Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase
Kukolj, George, McGibbon, Graham A., McKercher, Ginette, Marquis, Martin, Lefèbvre, Sylvain, Thauvette, Louise, Gauthier, Jean, Goulet, Sylvie, Poupart, Marc-André, Beaulieu, Pierre L.
Published in The Journal of biological chemistry (25.11.2005)
Published in The Journal of biological chemistry (25.11.2005)
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Non-Nucleoside Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus NS5B Polymerase: Inhibition of Subgenomic Hepatitis C Virus RNA Replicons in Huh-7 Cells
Beaulieu, Pierre L, Bousquet, Yves, Gauthier, Jean, Gillard, James, Marquis, Martin, McKercher, Ginette, Pellerin, Charles, Valois, Serge, Kukolj, George
Published in Journal of medicinal chemistry (30.12.2004)
Published in Journal of medicinal chemistry (30.12.2004)
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A Simple Variable Number of Tandem Repeat-Based Genotyping Strategy for the Detection of Handling Errors and Validation of Sample Identity in Biobanks
Pellerin, Charles, McKercher, Ginette, Aprikian, Armen G, Saad, Fred, Lacombe, Louis, Carmel, Michel, Chevalier, Simone
Published in Biopreservation and biobanking (01.10.2016)
Published in Biopreservation and biobanking (01.10.2016)
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Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds
Beaulieu, Pierre L., Gillard, James, Bykowski, Darren, Brochu, Christian, Dansereau, Nathalie, Duceppe, Jean-Simon, Haché, Bruno, Jakalian, Araz, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Moreau, Elaine, Perreault, Stéphane, Stammers, Timothy, Thauvette, Louise, Warrington, Jeff, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Journal Article
An NS3 Serine Protease Inhibitor Abrogates Replication of Subgenomic Hepatitis C Virus RNA
Pause, Arnim, Kukolj, George, Bailey, Murray, Brault, Martine, Dô, Florence, Halmos, Ted, Lagacé, Lisette, Maurice, Roger, Marquis, Martin, McKercher, Ginette, Pellerin, Charles, Pilote, Louise, Thibeault, Diane, Lamarre, Daniel
Published in The Journal of biological chemistry (30.05.2003)
Published in The Journal of biological chemistry (30.05.2003)
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Journal Article
The Immune Landscape of Cancer
Bortone, Dante S., Eddy, James A., Liu, Yuexin, Weinstein, John N., Holt, Robert A., Zenklusen, Jean C., Cho, Juok, Reynolds, Sheila, Liu, Wenbin, Ryan, Michael, Chakravarty, Debyani, Schultz, Nikolaus, Stuart, Joshua M., Wilkerson, Matthew D., Balasundaram, Miruna, Carlsen, Rebecca, Chuah, Eric, Holt, Robert, Lee, Darlene, Ha, Gavin, Schumacher, Steven E., Cope, Leslie, Balu, Saianand, Shi, Yan, Hinoue, Toshinori, Glenn, Robert, Miller, Christopher A., Curley, Erin, Mallery, David, Morris, Scott, Longatto-Filho, Adhemar, Reis, Rui M., Scapulatempo-Neto, Cristovam, Singh, Rosy, Le, Xuan, Thorp, Richard, Setdikova, Galiya, Shabunin, Alexey, Barrett, Wendi, Ostrom, Quinn T., Karlan, Beth Y., Hu, Hai, Latour, Mathieu, Lacombe, Louis, Su, Tao, Signoretti, Sabina, Marks, Jeffrey, Olson, Jeffrey J., Sica, Gabriel, Stoop, Hans, Pollo, Bianca, Aymerich, Marta, Stepa, Serghei, Moser, Catherine, Roberts, Lewis, Czerniak, Bogdan, Lazar, Alexander J., Jakrot, Valerie, Scolyer, Richard, Thompson, John, Wilmott, James, Reuter, Victor, Tien, Nguyen Viet, Park, Joong-Won, Pinto, Peter A., Moncrieff, Marc, Botnariuc, Natalia, Pirtac, Maria, Parfitt, Jeremy, Bifulco, Carlo, Antenucci, Anna, Grazi, Gianluca, Marino, Mirella, Chevalier, Simone, McKercher, Ginette, Naska, Theresa, Borgia, Jeffrey A., Pool, Mark, Junker, Kerstin, Moiseenko, Fedor, Hilty, Joe, Pilarski, Robert, Porten, Sima, Asa, Sylvia L., Schadendorf, Dirk, Disaia, Philip, Kelley, Robin K., Sifri, Suzanne, Mannelli, Massimo, Knutson, Tina, Sigmund, Rita, Postier, Russel, Walker, Joan, Feldman, Michael, Luketich, James, Rozek, Laura, Fong, Kwun M., Hooke, Jeffrey A., Govindan, Ramaswamy, Aredes, Natália D.
