The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis
Janes, Jeff, Young, Megan E., Chen, Emily, Rogers, Nicole H., Burgstaller-Muehlbacher, Sebastian, Hughes, Laura D., Love, Melissa S., Hull, Mitchell V., Kuhen, Kelli L., Woods, Ashley K., Joseph, Sean B., Petrassi, H. Michael, McNamara, Case W., Tremblay, Matthew S., Su, Andrew I., Schultz, Peter G., Chatterjee, Arnab K.
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2018)
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Journal Article
Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
Spillman, Natalie J., Allen, Richard J.W., McNamara, Case W., Yeung, Bryan K.S., Winzeler, Elizabeth A., Diagana, Thierry T., Kirk, Kiaran
Published in Cell host & microbe (13.02.2013)
Published in Cell host & microbe (13.02.2013)
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Journal Article
A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis
Love, Melissa S, Beasley, Federico C, Jumani, Rajiv S, Wright, Timothy M, Chatterjee, Arnab K, Huston, Christopher D, Schultz, Peter G, McNamara, Case W
Published in PLoS neglected tropical diseases (03.02.2017)
Published in PLoS neglected tropical diseases (03.02.2017)
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Journal Article
Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families
Bopp, Selina E R, Manary, Micah J, Bright, A Taylor, Johnston, Geoffrey L, Dharia, Neekesh V, Luna, Fabio L, McCormack, Susan, Plouffe, David, McNamara, Case W, Walker, John R, Fidock, David A, Denchi, Eros Lazzerini, Winzeler, Elizabeth A
Published in PLoS genetics (01.02.2013)
Published in PLoS genetics (01.02.2013)
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Journal Article
A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
Jumani, Rajiv S., Hasan, Muhammad M., Stebbins, Erin E., Donnelly, Liam, Miller, Peter, Klopfer, Connor, Bessoff, Kovi, Teixeira, Jose E., Love, Melissa S., McNamara, Case W., Huston, Christopher D.
Published in Nature communications (23.04.2019)
Published in Nature communications (23.04.2019)
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Journal Article
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.
Published in Nature communications (27.06.2019)
Published in Nature communications (27.06.2019)
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Journal Article
Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin
Hoepfner, Dominic, McNamara, Case W., Lim, Chek Shik, Studer, Christian, Riedl, Ralph, Aust, Thomas, McCormack, Susan L., Plouffe, David M., Meister, Stephan, Schuierer, Sven, Plikat, Uwe, Hartmann, Nicole, Staedtler, Frank, Cotesta, Simona, Schmitt, Esther K., Petersen, Frank, Supek, Frantisek, Glynne, Richard J., Tallarico, John A., Porter, Jeffrey A., Fishman, Mark C., Bodenreider, Christophe, Diagana, Thierry T., Movva, N. Rao, Winzeler, Elizabeth A.
Published in Cell host & microbe (14.06.2012)
Published in Cell host & microbe (14.06.2012)
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Journal Article
Cryptosporidium life cycle small molecule probing implicates translational repression and an Apetala 2 transcription factor in macrogamont differentiation
Hasan, Muhammad M, Mattice, Ethan B, Teixeira, José E, Jumani, Rajiv S, Stebbins, Erin E, Klopfer, Connor E, Franco, Sebastian E, Love, Melissa S, McNamara, Case W, Huston, Christopher D
Published in PLoS pathogens (01.04.2024)
Published in PLoS pathogens (01.04.2024)
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Journal Article
Antimalarial Peptide and Polyketide Natural Products from the Fijian Marine Cyanobacterium Moorea producens
Sweeney-Jones, Anne Marie, Gagaring, Kerstin, Antonova-Koch, Jenya, Zhou, Hongyi, Mojib, Nazia, Soapi, Katy, Skolnick, Jeffrey, McNamara, Case W, Kubanek, Julia
Published in Marine drugs (18.03.2020)
Published in Marine drugs (18.03.2020)
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Journal Article
Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening
Carucci, Mario, Duez, Julien, Tarning, Joel, García-Barbazán, Irene, Fricot-Monsinjon, Aurélie, Sissoko, Abdoulaye, Dumas, Lucie, Gamallo, Pablo, Beher, Babette, Amireault, Pascal, Dussiot, Michael, Dao, Ming, Hull, Mitchell V., McNamara, Case W., Roussel, Camille, Ndour, Papa Alioune, Sanz, Laura Maria, Gamo, Francisco Javier, Buffet, Pierre
