Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs
Satoh, Takumi, McKercher, Scott R, Lipton, Stuart A
Published in Free radical biology & medicine (01.12.2013)
Published in Free radical biology & medicine (01.12.2013)
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Aberrant protein S -nitrosylation contributes to the pathophysiology of neurodegenerative diseases
Nakamura, Tomohiro, Prikhodko, Olga A, Pirie, Elaine, Nagar, Saumya, Akhtar, Mohd Waseem, Oh, Chang-Ki, McKercher, Scott R, Ambasudhan, Rajesh, Okamoto, Shu-ichi, Lipton, Stuart A
Published in Neurobiology of disease (01.12.2015)
Published in Neurobiology of disease (01.12.2015)
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Journal Article
S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide
Qu, Jing, Nakamura, Tomohiro, Cao, Gang, Holland, Emily A, McKercher, Scott R, Lipton, Stuart A
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2011)
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Journal Article
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
Akhtar, Mohd Waseem, Sanz-Blasco, Sara, Dolatabadi, Nima, Parker, James, Chon, Kevin, Lee, Michelle S., Soussou, Walid, McKercher, Scott R., Ambasudhan, Rajesh, Nakamura, Tomohiro, Lipton, Stuart A.
Published in Nature communications (08.01.2016)
Published in Nature communications (08.01.2016)
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Wild-Type Microglia Extend Survival in PU.1 Knockout Mice with Familial Amyotrophic Lateral Sclerosis
Beers, David R., Henkel, Jenny S., Xiao, Qin, Zhao, Weihua, Wang, Jinghong, Yen, Albert A., Siklos, Laszlo, McKercher, Scott R., Appel, Stanley H.
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2006)
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Journal Article
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
Tu, Shichun, Akhtar, Mohd Waseem, Escorihuela, Rosa Maria, Amador-Arjona, Alejandro, Swarup, Vivek, Parker, James, Zaremba, Jeffrey D., Holland, Timothy, Bansal, Neha, Holohan, Daniel R., Lopez, Kevin, Ryan, Scott D., Chan, Shing Fai, Yan, Li, Zhang, Xiaofei, Huang, Xiayu, Sultan, Abdullah, McKercher, Scott R., Ambasudhan, Rajesh, Xu, Huaxi, Wang, Yuqiang, Geschwind, Daniel H., Roberts, Amanda J., Terskikh, Alexey V., Rissman, Robert A., Masliah, Eliezer, Lipton, Stuart A., Nakanishi, Nobuki
Published in Nature communications (14.11.2017)
Published in Nature communications (14.11.2017)
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Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models
Lipton, Stuart A, Rezaie, Tayebeh, Nutter, Anthony, Lopez, Kevin M, Parker, James, Kosaka, Kunio, Satoh, Takumi, McKercher, Scott R, Masliah, Eliezer, Nakanishi, Nobuki
Published in Cell death & disease (01.12.2016)
Published in Cell death & disease (01.12.2016)
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Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells
Zhu, Saiyong, Ambasudhan, Rajesh, Sun, Woong, Kim, Hyun Jung, Talantova, Maria, Wang, Xiaojing, Zhang, Mingliang, Zhang, Yu, Laurent, Timothy, Parker, James, Kim, Han-Seop, Zaremba, Jeffrey D, Saleem, Sofiyan, Sanz-Blasco, Sara, Masliah, Eliezer, McKercher, Scott R, Cho, Yee Sook, Lipton, Stuart A, Kim, Janghwan, Ding, Sheng
Published in Cell research (01.01.2014)
Published in Cell research (01.01.2014)
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Journal Article
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo
Li, Hao, Radford, Jonathan C, Ragusa, Michael J, Shea, Katherine L, McKercher, Scott R, Zaremba, Jeffrey D, Soussou, Walid, Nie, Zhiguo, Kang, Yeon-Joo, Nakanishi, Nobuki, Okamoto, Shu-ichi, Roberts, Amanda J, Schwarz, John J, Lipton, Stuart A
Published in Proceedings of the National Academy of Sciences - PNAS (08.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (08.07.2008)
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Journal Article
MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress
Nagar, Saumya, Noveral, Sarah M., Trudler, Dorit, Lopez, Kevin M., McKercher, Scott R., Han, Xuemei, Yates, John R., Piña-Crespo, Juan C., Nakanishi, Nobuki, Satoh, Takumi, Okamoto, Shu-ichi, Lipton, Stuart A.
