The Opioid Crisis and the Future of Addiction and Pain Therapeutics
Coussens, Nathan P, Sittampalam, G Sitta, Jonson, Samantha G, Hall, Matthew D, Gorby, Heather E, Tamiz, Amir P, McManus, Owen B, Felder, Christian C, Rasmussen, Kurt
Published in The Journal of pharmacology and experimental therapeutics (01.11.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2019)
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Journal Article
'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies
Simkin, Dina, Ambrosi, Christina, Marshall, Kelly A, Williams, Luis A, Eisenberg, Jordyn, Gharib, Mennat, Dempsey, Graham T, George, Jr, Alfred L, McManus, Owen B, Kiskinis, Evangelos
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2022)
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2022)
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Journal Article
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels
Qu, Chunrong, Ding, Mingmin, Zhu, Yingmin, Lu, Yungang, Du, Juan, Miller, Melissa, Tian, Jinbin, Zhu, Jinmei, Xu, Jian, Wen, Meng, Er-Bu, AGA, Wang, Jule, Xiao, Yuling, Wu, Meng, McManus, Owen B, Li, Min, Wu, Jilin, Luo, Huai-Rong, Cao, Zhengyu, Shen, Bing, Wang, Hongbo, Zhu, Michael X, Hong, Xuechuan
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Journal Article
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology
Liu, Pin W, Zhang, Hongkang, Werley, Christopher A, Pichler, Monika, Ryan, Steven J, Lewarch, Caitlin L, Jacques, Jane, Grooms, Jennifer, Ferrante, Jean, Li, Guangde, Zhang, Dawei, Bremmer, Nate, Barnett, Adam, Chantre, Romina, Elder, Amy E, Cohen, Adam E, Williams, Luis A, Dempsey, Graham T, McManus, Owen B
Published in Pain (Amsterdam) (01.04.2024)
Published in Pain (Amsterdam) (01.04.2024)
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Journal Article
Simultaneous voltage and calcium imaging and optogenetic stimulation with high sensitivity and a wide field of view
Nguyen, Cuong, Upadhyay, Hansini, Murphy, Michael, Borja, Gabriel, Rozsahegyi, Emily J, Barnett, Adam, Brookings, Ted, McManus, Owen B, Werley, Christopher A
Published in Biomedical optics express (01.02.2019)
Published in Biomedical optics express (01.02.2019)
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Journal Article
Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice
Zhang, Yalan, Quraishi, Imran H, McClure, Heather, Williams, Luis A, Cheng, YungChih, Kale, Siddharth, Dempsey, Graham T, Agrawal, Sudhir, Gerber, David J, McManus, Owen B, Kaczmarek, Leonard K
Published in The FASEB journal (01.12.2021)
Published in The FASEB journal (01.12.2021)
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Journal Article
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels
Yu, Haibo, Lin, Zhihong, Mattmann, Margrith E., Zou, Beiyan, Terrenoire, Cecile, Zhang, Hongkang, Wu, Meng, McManus, Owen B., Kass, Robert S., Lindsley, Craig W., Hopkins, Corey R., Li, Min
Published in Proceedings of the National Academy of Sciences - PNAS (21.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (21.05.2013)
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Journal Article
Identification and optimization of 2‐aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
Zhu, Yingmin, Lu, Yungang, Qu, Chunrong, Miller, Melissa, Tian, Jinbin, Thakur, Dhananjay P, Zhu, Jinmei, Deng, Zixin, Hu, Xianming, Wu, Meng, McManus, Owen B, Li, Min, Hong, Xuechuan, Zhu, Michael X, Luo, Huai‐Rong
Published in British journal of pharmacology (01.07.2015)
Published in British journal of pharmacology (01.07.2015)
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Journal Article
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls
Simkin, Dina, Papakis, Vasileios, Bustos, Bernabe I., Ambrosi, Christina M., Ryan, Steven J., Baru, Valeriya, Williams, Luis A., Dempsey, Graham T., McManus, Owen B., Landers, John E., Lubbe, Steven J., George, Alfred L., Kiskinis, Evangelos
