Deborah, Wyatt-Ashmead, Josephine, Hu, Ming, Stumpf, Michael P. H, Goudevenou, Katerina, O'Connor, David, Chou, Stella T, Weiss, Mitchell J, Karadimitris, Anastasios, Jacobsen, Sten Eirik, Vyas, Paresh, Roberts, Irene
Published in Proceedings of the National Academy of Sciences - PNAS (23.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (23.10.2012)
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TARGET-Seq: A Protocol for High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing
Rodriguez-Meira, Alba, O’Sullivan, Jennifer, Rahman, Haseeb, Mead, Adam J.
Published in STAR protocols (18.12.2020)
Published in STAR protocols (18.12.2020)
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Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
Booth, Christopher A.G., Barkas, Nikolaos, Neo, Wen Hao, Boukarabila, Hanane, Soilleux, Elizabeth J., Giotopoulos, George, Farnoud, Noushin, Giustacchini, Alice, Ashley, Neil, Carrelha, Joana, Jamieson, Lauren, Atkinson, Deborah, Bouriez-Jones, Tiphaine, Prinjha, Rab K., Milne, Thomas A., Teachey, David T., Papaemmanuil, Elli, Huntly, Brian J.P., Jacobsen, Sten Eirik W., Mead, Adam J.
Published in Cancer cell (12.02.2018)
Published in Cancer cell (12.02.2018)
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A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors
Buono, Mario, Facchini, Raffaella, Matsuoka, Sahoko, Thongjuea, Supat, Waithe, Dominique, Luis, Tiago C., Giustacchini, Alice, Besmer, Peter, Mead, Adam J., Jacobsen, Sten Eirik W., Nerlov, Claus
Published in Nature cell biology (01.02.2016)
Published in Nature cell biology (01.02.2016)
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Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
Neo, Wen Hao, Meng, Yiran, Rodriguez-Meira, Alba, Fadlullah, Muhammad Z. H., Booth, Christopher A. G., Azzoni, Emanuele, Thongjuea, Supat, de Bruijn, Marella F. T. R., Jacobsen, Sten Eirik W., Mead, Adam J., Lacaud, Georges
Published in Nature communications (02.12.2021)
Published in Nature communications (02.12.2021)
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