Substituted 3-Imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3
Engler, Thomas A, Henry, James R, Malhotra, Sushant, Cunningham, Brian, Furness, Kelly, Brozinick, Joseph, Burkholder, Timothy P, Clay, Michael P, Clayton, Joshua, Diefenbacher, Clive, Hawkins, Eric, Iversen, Philip W, Li, Yihong, Lindstrom, Terry D, Marquart, Angela L, McLean, Johnathan, Mendel, David, Misener, Elizabeth, Briere, Daniel, O'Toole, John C, Porter, Warren J, Queener, Steven, Reel, Jon K, Owens, Rebecca A, Brier, Richard A, Eessalu, Thomas E, Wagner, Jill R, Campbell, Robert M, Vaughn, Renee
Published in Journal of medicinal chemistry (29.07.2004)
Published in Journal of medicinal chemistry (29.07.2004)
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Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model
Burkholder, Timothy P., Clayton, Joshua R., Rempala, Mark E., Henry, James R., Knobeloch, John M., Mendel, David, McLean, Johnathan A., Hao, Yan, Barda, David A., Considine, Eileen L., Uhlik, Mark T., Chen, Yuefeng, Ma, Liandong, Bloem, Laura J., Akunda, Jacqueline K., McCann, Denis J., Sanchez-Felix, Manuel, Clawson, David K., Lahn, Michael M., Starling, James J.
Published in Investigational new drugs (01.06.2012)
Published in Investigational new drugs (01.06.2012)
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Erratum to: Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model
Burkholder, Timothy P., Clayton, Joshua R., Rempala, Mark E., Henry, James R., Knobeloch, John M., Mendel, David, McLean, Johnathan A., Hao, Yan, Barda, David A., Considine, Eileen L., Uhlik, Mark T., Chen, Yuefeng, Ma, Liandong, Bloem, Laura J., Akunda, Jacqueline K., McCann, Denis J., Sanchez-Felix, Manuel, Clawson, David K., Lahn, Michael M., Starling, James J.
Published in Investigational new drugs (01.06.2012)
Published in Investigational new drugs (01.06.2012)
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The development of potent and selective bisarylmaleimide GSK3 inhibitors
Engler, Thomas A., Malhotra, Sushant, Burkholder, Timothy P., Henry, James R., Mendel, David, Porter, Warren J., Furness, Kelly, Diefenbacher, Clive, Marquart, Angela, Reel, Jon K., Li, Yihong, Clayton, Joshua, Cunningham, Brian, McLean, Johnathan, O’Toole, John C., Brozinick, Joseph, Hawkins, Eric, Misener, Elizabeth, Briere, Daniel, Brier, Richard A., Wagner, Jill R., Campbell, Robert M., Anderson, Bryan D., Vaughn, Renee, Bennett, Donald B., Meier, Timothy I., Cook, James A.
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Abstract 3231: Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996
Zhao, Gaiying, McMillen, William T., Cai, Shufen, Zhao, Baohui, Whitesell, Matthew, Wu, Wenjuan, Huss, Karen, Anderson, Bryan, Yuan, Xiu-Juan, Jaken, Susan, Kindler, Lisa, Flack, Robert S., McCann, Denis, Mathes, Brian, Dropsey, Andrew J., Walgren, Jennie, Yuen, Eunice, Manro, Jason, Gong, Xueqian, Cortez, Guillermo, McLean, Johnathan, Rodriguez, Michael J., Tiu, Ramon V., Bhagwat, Shripad V., Joseph, Sajan
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Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Year of Publication 31.01.2024
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Year of Publication 07.07.2023
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포스포이노시티드 3-키나제 (PI3K) 조정과 연관된 질환의 치료를 위한 PI3K의 알로스테릭 크로메논 억제제
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Year of Publication 09.12.2022
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ERK [23-c]-4- THIENO[23-C]PYRROL-4-ONE DERIVATIVES AS ERK INHIBITORS
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Year of Publication 13.07.2021
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Year of Publication 30.04.2024
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Year of Publication 27.04.2023
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Year of Publication 21.03.2024
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Year of Publication 23.01.2024
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Year of Publication 23.01.2024
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ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF CANCER
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Year of Publication 07.12.2023
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Year of Publication 07.12.2023
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THIENO[2,3-C]PYRROL-4-ONE DERIVATIVES AS ERK INHIBITORS
RODRIGUEZ, MICHAEL JOHN, CORTEZ, GUILLERMO S, JOSEPH, SAJAN, ZHAO, GAIYING, MCMILLEN, WILLIAM T, MCLEAN, JOHNATHAN ALEXANDER
Year of Publication 31.01.2020
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Year of Publication 31.01.2020
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