Published in Stem cell reports (12.04.2022)
Published in Stem cell reports (12.04.2022)
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Journal Article
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel
Zhang, Hongkang, Zou, Beiyan, Yu, Haibo, Moretti, Alessandra, Wang, Xiaoying, Yan, Wei, Babcock, Joseph J, Bellin, Milena, McManus, Owen B, Tomaselli, Gordon, Nan, Fajun, Laugwitz, Karl-Ludwig, Li, Min
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
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Journal Article
Probing Synaptic Signaling with Optogenetic Stimulation and Genetically Encoded Calcium Reporters
Borja, Gabriel B, Shroff, Himali, Upadhyay, Hansini, Liu, Pin W, Baru, Valeriya, Cheng, Yung-Chih, McManus, Owen B, Williams, Luis A, Dempsey, Graham T, Werley, Christopher A
Published in Methods in molecular biology (Clifton, N.J.) (2021)
Published in Methods in molecular biology (Clifton, N.J.) (2021)
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Journal Article
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold
Flaherty, Daniel P., Simpson, Denise S., Miller, Melissa, Maki, Brooks E., Zou, Beiyan, Shi, Jie, Wu, Meng, McManus, Owen B., Aubé, Jeffrey, Li, Min, Golden, Jennifer E.
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Journal Article
Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells
Borja, Gabriel B, Zhang, Hongkang, Harwood, Benjamin N, Jacques, Jane, Grooms, Jennifer, Chantre, Romina O, Zhang, Dawei, Barnett, Adam, Werley, Christopher A, Lu, Yang, Nagle, Steven F, McManus, Owen B, Dempsey, Graham T
Published in Frontiers in molecular neuroscience (04.07.2022)
Published in Frontiers in molecular neuroscience (04.07.2022)
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Journal Article
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker
Abbadie, Catherine, McManus, Owen B, Sun, Shu-Yu, Bugianesi, Randal M, Dai, Ge, Haedo, Rodolfo J, Herrington, James B, Kaczorowski, Gregory J, Smith, McHardy M, Swensen, Andrew M, Warren, Vivien A, Williams, Brande, Arneric, Stephen P, Eduljee, Cyrus, Snutch, Terrance P, Tringham, Elizabeth W, Jochnowitz, Nina, Liang, Annie, Euan MacIntyre, D, McGowan, Erin, Mistry, Shruti, White, Valerie V, Hoyt, Scott B, London, Clare, Lyons, Kathryn A, Bunting, Patricia B, Volksdorf, Sylvia, Duffy, Joseph L
Published in The Journal of pharmacology and experimental therapeutics (01.08.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2010)
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Journal Article
Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133
Wang, Hao-Ran, Wu, Meng, Yu, Haibo, Long, Shunyou, Stevens, Amy, Engers, Darren W, Sackin, Henry, Daniels, J Scott, Dawson, Eric S, Hopkins, Corey R, Lindsley, Craig W, Li, Min, McManus, Owen B
Published in ACS chemical biology (19.08.2011)
Published in ACS chemical biology (19.08.2011)
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Journal Article
Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay
Storaska, Andrew J., Mei, Jian P., Wu, Meng, Li, Min, Wade, Susan M., Blazer, Levi L., Sjögren, Benita, Hopkins, Corey R., Lindsley, Craig W., Lin, Zhihong, Babcock, Joseph J., McManus, Owen B., Neubig, Richard R.
Published in Cellular signalling (01.12.2013)
Published in Cellular signalling (01.12.2013)
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Journal Article
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator
Mattmann, Margrith E., Yu, Haibo, Lin, Zhihong, Xu, Kaiping, Huang, Xiaofang, Long, Shunyou, Wu, Meng, McManus, Owen B., Engers, Darren W., Le, Uyen M., Li, Min, Lindsley, Craig W., Hopkins, Corey R.
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
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