TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype
Sallman, David A., McLemore, Amy F., Aldrich, Amy L., Komrokji, Rami S., McGraw, Kathy L., Dhawan, Abhishek, Geyer, Susan, Hou, Hsin-An, Eksioglu, Erika A., Sullivan, Amy, Warren, Sarah, MacBeth, Kyle J., Meggendorfer, Manja, Haferlach, Torsten, Boettcher, Steffen, Ebert, Benjamin L., Al Ali, Najla H., Lancet, Jeffrey E., Cleveland, John L., Padron, Eric, List, Alan F.
Published in Blood (10.12.2020)
Published in Blood (10.12.2020)
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Journal Article
Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes
Ward, Grace A, Dalton, 3rd, Robert P, Meyer, Benjamin S, McLemore, Amy F, Aldrich, Amy L, Lam, Nghi B, Onimus, Alexis H, Vincelette, Nicole D, Trinh, Thu Le, Chen, Xianghong, Calescibetta, Alexandra R, Christiansen, Sean M, Hou, Hsin-An, Johnson, Joseph O, Wright, Kenneth L, Padron, Eric, Eksioglu, Erika A, List, Alan F
Published in International journal of molecular sciences (15.02.2023)
Published in International journal of molecular sciences (15.02.2023)
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Journal Article
Dual pyroptotic biomarkers predict erythroid response in lower-risk non-del(5q) myelodysplastic syndromes treated with lenalidomide and recombinant erythropoietin
Wang, Chen, McGraw, Kathy L, McLemore, Amy F, Komrokji, Rami, Basiorka, Ashley A, Al Ali, Najla, Lancet, Jeffrey E, Padron, Eric, Kosmider, Olivier, Fontenay, Michaela, Fenaux, Pierre, List, Alan F, Sallman, David A
Published in Haematologica (Roma) (01.03.2022)
Published in Haematologica (Roma) (01.03.2022)
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Journal Article
Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes
McLemore, Amy F., Hou, Hsin-An, Meyer, Benjamin S., Lam, Nghi B., Ward, Grace A., Aldrich, Amy L., Rodrigues, Matthew A., Vedder, Alexis, Zhang, Ling, Padron, Eric, Vincelette, Nicole D., Sallman, David A., Abdel-Wahab, Omar, List, Alan F., McGraw, Kathy L.
Published in JCI insight (08.08.2022)
Published in JCI insight (08.08.2022)
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Journal Article
Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes
Ward, Grace A., McGraw, Kathy L., Abbas-Aghababazadeh, Farnoosh, Meyer, Benjamin S., McLemore, Amy F., Vincelette, Nicole D., Lam, Nghi B., Aldrich, Amy L., Al Ali, Najla H., Padron, Eric, Pinilla-Ibarz, Javier, Masala, Erico, Santini, Valeria, Kosmider, Olivier, Fontenay, Michaela, Fenaux, Pierre, Johnson, Joseph, Fridley, Brooke L., List, Alan F.
Published in Blood advances (27.04.2021)
Published in Blood advances (27.04.2021)
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Pyroptosis Markers in Human Primary Specimens: Quantification of Intracellular ASC Specks by Imaging Flow Cytometry and Extracellular Oxidized Mitochondrial by ELISA
McLemore, Amy F, Lage, Silvia L, Dominical, Venina M, Rodrigues, Matthew A, McGraw, Kathy L
Published in Methods in molecular biology (Clifton, N.J.) (2023)
Published in Methods in molecular biology (Clifton, N.J.) (2023)
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Journal Article
RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
Ben-Crentsil, Nana Adjoa, Mohammed Ismail, Wazim, Balasis, Maria E, Newman, Hannah, Quintana, Ariel, Binder, Moritz, Kruer, Traci, Neupane, Surendra, Ferrall-Fairbanks, Meghan C, Fernandez, Jenna, Lasho, Terra L, Finke, Christy M, Ibrahim, Mohammed L, McGraw, Kathy L, Wysota, Michael, Aldrich, Amy L, Ryder, Christopher B, Letson, Christopher T, Traina, Joshua, McLemore, Amy F, Droin, Nathalie, Shastri, Aditi, Yun, Seongseok, Solary, Eric, Sallman, David A, Beg, Amer A, Ma, Li, Gaspar-Maia, Alexandre, Patnaik, Mrinal M, Padron, Eric
Published in Cancer discovery (27.08.2024)
Published in Cancer discovery (27.08.2024)
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Journal Article
Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study
Basiorka, Ashley A, McGraw, Kathy L, Abbas-Aghababazadeh, Farnoosh, McLemore, Amy F, Vincelette, Nicole D, Ward, Grace A, Eksioglu, Erika A, Sallman, David A, Ali, Najla Al, Padron, Eric, Pinilla-Ibarz, Javier, Komrokji, Rami, Masala, Erico, Santini, Valeria, Kosmider, Olivier, Fontenay, Michaela, Fenaux, Pierre, Sokol, Lubomir, Wei, Sheng, Fridley, Brooke, List, Alan F