Published in Nature communications (07.04.2023)
Published in Nature communications (07.04.2023)
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Journal Article
Drug Discovery for Cutaneous Leishmaniasis: A Review of Developments in the Past 15 Years
Corman, Hannah N, McNamara, Case W, Bakowski, Malina A
Published in Microorganisms (Basel) (23.11.2023)
Published in Microorganisms (Basel) (23.11.2023)
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Journal Article
Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis
Wilburn, Kaley M, Montague, Christine R, Qin, Bo, Woods, Ashley K, Love, Melissa S, McNamara, Case W, Schultz, Peter G, Southard, Teresa L, Huang, Lu, Petrassi, H Michael, VanderVen, Brian C
Published in PLoS pathogens (01.02.2022)
Published in PLoS pathogens (01.02.2022)
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Journal Article
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design
Harbut, Michael B., Patel, Bhumit A., Yeung, Bryan K. S., McNamara, Case W., Bright, A. Taylor, Ballard, Jaime, Supek, Frantisek, Golde, Todd E., Winzeler, Elizabeth A., Diagana, Thierry T., Greenbaum, Doron C.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
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Journal Article
Mutations in the P‑Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials
Flannery, Erika L, McNamara, Case W, Kim, Sang Wan, Kato, Tomoyo Sakata, Li, Fengwu, Teng, Christine H, Gagaring, Kerstin, Manary, Micah J, Barboa, Rachel, Meister, Stephan, Kuhen, Kelli, Vinetz, Joseph M, Chatterjee, Arnab K, Winzeler, Elizabeth A
Published in ACS chemical biology (20.02.2015)
Published in ACS chemical biology (20.02.2015)
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Journal Article
Protein target similarity is positive predictor of in vitro antipathogenic activity: a drug repurposing strategy for Plasmodium falciparum
Mogire, Reagan M., Miruka, Silviane A., Juma, Dennis W., McNamara, Case W., Andagalu, Ben, Burrows, Jeremy N., Chenu, Elodie, Duffy, James, Ogutu, Bernhards R., Akala, Hoseah M.
Published in Journal of cheminformatics (30.05.2024)
Published in Journal of cheminformatics (30.05.2024)
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Journal Article
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek
Published in PLoS pathogens (01.07.2015)
Published in PLoS pathogens (01.07.2015)
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Journal Article
Advances in Antiwolbachial Drug Discovery for Treatment of Parasitic Filarial Worm Infections
Bakowski, Malina A, McNamara, Case W
Published in Tropical medicine and infectious disease (18.07.2019)
Published in Tropical medicine and infectious disease (18.07.2019)
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Journal Article
Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor
Goldgof, Gregory M., Durrant, Jacob D., Ottilie, Sabine, Vigil, Edgar, Allen, Kenneth E., Gunawan, Felicia, Kostylev, Maxim, Henderson, Kiersten A., Yang, Jennifer, Schenken, Jake, LaMonte, Gregory M., Manary, Micah J., Murao, Ayako, Nachon, Marie, Murray, Rebecca, Prescott, Maximo, McNamara, Case W., Slayman, Carolyn W., Amaro, Rommie E., Suzuki, Yo, Winzeler, Elizabeth A.
Published in Scientific reports (13.06.2016)
Published in Scientific reports (13.06.2016)
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Journal Article
A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor
Nam, Tae-gyu, McNamara, Case W, Bopp, Selina, Dharia, Neekesh V, Meister, Stephan, Bonamy, Ghislain M. C, Plouffe, David M, Kato, Nobutaka, McCormack, Susan, Bursulaya, Badry, Ke, Hangjun, Vaidya, Akhil B, Schultz, Peter G, Winzeler, Elizabeth A
Published in ACS chemical biology (18.11.2011)
Published in ACS chemical biology (18.11.2011)
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Journal Article
M1 Protein Allows Group A Streptococcal Survival in Phagocyte Extracellular Traps through Cathelicidin Inhibition
Lauth, Xavier, von Köckritz-Blickwede, Maren, McNamara, Case W., Myskowski, Sandra, Zinkernagel, Annelies S., Beall, Bernard, Ghosh, Partho, Gallo, Richard L., Nizet, Victor
Published in Journal of innate immunity (01.01.2009)
Published in Journal of innate immunity (01.01.2009)
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