Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors
Reinbold, Raphael, Hvinden, Ingvild C., Rabe, Patrick, Herold, Ryan A., Finch, Alina, Wood, James, Morgan, Melissa, Staudt, Maximillian, Clifton, Ian J., Armstrong, Fraser A., McCullagh, James S. O., Redmond, Jo, Bardella, Chiara, Abboud, Martine I., Schofield, Christopher J.
Published in Nature communications (15.08.2022)
Published in Nature communications (15.08.2022)
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Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
Rack, Johannes Gregor Matthias, Liu, Qiang, Zorzini, Valentina, Voorneveld, Jim, Ariza, Antonio, Honarmand Ebrahimi, Kourosh, Reber, Julia M., Krassnig, Sarah C., Ahel, Dragana, van der Marel, Gijsbert A., Mangerich, Aswin, McCullagh, James S. O., Filippov, Dmitri V., Ahel, Ivan
Published in Nature communications (28.07.2021)
Published in Nature communications (28.07.2021)
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Unlocking the organic residues preserved in the corrosion from the Pewsey Hoard vessels
Carvalho, Luciana da Costa, Henry, Richard, McCullagh, James S. O., Pollard, A. Mark
Published in Scientific reports (09.12.2022)
Published in Scientific reports (09.12.2022)
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The influence of pesticides on the corrosion of a Roman bowl excavated in Kent, UK
Carvalho, Luciana da Costa, Goodburn-Brown, Dana, McCullagh, James S. O., Pollard, A. Mark
Published in Scientific reports (06.10.2022)
Published in Scientific reports (06.10.2022)
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Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1
Kulkarni, Anurag, Mateus, Manuel, Thinnes, Cyrille C., McCullagh, James S., Schofield, Christopher J., Taylor, Graham P., Bangham, Charles R.M.
Published in Cell chemical biology (16.11.2017)
Published in Cell chemical biology (16.11.2017)
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Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
John, Tobias, Saffoon, Nadia, Walsby-Tickle, John, Hester, Svenja S, Dingler, Felix A, Millington, Christopher L, McCullagh, James S. O, Patel, Ketan J, Hopkinson, Richard J, Schofield, Christopher J
Published in Chemical science (Cambridge) (14.02.2024)
Published in Chemical science (Cambridge) (14.02.2024)
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Metabolomics reveals diet-derived plant polyphenols accumulate in physiological bone
Alldritt, Isabelle, Whitham-Agut, Beatrice, Sipin, Miguel, Studholme, Jacob, Trentacoste, Angela, Tripp, Jennifer A., Cappai, Maria Grazia, Ditchfield, Peter, Devièse, Thibaut, Hedges, Robert E. M., McCullagh, James S. O.
Published in Scientific reports (29.05.2019)
Published in Scientific reports (29.05.2019)
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A Structural Model of a P450-Ferredoxin Complex from Orientation-Selective Double Electron–Electron Resonance Spectroscopy
Bowen, Alice M, Johnson, Eachan O. D, Mercuri, Francesco, Hoskins, Nicola J, Qiao, Ruihong, McCullagh, James S. O, Lovett, Janet E, Bell, Stephen G, Zhou, Weihong, Timmel, Christiane R, Wong, Luet Lok, Harmer, Jeffrey R
Published in Journal of the American Chemical Society (21.02.2018)
Published in Journal of the American Chemical Society (21.02.2018)
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Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells
Walsby-Tickle, John, Gannon, Joan, Hvinden, Ingvild, Bardella, Chiara, Abboud, Martine I., Nazeer, Areesha, Hauton, David, Pires, Elisabete, Cadoux-Hudson, Tom, Schofield, Christopher J., McCullagh, James S. O.
Published in Communications biology (20.05.2020)
Published in Communications biology (20.05.2020)
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Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation
Zois, Christos E., Hendriks, Anne M., Haider, Syed, Pires, Elisabete, Bridges, Esther, Kalamida, Dimitra, Voukantsis, Dimitrios, Lagerholm, B. Christoffer, Fehrmann, Rudolf S. N., den Dunnen, Wilfred F. A., Tarasov, Andrei I., Baba, Otto, Morris, John, Buffa, Francesca M., McCullagh, James S. O., Jalving, Mathilde, Harris, Adrian L.
Published in Cell death & disease (28.06.2022)
Published in Cell death & disease (28.06.2022)
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Comparing ion-pairing reagents and sample dissolution solvents for ion-pairing reversed-phase liquid chromatography/electrospray ionization mass spectrometry analysis of oligonucleotides
Gong, Lingzhi, McCullagh, James S. O.
Published in Rapid communications in mass spectrometry (28.02.2014)
Published in Rapid communications in mass spectrometry (28.02.2014)
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Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase
Sánchez-Fernández, Elena M, Tarhonskaya, Hanna, Al-Qahtani, Khalid, Hopkinson, Richard J, McCullagh, James S O, Schofield, Christopher J, Flashman, Emily
Published in Biochemical journal (15.01.2013)
Published in Biochemical journal (15.01.2013)
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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
Tarhonskaya, Hanna, Chowdhury, Rasheduzzaman, Leung, Ivanhoe K H, Loik, Nikita D, McCullagh, James S O, Claridge, Timothy D W, Schofield, Christopher J, Flashman, Emily
Published in Biochemical journal (01.11.2014)
Published in Biochemical journal (01.11.2014)
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Interferon‐stimulated gene products as regulators of central carbon metabolism
Ebrahimi, Kourosh H., Gilbert‐Jaramillo, Javier, James, William S., McCullagh, James S.O.
Published in The FEBS journal (01.06.2021)
Published in The FEBS journal (01.06.2021)
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Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
Liu, Shuang, Abboud, Martine I., John, Tobias, Mikhailov, Victor, Hvinden, Ingvild, Walsby-Tickle, John, Liu, Xiao, Pettinati, Ilaria, Cadoux-Hudson, Tom, McCullagh, James S. O., Schofield, Christopher J.
Published in Communications biology (01.11.2021)
Published in Communications biology (01.11.2021)
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Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response
Yalaz, Ceren, Bridges, Esther, Alham, Nasullah K, Zois, Christos E, Chen, Jianzhou, Bensaad, Karim, Miar, Ana, Pires, Elisabete, Muschel, Ruth J, McCullagh, James S O, Harris, Adrian L
Published in Cancer & metabolism (13.02.2024)
Published in Cancer & metabolism (13.02.2024)
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