Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors
McMahon, Róisín M., Premkumar, Lakshmanane, Martin, Jennifer L.
Published in Biochimica et biophysica acta (01.08.2014)
Published in Biochimica et biophysica acta (01.08.2014)
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Journal Article
P-glycoprotein inhibition: the past, the present and the future
Darby, Richard A J, Callaghan, Richard, McMahon, Roisin M
Published in Current drug metabolism (01.10.2011)
Published in Current drug metabolism (01.10.2011)
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Journal Article
Crystal structure and site-directed mutagenesis of circular bacteriocin plantacyclin B21AG reveals cationic and aromatic residues important for antimicrobial activity
Gor, Mian-Chee, Vezina, Ben, McMahon, Róisín M., King, Gordon J., Panjikar, Santosh, Rehm, Bernd H. A., Martin, Jennifer L., Smith, Andrew T.
Published in Scientific reports (15.10.2020)
Published in Scientific reports (15.10.2020)
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Journal Article
Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo
Ireland, Philip M, McMahon, Róisín M, Marshall, Laura E, Halili, Maria, Furlong, Emily, Tay, Stephanie, Martin, Jennifer L, Sarkar-Tyson, Mitali
Published in Antioxidants & redox signaling (01.02.2014)
Published in Antioxidants & redox signaling (01.02.2014)
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Journal Article
Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development
Christensen, Signe, Halili, Maria A, Strange, Natalie, Petit, Guillaume A, Huston, Wilhelmina M, Martin, Jennifer L, McMahon, Róisín M
Published in PloS one (19.09.2019)
Published in PloS one (19.09.2019)
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Journal Article
Structural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising Oxidoreductase
Christensen, Signe, Grøftehauge, Morten K, Byriel, Karl, Huston, Wilhelmina M, Furlong, Emily, Heras, Begoña, Martin, Jennifer L, McMahon, Róisín M
Published in PloS one (28.12.2016)
Published in PloS one (28.12.2016)
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Journal Article
Life inside and out: making and breaking protein disulfide bonds in Chlamydia
Christensen, Signe, McMahon, Róisín M., Martin, Jennifer L., Huston, Wilhelmina M.
Published in Critical reviews in microbiology (02.01.2019)
Published in Critical reviews in microbiology (02.01.2019)
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Journal Article
Identification and characterization of two drug‐like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA
Petit, Guillaume A., Mohanty, Biswaranjan, McMahon, Róisín M., Nebl, Stefan, Hilko, David H., Wilde, Karyn L., Scanlon, Martin J., Martin, Jennifer L., Halili, Maria A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.01.2022)
Published in Acta crystallographica. Section D, Biological crystallography. (01.01.2022)
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Journal Article
Opposing effects of HLA class I molecules in tuning autoreactive CD8 + T cells in multiple sclerosis
McMahon, Róisín M, Huygelen, Véronique, Jakobsen, Karen B, Etzensperger, Ruth, Jensen, Lise T, Bell, John I, Friis, Lone, Jones, E Yvonne, Fugger, Lars, Craner, Matthew J, Friese, Manuel A
Published in Nature Medicine (01.11.2008)
Published in Nature Medicine (01.11.2008)
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Journal Article
The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis
Wonderen, Jessica H., McMahon, Róisin M., O'Mara, Megan L., McDevitt, Christopher A., Thomson, Andrew J., Kerr, Ian D., MacMillan, Fraser, Callaghan, Richard
Published in The FEBS journal (01.05.2014)
Published in The FEBS journal (01.05.2014)
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Journal Article
Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1
Mohanty, Biswaranjan, Rimmer, Kieran, McMahon, Róisín M, Headey, Stephen J, Vazirani, Mansha, Shouldice, Stephen R, Coinçon, Mathieu, Tay, Stephanie, Morton, Craig J, Simpson, Jamie S, Martin, Jennifer L, Scanlon, Martin J
Published in PloS one (27.03.2017)
Published in PloS one (27.03.2017)
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Journal Article
Virulence of the Melioidosis Pathogen Burkholderia pseudomallei Requires the Oxidoreductase Membrane Protein DsbB
McMahon, Róisín M, Ireland, Philip M, Sarovich, Derek S, Petit, Guillaume, Jenkins, Christopher H, Sarkar-Tyson, Mitali, Currie, Bart J, Martin, Jennifer L
Published in Infection and immunity (01.05.2018)
Published in Infection and immunity (01.05.2018)
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Journal Article
NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei
Nebl, Stefan, Alwan, Wesam S., Williams, Martin L., Sharma, Gaurav, Taylor, Ashley, Doak, Bradley C., Wilde, Karyn L., McMahon, Róisín M., Halili, Maria A., Martin, Jennifer L., Capuano, Ben, Fenwick, R. Bryn, Mohanty, Biswaranjan, Scanlon, Martin J.
Published in Journal of biomolecular NMR (01.11.2020)
Published in Journal of biomolecular NMR (01.11.2020)
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Journal Article
Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials
Wang, Geqing, Mohanty, Biswaranjan, Williams, Martin L., Doak, Bradley C., Dhouib, Rabeb, Totsika, Makrina, McMahon, Róisín M., Sharma, Gaurav, Zheng, Dan, Bentley, Matthew R., Ka‐Yan Chin, Yanni, Horne, James, Chalmers, David K., Heras, Begoña, Scanlon, Martin J.
Published in ChemMedChem (18.03.2022)
Published in ChemMedChem (18.03.2022)
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Journal Article
Dissection of the multiple sclerosis associated DR2 haplotype
Etzensperger, Ruth, McMahon, Róisín M, Jones, E. Yvonne, Fugger, Lars
Published in Journal of autoimmunity (01.11.2008)
Published in Journal of autoimmunity (01.11.2008)
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Journal Article
Structure of HLA-A0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis
McMahon, Róisín M., Friis, Lone, Siebold, Christian, Friese, Manuel A., Fugger, Lars, Jones, E. Yvonne
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2011)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2011)
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Journal Article
Interrogating Fragments Using a Protein Thermal Shift Assay
McMahon, Róisín M., Scanlon, Martin J., Martin, Jennifer L.
Published in Australian journal of chemistry (2013)
Published in Australian journal of chemistry (2013)
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Journal Article
Membrane Protein Structures for Rational Antimicrobial Drug Design
Walden, Patricia M., McMahon, Roisin M., Archbold, Julia K.
Published in Australian journal of chemistry (01.01.2014)
Published in Australian journal of chemistry (01.01.2014)
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Journal Article
Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility
McMahon, Roisin M., Coinçon, Mathieu, Tay, Stephanie, Heras, Begoña, Morton, Craig J., Scanlon, Martin J., Martin, Jennifer L.
Published in Acta crystallographica. Section D, Biological crystallography. (01.12.2015)
Published in Acta crystallographica. Section D, Biological crystallography. (01.12.2015)
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Journal Article