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Published in Cancer research (Chicago, Ill.) (15.04.2001)
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Utility of siRNA against Keap1 as a Strategy to Stimulate a Cancer Chemopreventive Phenotype
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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
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Transcription Factor Nrf2 Is Essential for Induction of NAD(P)H:Quinone Oxidoreductase 1, Glutathione S-Transferases, and Glutamate Cysteine Ligase by Broccoli Seeds and Isothiocyanates
McWalter, Gail K., Higgins, Larry G., McLellan, Lesley I., Henderson, Colin J., Hayes, John D., Song, Lijiang, Thornalley, Paul J., Itoh, Ken, Yamamoto, Masayuki
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The Modifier Subunit of Drosophila Glutamate-Cysteine Ligase Regulates Catalytic Activity by Covalent and Noncovalent Interactions and Influences Glutathione Homeostasis in Vivo
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Published in The Journal of biological chemistry (21.11.2003)
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Reduction of Gstm1 Expression in the Stroke-Prone Spontaneously Hypertension Rat Contributes to Increased Oxidative Stress
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Published in Hypertension (Dallas, Tex. 1979) (01.04.2005)
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Drosophila melanogaster Glutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form
Fraser, Jennifer A, Saunders, Robert D C, McLellan, Lesley I
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Antioxidant and cytoprotective responses to redox stress
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Published in Biochemical Society Symposia (01.01.2004)
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Regulation of rat glutamate-cysteine ligase (γ-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B1-induced preneoplasia
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Published in Carcinogenesis (New York) (01.10.2000)
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Uptake and distribution of N-acetylcysteine in mice: tissue-specific effects on glutathione concentrations
McLellan, L I, Lewis, A D, Hall, D J, Ansell, J D, Wolf, C R
Published in Carcinogenesis (New York) (01.09.1995)
Published in Carcinogenesis (New York) (01.09.1995)
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Overexpression of the regulatory subunit of γ-glutamylcysteine synthetase in HeLa cells increases γ-glutamylcysteine synthetase activity and confers drug resistance
TIPNIS, Sarah R., BLAKE, David G., SHEPHERD, A.Graeme, McLELLAN, Lesley I.
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Published in Biochemical journal (01.02.1999)
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Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
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Published in American Journal of Physiology: Cell Physiology (01.01.2006)
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