Published in Proceedings of the National Academy of Sciences - PNAS (16.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (16.05.2017)
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Journal Article
Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration
Rezaie, Tayebeh, McKercher, Scott R, Kosaka, Kunio, Seki, Masaaki, Wheeler, Larry, Viswanath, Veena, Chun, Teresa, Joshi, Rabina, Valencia, Marcos, Sasaki, Shunsuke, Tozawa, Terumasa, Satoh, Takumi, Lipton, Stuart A
Published in Investigative ophthalmology & visual science (27.11.2012)
Published in Investigative ophthalmology & visual science (27.11.2012)
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Journal Article
S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke
SHI, Zhong-Qing, SUNICO, Carmen R, MCKERCHER, Scott R, JIANKUN CUI, FENG, Gen-Sheng, NAKAMURA, Tomohiro, LIPTON, Stuart A
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2013)
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Journal Article
NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model
Okamoto, Shu-ichi, Prikhodko, Olga, Pina-Crespo, Juan, Adame, Anthony, McKercher, Scott R., Brill, Laurence M., Nakanishi, Nobuki, Oh, Chang-ki, Nakamura, Tomohiro, Masliah, Eliezer, Lipton, Stuart A.
Published in Neurobiology of disease (01.07.2019)
Published in Neurobiology of disease (01.07.2019)
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Journal Article
S-Nitrosylation-Mediated Redox Transcriptional Switch Modulates Neurogenesis and Neuronal Cell Death
Okamoto, Shu-ichi, Nakamura, Tomohiro, Cieplak, Piotr, Chan, Shing Fai, Kalashnikova, Evgenia, Liao, Lujian, Saleem, Sofiyan, Han, Xuemei, Clemente, Arjay, Nutter, Anthony, Sances, Sam, Brechtel, Christopher, Haus, Daniel, Haun, Florian, Sanz-Blasco, Sara, Huang, Xiayu, Li, Hao, Zaremba, Jeffrey D., Cui, Jiankun, Gu, Zezong, Nikzad, Rana, Harrop, Anne, McKercher, Scott R., Godzik, Adam, Yates, John R., Lipton, Stuart A.
Published in Cell reports (Cambridge) (10.07.2014)
Published in Cell reports (Cambridge) (10.07.2014)
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Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
Takahashi, Hiroto, Xia, Peng, Cui, Jiankun, Talantova, Maria, Bodhinathan, Karthik, Li, Wenjun, Saleem, Sofiyan, Holland, Emily A., Tong, Gary, Piña-Crespo, Juan, Zhang, Dongxian, Nakanishi, Nobuki, Larrick, James W., McKercher, Scott R., Nakamura, Tomohiro, Wang, Yuqiang, Lipton, Stuart A.
Published in Scientific reports (19.10.2015)
Published in Scientific reports (19.10.2015)
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Journal Article
Dual neuroprotective pathways of a pro‐electrophilic compound via HSF‐1‐activated heat‐shock proteins and Nrf2‐activated phase 2 antioxidant response enzymes
Satoh, Takumi, Rezaie, Tayebeh, Seki, Masaaki, Sunico, Carmen R., Tabuchi, Takahito, Kitagawa, Tomomi, Yanagitai, Mika, Senzaki, Mutsumi, Kosegawa, Chihiro, Taira, Hideharu, McKercher, Scott R., Hoffman, Jennifer K., Roth, Gregory P., Lipton, Stuart A.
Published in Journal of neurochemistry (01.11.2011)
Published in Journal of neurochemistry (01.11.2011)
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Journal Article
MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model
Cho, Eun-Gyung, Zaremba, Jeffrey D, McKercher, Scott R, Talantova, Maria, Tu, Shichun, Masliah, Eliezer, Chan, Shing Fai, Nakanishi, Nobuki, Terskikh, Alexey, Lipton, Stuart A
Published in PloS one (25.08.2011)
Published in PloS one (25.08.2011)
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Journal Article
S-nitrosylation of Cdk5: Potential implications in amyloid-β-related neurotoxicity in Alzheimer disease
Qu, Jing, Nakamura, Tomohiro, Holland, Emily A., McKercher, Scott R., Lipton, Stuart A.
Published in Prion (01.09.2012)
Published in Prion (01.09.2012)
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Journal Article
Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential
Satoh, Takumi, Stalder, Romain, McKercher, Scott R., Williamson, Robert E., Roth, Gregory P., Lipton, Stuart A.
Published in ASN neuro (01.07.2015)
Published in ASN neuro (01.07.2015)
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