Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Cavazzuti, Antonio, Paglietti, Giuseppe, Hunter, William N, Gamarro, Francisco, Piras, Sandra, Loriga, Mario, Allecca, Sergio, Corona, Paola, McLuskey, Karen, Tulloch, Lindsay, Gibellini, Federica, Ferrari, Stefania, Costi, Maria Paola
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
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Journal Article
Ranking Metabolite Sets by Their Activity Levels
McLuskey, Karen, Wandy, Joe, Vincent, Isabel, van der Hooft, Justin J J, Rogers, Simon, Burgess, Karl, Daly, Rónán
Published in Metabolites (11.02.2021)
Published in Metabolites (11.02.2021)
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Journal Article
The Crystal Structure of the Periplasmic Domain of the Type II Secretion System Protein EpsM From Vibrio cholerae: The Simplest Version of the Ferredoxin Fold
Abendroth, Jan, Rice, Adrian E, McLuskey, Karen, Bagdasarian, Michael, Hol, Wim G.J
Published in Journal of molecular biology (30.04.2004)
Published in Journal of molecular biology (30.04.2004)
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Journal Article
Structure and Reactivity of Hydroxypropylphosphonic Acid Epoxidase in Fosfomycin Biosynthesis by a Cation- and Flavin-Dependent Mechanism
McLuskey, Karen, Cameron, Scott, Hammerschmidt, Friedrich, Hunter, William N., Davies, David R.
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2005)
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Journal Article
How photosynthetic bacteria harvest solar energy
Cogdell, R J, Isaacs, N W, Howard, T D, McLuskey, K, Fraser, N J, Prince, S M
Published in Journal of bacteriology (01.07.1999)
Published in Journal of bacteriology (01.07.1999)
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Journal Article
Insight into the Role of Escherichia coli MobB in Molybdenum Cofactor Biosynthesis Based on the High Resolution Crystal Structure
McLuskey, Karen, Harrison, Jennifer A, Schuttelkopf, Alexander W, Boxer, David H, Hunter, William N
Published in The Journal of biological chemistry (27.06.2003)
Published in The Journal of biological chemistry (27.06.2003)
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Journal Article
TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania
Myburgh, Elmarie, Geoghegan, Vincent, Alves-Ferreira, Eliza VC, Nievas, Y Romina, Grewal, Jaspreet S, Brown, Elaine, McLuskey, Karen, Mottram, Jeremy C
Published in EMBO reports (12.03.2024)
Published in EMBO reports (12.03.2024)
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Journal Article
Crystal Structure of Leishmania major Oligopeptidase B Gives Insight into the Enzymatic Properties of a Trypanosomatid Virulence Factor
McLuskey, Karen, Paterson, Neil G., Bland, Nicholas D., Isaacs, Neil W., Mottram, Jeremy C.
Published in The Journal of biological chemistry (10.12.2010)
Published in The Journal of biological chemistry (10.12.2010)
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Journal Article
Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome
McLuskey, Karen, Grewal, Jaspreet S., Das, Debanu, Godzik, Adam, Lesley, Scott A., Deacon, Ashley M., Coombs, Graham H., Elsliger, Marc-André, Wilson, Ian A., Mottram, Jeremy C.
Published in The Journal of biological chemistry (29.04.2016)
Published in The Journal of biological chemistry (29.04.2016)
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Journal Article
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast
Grewal, Jaspreet S., McLuskey, Karen, Das, Debanu, Myburgh, Elmarie, Wilkes, Jonathan, Brown, Elaine, Lemgruber, Leandro, Gould, Matthew K., Burchmore, Richard J., Coombs, Graham H., Schnaufer, Achim, Mottram, Jeremy C.
Published in The Journal of biological chemistry (29.04.2016)
Published in The Journal of biological chemistry (29.04.2016)
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Journal Article
Oligopeptidase B deficient mutants of Leishmania major
Munday, Jane C., McLuskey, Karen, Brown, Elaine, Coombs, Graham H., Mottram, Jeremy C.
Published in Molecular and biochemical parasitology (01.01.2011)
Published in Molecular and biochemical parasitology (01.01.2011)
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Journal Article
Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2
Machado, Maurício F. M., Marcondes, Marcelo F., Juliano, Maria A., McLuskey, Karen, Mottram, Jeremy C., Moss, Catherine X., Juliano, Luiz, Oliveira, Vitor
Published in The FEBS journal (01.06.2013)
Published in The FEBS journal (01.06.2013)
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Journal Article
Crystal structures of all-alpha type membrane proteins
McLuskey, Karen, Roszak, Aleksander W, Zhu, Yanshi, Isaacs, Neil W
Published in European biophysics journal (01.04.2010)
Published in European biophysics journal (01.04.2010)
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Journal Article
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
Dawson, Alice, Gibellini, Federica, Sienkiewicz, Natasha, Tulloch, Lindsay B., Fyfe, Paul K., McLuskey, Karen, Fairlamb, Alan H., Hunter, William N.
Published in Molecular microbiology (01.09.2006)
Published in Molecular microbiology (01.09.2006)
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Journal Article
High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins
Gabrielsen, Mads, Kroner, Frank, Black, Isobel, Isaacs, Neil W., Roe, Andrew J., McLuskey, Karen
Published in Molecular membrane biology (01.10.2011)
Published in Molecular membrane biology (01.10.2011)
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Journal Article
High-Throughput Methods for the Detection of Protein Overexpression Using Fluorescence Markers
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Book Chapter
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