MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans
Atack, J R, Wafford, K A, Street, L J, Dawson, G R, Tye, S, Van Laere, K, Bormans, G, Sanabria-Bohórquez, S M, De Lepeleire, I, de Hoon, J N, Van Hecken, A, Burns, H D, McKernan, R M, Murphy, M G, Hargreaves, R J
Published in Journal of psychopharmacology (Oxford) (01.03.2011)
Published in Journal of psychopharmacology (Oxford) (01.03.2011)
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Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist
Atack, J R, Hallett, D J, Tye, S, Wafford, K A, Ryan, C, Sanabria-Bohórquez, S M, Eng, Wai-Si, Gibson, R E, Burns, H D, Dawson, G R, Carling, R W, Street, L J, Pike, A, De Lepeleire, I, Van Laere, K, Bormans, G, de Hoon, J N, Van Hecken, A, McKernan, R M, Murphy, M G, Hargreaves, R J
Published in Journal of psychopharmacology (Oxford) (01.03.2011)
Published in Journal of psychopharmacology (Oxford) (01.03.2011)
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Age-related changes in GABA A receptor subunit composition and function in rat auditory system
Caspary, D.M, Holder, T.M, Hughes, L.F, Milbrandt, J.C, McKernan, R.M, Naritoku, D.K
Published in Neuroscience (01.01.1999)
Published in Neuroscience (01.01.1999)
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Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor
Dawson, G R, Wafford, K A, Smith, A, Marshall, G R, Bayley, P J, Schaeffer, J M, Meinke, P T, McKernan, R M
Published in The Journal of pharmacology and experimental therapeutics (01.12.2000)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.2000)
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Model of subunit composition of gamma-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their alpha and gamma/delta subunits
QUIRK, K, GILLARD, N. P, RAGAN, C. I, WHITING, P. J, MCKERNAN, R. M
Published in The Journal of biological chemistry (10.06.1994)
Published in The Journal of biological chemistry (10.06.1994)
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Stable Expression of Mammalian type A γ-Aminobutyric Acid Receptors in Mouse Cells: Demonstration of Functional Assembly of Benzodiazepine- Responsive Sites
Hadingham, Karen L., Harkness, Patricia C., McKernan, Ruth M., Quirk, Kathleen, Le Bourdelles, Beatrice, Horne, Anthony L., Kemp, John A., Barnard, Eric A., Ragan, C. Ian, Whiting, Paul J.
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.1992)
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.1992)
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gamma-Aminobutyric acid type A receptors in the rat brain can contain both gamma 2 and gamma 3 subunits, but gamma 1 does not exist in combination with another gamma subunit
Quirk, K, Gillard, N P, Ragan, C I, Whiting, P J, McKernan, R M
Published in Molecular pharmacology (01.06.1994)
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Published in Molecular pharmacology (01.06.1994)
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Localization of 5-HT3 receptors in the rat spinal cord: immunohistochemistry and in situ hybridization
Kia, H K, Miquel, M C, McKernan, R M, Laporte, A M, Lombard, M C, Bourgoin, S, Hamon, M, Vergé, D
Published in Neuroreport (26.01.1995)
Published in Neuroreport (26.01.1995)
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Generation and characterisation of stable cell lines expressing recombinant human N-methyl-D-aspartate receptor subtypes
Grimwood, S, Le Bourdellès, B, Atack, J R, Barton, C, Cockett, W, Cook, S M, Gilbert, E, Hutson, P H, McKernan, R M, Myers, J, Ragan, C I, Wingrove, P B, Whiting, P J
Published in Journal of neurochemistry (01.06.1996)
Published in Journal of neurochemistry (01.06.1996)
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Stoichiometry of a Ligand-gated Ion Channel Determined by Fluorescence Energy Transfer
Farrar, S J, Whiting, P J, Bonnert, T P, McKernan, R M
Published in The Journal of biological chemistry (09.04.1999)
Published in The Journal of biological chemistry (09.04.1999)
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Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice
Sur, C, Wafford, K A, Reynolds, D S, Hadingham, K L, Bromidge, F, Macaulay, A, Collinson, N, O'Meara, G, Howell, O, Newman, R, Myers, J, Atack, J R, Dawson, G R, McKernan, R M, Whiting, P J, Rosahl, T W
Published in The Journal of neuroscience (15.05.2001)
Published in The Journal of neuroscience (15.05.2001)
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θ , a Novel γ -Aminobutyric Acid Type A Receptor Subunit
Bonnert, Timothy P., McKernan, Ruth M., Farrar, Sophie, le Bourdellès, Béatrice, Heavens, Robert P., Smith, David W., Hewson, Louise, Rigby, Michael R., Dalip J. S. Sirinathsinghji, Brown, Nicola, Wafford, Keith A., Whiting, Paul J.
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.1999)
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Molecular and Functional Diversity of the Expanding GABA-A Receptor Gene Family
WHITING, PAUL J., BONNERT, TIMOTHY P., MCKERNAN, RUTH M., FARRAR, SOPHIE, BOURDELLES, BEATRICE LE, HEAVENS, ROBERT P., SMITH, DAVID W., HEWSON, LOUISE, RIGBY, MICHAEL R., SIRINATHSINGHJI, DALIP J. S., THOMPSON, SALLY A., WAFFORD, KEITH A.
Published in Annals of the New York Academy of Sciences (01.04.1999)
Published in Annals of the New York Academy of Sciences (01.04.1999)
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Evidence that porcine native 5-HT3 receptors do not contain nicotinic acetylcholine receptor subunits
FLETCHER, S, LINDSTROM, J. M, MCKERNAN, R. M, BARNES, N. M
Published in Neuropharmacology (01.01.1998)
Published in Neuropharmacology (01.01.1998)
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