Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
Rocha, Emily M, Smith, Gaynor A, Park, Eric, Cao, Hongmei, Brown, Eilish, Hayes, Melissa A, Beagan, Jonathan, McLean, Jesse R, Izen, Sarah C, Perez-Torres, Eduardo, Hallett, Penelope J, Isacson, Ole
Published in Neurobiology of disease (01.10.2015)
Published in Neurobiology of disease (01.10.2015)
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Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection
McLean, Jesse R., Smith, Gaynor A., Rocha, Emily M., Hayes, Melissa A., Beagan, Jonathan A., Hallett, Penelope J., Isacson, Ole
Published in Neuroscience letters (25.07.2014)
Published in Neuroscience letters (25.07.2014)
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A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C)
Smith, Gaynor A, Rocha, Emily M, Rooney, Thomas, Barneoud, Pascal, McLean, Jesse R, Beagan, Jonathan, Osborn, Teresia, Coimbra, Madeleine, Luo, Yongyi, Hallett, Penelope J, Isacson, Ole
Published in PloS one (27.03.2015)
Published in PloS one (27.03.2015)
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Jump from Pre-mutation to Pathologic Expansion in C9orf72
Xi, Zhengrui, van Blitterswijk, Marka, Zhang, Ming, McGoldrick, Philip, McLean, Jesse R., Yunusova, Yana, Knock, Erin, Moreno, Danielle, Sato, Christine, McKeever, Paul M., Schneider, Raphael, Keith, Julia, Petrescu, Nicolae, Fraser, Paul, Tartaglia, Maria Carmela, Baker, Matthew C., Graff-Radford, Neill R., Boylan, Kevin B., Dickson, Dennis W., Mackenzie, Ian R., Rademakers, Rosa, Robertson, Janice, Zinman, Lorne, Rogaeva, Ekaterina
Published in American journal of human genetics (04.06.2015)
Published in American journal of human genetics (04.06.2015)
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Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis
Xiao, Shangxi, MacNair, Laura, McGoldrick, Philip, McKeever, Paul M., McLean, Jesse R., Zhang, Ming, Keith, Julia, Zinman, Lorne, Rogaeva, Ekaterina, Robertson, Janice
Published in Annals of neurology (01.10.2015)
Published in Annals of neurology (01.10.2015)
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Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice
Rocha, Emily M, Smith, Gaynor A, Park, Eric, Cao, Hongmei, Graham, Anne-Renee, Brown, Eilish, McLean, Jesse R, Hayes, Melissa A, Beagan, Jonathan, Izen, Sarah C, Perez-Torres, Eduardo, Hallett, Penelope J, Isacson, Ole
Published in Antioxidants & redox signaling (20.08.2015)
Published in Antioxidants & redox signaling (20.08.2015)
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Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease
Cooper, Oliver, Seo, Hyemyung, Andrabi, Shaida, Guardia-Laguarta, Cristina, Graziotto, John, Sundberg, Maria, McLean, Jesse R, Carrillo-Reid, Luis, Xie, Zhong, Osborn, Teresia, Hargus, Gunnar, Deleidi, Michela, Lawson, Tristan, Bogetofte, Helle, Perez-Torres, Eduardo, Clark, Lorraine, Moskowitz, Carol, Mazzulli, Joseph, Chen, Li, Volpicelli-Daley, Laura, Romero, Norma, Jiang, Houbo, Uitti, Ryan J, Huang, Zhigao, Opala, Grzegorz, Scarffe, Leslie A, Dawson, Valina L, Klein, Christine, Feng, Jian, Ross, Owen A, Trojanowski, John Q, Lee, Virginia M-Y, Marder, Karen, Surmeier, D James, Wszolek, Zbigniew K, Przedborski, Serge, Krainc, Dimitri, Dawson, Ted M, Isacson, Ole
Published in Science translational medicine (04.07.2012)
Published in Science translational medicine (04.07.2012)
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Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease
Smith, Gaynor A, Rocha, Emily M, McLean, Jesse R, Hayes, Melissa A, Izen, Sarah C, Isacson, Ole, Hallett, Penelope J
Published in Human molecular genetics (01.09.2014)
Published in Human molecular genetics (01.09.2014)
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Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression
McLean, Jesse R., Hallett, Penelope J., Cooper, Oliver, Stanley, Michael, Isacson, Ole
Published in Molecular and cellular neuroscience (01.02.2012)
Published in Molecular and cellular neuroscience (01.02.2012)
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A two‐hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25‐interacting protein, SIP30
Gentil, Benoit J., McLean, Jesse R., Xiao, Shangxi, Zhao, Beibei, Durham, Heather D., Robertson, Janice
Published in Journal of neurochemistry (01.12.2014)
Published in Journal of neurochemistry (01.12.2014)
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An Aggregate-Inducing Peripherin Isoform Generated through Intron Retention Is Upregulated in Amyotrophic Lateral Sclerosis and Associated with Disease Pathology
Xiao, Shangxi, Tjostheim, Sonja, Sanelli, Teresa, McLean, Jesse R, Horne, Patrick, Fan, Yuxin, Ravits, John, Strong, Michael J, Robertson, Janice
Published in The Journal of neuroscience (20.02.2008)
Published in The Journal of neuroscience (20.02.2008)
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ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress
McLean, Jesse R., Smith, Gaynor A., Rocha, Emily M., Osborn, Teresia M., Dib, Samar, Hayes, Melissa A., Beagan, Jonathan A., Brown, Tana B., Lawson, Tristan F.S., Hallett, Penelope J., Robertson, Janice, Isacson, Ole
Published in Experimental neurology (01.11.2014)
Published in Experimental neurology (01.11.2014)
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Isoform‐specific antibodies reveal distinct subcellular localizations of C 9orf72 in amyotrophic lateral sclerosis
Xiao, Shangxi, MacNair, Laura, McGoldrick, Philip, McKeever, Paul M., McLean, Jesse R., Zhang, Ming, Keith, Julia, Zinman, Lorne, Rogaeva, Ekaterina, Robertson, Janice
Published in Annals of neurology (01.10.2015)
Published in Annals of neurology (01.10.2015)
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A Nurr1 Agonist Causes Neuroprotection in a Parkinson's Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C): e0121072
Smith, Gaynor A, Rocha, Emily M, Rooney, Thomas, Barneoud, Pascal, McLean, Jesse R, Beagan, Jonathan, Osborn, Teresia, Coimbra, Madeleine, Luo, Yongyi, Hallett, Penelope J
Published in PloS one (01.03.2015)
Published in PloS one (01.03.2015)
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