Published in The Lancet. Haematology (01.09.2018)
Published in The Lancet. Haematology (01.09.2018)
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Journal Article
XPO1 Overexpression Is a Mechanism of Resistance to Eprenetapopt and 5-Azacitidine Therapy That Can be Therapeutically Exploited for the Treatment of TP53 Mutated Myeloid Malignancies
Kruer, Traci L., Quintana, Ariel, Ferrall-Fairbanks, Meghan, Zhang, Ling, Newman, Hannah, McLemore, Amy F, Yang, Qin, Bencrentsil, Nana, Komrokji, Rami S., Chaudhry, Sana, Totiger, Tulasigeri M, Figueroa, Maria Ken E., Taylor, Justin, Sallman, David A., Padron, Eric
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes
Ward, Grace A, McGraw, Kathy, McLemore, Amy F, Lam, Nghi B, Hou, Hsin-An, Meyer, Benjamin S., List, Alan F.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Dysregulation of Splicing Patterns in MDS Induced By the S100A9/Fto Axis
Eksioglu, Erika Adriana, Cen, Ling, Chen, Xianghong, Cheng, Pingyan, Wright, Kenneth, Trinh, Thu Le, Gilvary, Danielle, Kandell, Wendy, Liu, Jinhong, Chen, Yin-Kai, McLemore, Amy F, Calescibetta, Alexandra, Cleveland, John, List, Alan F., Wei, Sheng
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Long Term Follow-up and Combined Phase 2 Results of Eprenetapopt (APR-246) and Azacitidine (AZA) in Patients with TP53 mutant Myelodysplastic Syndromes (MDS) and Oligoblastic Acute Myeloid Leukemia (AML)
Sallman, David A., Komrokji, Rami S., DeZern, Amy E., Sebert, Marie, Garcia-Manero, Guillermo, Rahmé, Ramy, Steensma, David P., Lehmann che, Jacqueline, Roboz, Gail J., Madelaine, Isabelle, Sekeres, Mikkael A., Peterlin, Pierre, Sweet, Kendra, Beyne Rauzy, Odile, Kuykendall, Andrew T., Recher, Christian, McLemore, Amy F, Stamatoullas, Aspasia, Zhang, Ling, Willems, Lise, Mo, Qianxing, Raffoux, Emmanuel, Nardelli, Lisa, Berthon, Celine, Al Ali, Najla, Quesnel, Bruno, Padron, Eric, Korbel, Greg, Attar, Eyal C., Kantarjian, Hagop, List, Alan F., Ades, Lionel, Lancet, Jeffrey E., Fenaux, Pierre, Cluzeau, Thomas
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes
Ward, Grace A, McGraw, Kathy L, McLemore, Amy F, Abbas-Aghababazadeh, Farnoosh, Hou, Hsin-An, Trinh, Thu Le, Vincelette, Nicole D., Meyer, Benjamin S., Onimus, Alexis H, Calescibetta, Alexandra, Eksioglu, Erika A, Wei, Sheng, List, Alan F.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Genomic-DNA Exposed By Somatic Gene Mutations Engages the cGAS/STING Axis to License the NLRP3 Inflammasome in Myelodysplastic Syndromes
McLemore, Amy F, McGraw, Kathy L, Hou, Hsin-An, Ward, Grace A, Onimus, Alexis H, Vincelette, Nicole D., Rodrigues, Matthew A., Chaudhary, Neelkamal, Zhang, Ling, Meyer, Benjamin S., Eksioglu, Erika A, Wei, Sheng, List, Alan F.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Phase 2 Results of APR-246 and Azacitidine (AZA) in Patients with TP53 mutant Myelodysplastic Syndromes (MDS) and Oligoblastic Acute Myeloid Leukemia (AML)
Sallman, David A, DeZern, Amy E., Garcia-Manero, Guillermo, Steensma, David P., Roboz, Gail J., Sekeres, Mikkael A., Cluzeau, Thomas, Sweet, Kendra L., McLemore, Amy F, McGraw, Kathy, Puskas, John, Zhang, Ling, Yao, Jiqiang, Mo, Qianxing, Nardelli, Lisa, Al Ali, Najla, Padron, Eric, Korbel, Greg, Attar, Eyal C., Kantarjian, Hagop M., Lancet, Jeffrey E., Fenaux, Pierre, List, Alan F., Komrokji, Rami S.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Phase 1b/2 Combination Study of APR-246 and Azacitidine (AZA) in Patients with TP53 mutant Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Sallman, David A, DeZern, Amy E., Steensma, David P., Sweet, Kendra L., Cluzeau, Thomas, Sekeres, Mikkael A., Garcia-Manero, Guillermo, Roboz, Gail J., McLemore, Amy F, McGraw, Kathy L, Puskas, John, Zhang, Ling, Bhagat, Chirag K, Yao, Jiqiang, Al Ali, Najla, Padron, Eric, Tell, Roger, Lancet, Jeffrey E., Fenaux, Pierre, List, Alan F., Komrokji, Rami S.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article