Novel Rapidly Diversifiable Antimicrobial RNA Polymerase Switch Region Inhibitors with Confirmed Mode of Action in Haemophilus influenzae
Buurman, Ed T, Foulk, Melinda A, Gao, Ning, Laganas, Valerie A, McKinney, David C, Moustakas, Demetri T, Rose, Jonathan A, Shapiro, Adam B, Fleming, Paul R
Published in Journal of Bacteriology (01.10.2012)
Published in Journal of Bacteriology (01.10.2012)
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Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli
Hameed P, Shahul, Manjrekar, Praveena, Chinnapattu, Murugan, Humnabadkar, Vaishali, Shanbhag, Gajanan, Kedari, Chaitanyakumar, Mudugal, Naina Vinay, Ambady, Anisha, de Jonge, Boudewijn L.M, Sadler, Claire, Paul, Beena, Sriram, Shubha, Kaur, Parvinder, Guptha, Supreeth, Raichurkar, Anandkumar, Fleming, Paul, Eyermann, Charles J, McKinney, David C, Sambandamurthy, Vasan K, Panda, Manoranjan, Ravishankar, Sudha
Published in ACS chemical biology (17.10.2014)
Published in ACS chemical biology (17.10.2014)
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Molecular basis for substrate recruitment to the PRMT5 methylosome
Mulvaney, Kathleen M., Blomquist, Christa, Acharya, Nischal, Li, Ruitong, Ranaghan, Matthew J., O’Keefe, Meghan, Rodriguez, Diego J., Young, Michael J., Kesar, Devishi, Pal, Debjani, Stokes, Matthew, Nelson, Alissa J., Jain, Sidharth S., Yang, Annan, Mullin-Bernstein, Zachary, Columbus, Josie, Bozal, Fazli K., Skepner, Adam, Raymond, Donald, LaRussa, Salvatore, McKinney, David C., Freyzon, Yelena, Baidi, Yossef, Porter, Dale, Aguirre, Andrew J., Ianari, Alessandra, McMillan, Brian, Sellers, William R.
Published in Molecular cell (02.09.2021)
Published in Molecular cell (02.09.2021)
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Journal Article
Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction
McKinney, David C, McMillan, Brian J, Ranaghan, Matthew J, Moroco, Jamie A, Brousseau, Merissa, Mullin-Bernstein, Zachary, O’Keefe, Meghan, McCarren, Patrick, Mesleh, Michael F, Mulvaney, Kathleen M, Robinson, Foxy, Singh, Ritu, Bajrami, Besnik, Wagner, Florence F, Hilgraf, Robert, Drysdale, Martin J, Campbell, Arthur J, Skepner, Adam, Timm, David E, Porter, Dale, Kaushik, Virendar K, Sellers, William R, Ianari, Alessandra
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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X‑ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein
Molodtsov, Vadim, Fleming, Paul R, Eyermann, Charles J, Ferguson, Andrew D, Foulk, Melinda A, McKinney, David C, Masse, Craig E, Buurman, Ed T, Murakami, Katsuhiko S
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
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Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain
Hill, Pamela J., Abibi, Ayome, Albert, Robert, Andrews, Beth, Gagnon, Moriah M., Gao, Ning, Grebe, Tyler, Hajec, Laurel I., Huang, Jian, Livchak, Stephania, Lahiri, Sushmita D., McKinney, David C., Thresher, Jason, Wang, Hongming, Olivier, Nelson, Buurman, Ed T.
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Journal Article
Selective Inhibitors of Bacterial t‑RNA-(N1G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain
Hill, Pamela J, Abibi, Ayome, Albert, Robert, Andrews, Beth, Gagnon, Moriah M, Gao, Ning, Grebe, Tyler, Hajec, Laurel I, Huang, Jian, Livchak, Stephania, Lahiri, Sushmita D, McKinney, David C, Thresher, Jason, Wang, Hongming, Olivier, Nelson, Buurman, Ed T
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Journal Article
The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability
Abibi, Ayome, Ferguson, Andrew D., Fleming, Paul R., Gao, Ning, Hajec, Laurel I., Hu, Jun, Laganas, Valerie A., McKinney, David C., McLeod, Sarah M., Prince, D.Bryan, Shapiro, Adam B., Buurman, Ed T.
Published in The Journal of biological chemistry (01.08.2014)
Published in The Journal of biological chemistry (01.08.2014)
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Journal Article
Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping
McKinney, David C, Eyermann, Charles J, Gu, Rong-Fang, Hu, Jun, Kazmirski, Steven L, Lahiri, Sushmita D, McKenzie, Andrew R, Shapiro, Adam B, Breault, Gloria
Published in ACS infectious diseases (08.07.2016)
Published in ACS infectious diseases (08.07.2016)
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Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase
Rose, Jonathan A., Lahiri, Sushmita D., McKinney, David C., Albert, Rob, Morningstar, Marshall L., Shapiro, Adam B., Fisher, Stewart L., Fleming, Paul R.
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens
McKinney, David C, Basarab, Gregory S, Cocozaki, Alexis I, Foulk, Melinda A, Miller, Matthew D, Ruvinsky, Anatoly M, Scott, Clay W, Thakur, Kumar, Zhao, Liang, Buurman, Ed T, Narayan, Sridhar
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
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Journal Article
4,5-Disubstituted 6‑Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine β‑Lactamase Inhibitors
McKinney, David C, Zhou, Fei, Eyermann, Charles J, Ferguson, Andrew D, Prince, D. Bryan, Breen, John, Giacobbe, Robert A, Lahiri, Sushmita, Verheijen, Jeroen C
Published in ACS infectious diseases (10.07.2015)
Published in ACS infectious diseases (10.07.2015)
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Journal Article
Illicit Transport via Dipeptide Transporter Dpp is Irrelevant to the Efficacy of Negamycin in Mouse Thigh Models of Escherichia coli Infection
McKinney, David C, Bezdenejnih-Snyder, Natascha, Farrington, Krista, Guo, Jian, McLaughlin, Robert E, Ruvinsky, Anatoly M, Singh, Renu, Basarab, Gregory S, Narayan, Sridhar, Buurman, Ed T
Published in ACS infectious diseases (08.05.2015)
Published in ACS infectious diseases (08.05.2015)
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Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform
Jiang, Wei, Shaw, Subrata, Rush, Jason, Dumont, Nancy, Kim, John, Singh, Ritu, Skepner, Adam, Khodier, Carol, Raffier, Cerise, Yan, Ni, Schluter, Cameron, Yu, Xiao, Szuchnicki, Mateusz, Sathappa, Murugappan, Kahn, Josephine, Sperling, Adam S, McKinney, David C, Gould, Alexandra E, Garvie, Colin W, Miller, Peter G
Published in bioRxiv : the preprint server for biology (21.05.2024)
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Published in bioRxiv : the preprint server for biology (21.05.2024)
Journal Article
Discovery of a first-in-class inhibitor of the PRMT5-substrate adaptor interaction
Mckinney, David C, Mcmillan, Brian J, Ranaghan, Matthew, Moroco, Jamie A, Brousseau, Merissa, Mullin-Bernstein, Zachary, Meghan O’keefe, Mccarren, Patrick, Mesleh, Michael F, Mulvaney, Kathleen M, Singh, Ritu, Bajrami, Besnik, Skepner, Adam, Timm, David E, Porter, Dale, Kaushik, Virendar K, Sellers, William R, Ianari, Alessandra
Published in bioRxiv (03.02.2021)
Published in bioRxiv (03.02.2021)
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