Published in Immunity (Cambridge, Mass.) (17.04.2018)
Published in Immunity (Cambridge, Mass.) (17.04.2018)
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A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
Berger, Ashton C., Gunaratne, Preethi H., Wang, Chen, Kuderer, Nicole M., Ojesina, Akinyemi I., Chen, Ting-Wen, Liu, Liang, Vellano, Christopher P., Caesar-Johnson, Samantha J., Demchok, John A., Kasapi, Melpomeni, Ferguson, Martin L., Yang, Liming, Gehlenborg, Nils, Noble, Michael S., Dhankani, Varsha, Knijnenburg, Theo, Liu, Yuexin, Kanchi, Rupa S., Ling, Shiyun, de Bruijn, Ino, Heins, Zachary J., Ladanyi, Marc, Sun, Yichao, Dhalla, Noreen, Mungall, Andrew J., Sipahimalani, Payal, Beroukhim, Rameen, Kucherlapati, Raju S., Danilova, Ludmila, Bootwalla, Moiz S., Maglinte, Dennis T., Fan, Cheng, Covington, Kyle, Donehower, Lawrence A., Drummond, Jennifer, Liu, Xiuping, Hess, Julian, Appelbaum, Elizabeth L., Bailey, Matthew, Fulton, Lucinda A., Kandoth, Cyriac, Mardis, Elaine R., Penny, Robert, Lichtenberg, Tara M., Zmuda, Erik, de Carvalho, Ana C., Fregnani, José H., Barnholtz-Sloan, Jill S., Eckman, John, Rabeno, Brenda, Bergeron, Alain, Desjardins, Laurence, Sastre, Xavier, Bigner, Darell, McLendon, Roger, Secord, Angeles, Brat, Daniel J., Force, Seth, Khuri, Fadlo, Zwarthoff, Ellen C., Finocchiaro, Gaetano, Perin, Alessandro, Wiznerowicz, Maciej, Baudin, Eric, Noushmehr, Houtan, Birrer, Michael, Copland, John A., Ho, Thai, Zhang, Lizhi, Meric-Bernstam, Funda, Sood, Anil, Carter, Candace, Shannon, Kerwin, Mirsaidi, Cyrus, Zaren, Howard, Hung, Nguyen Phi, Metwalli, Adam R., Tcaciuc, Diana, Rassl, Doris M., Farver, Carol, Schilero, Cathy, Manikhas, George, Janssen, Klaus-Peter, Abdel-Rahman, Mohamed H., Lehman, Norman L., Mandt, Randy, Nguyen, Phuong, Rai, Karan, Powers, James, Fehrenbach, Ashley, von Deimling, Andreas, Galbraith, Joseph, Adebamowo, Sally N., Boussioutas, Alex, Zuna, Rosemary, Rubin, Mark A., Weinstein, John N., Levine, Douglas A., Akbani, Rehan
Published in Cancer cell (09.04.2018)
Published in Cancer cell (09.04.2018)
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Long term evaluation of optimized Gleason grading in a large cohort of men with prostate cancer in Canada
Wissing, Michel, Brimo, Fadi, McKercher, Ginette, Scarlata, Eleonora, Saad, Fred, Carmel, Michel, Lacombe, Louis, Têtu, Bernard, Ekindi-Ndongo, Nadia, Latour, Mathieu, Trudel, Dominique, Chevalier, Simone, Aprikian, Armen
Published in Human pathology (01.04.2024)
Published in Human pathology (01.04.2024)
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A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
Rao, Shuyun, Gough, Nancy R., Roszik, Jason, Ravikumar, Visweswaran, Ohshiro, Kazufumi, Nguyen, Bao-Ngoc, Ajani, Jaffer A., Wiznerowicz, Maciej, Wu, Ye, Liu, Yuexin, Kanchi, Rupa S., Zhang, Jiexin, Gross, Benjamin E., Kundra, Ritika, Phillips, Sarah M., Zhang, Hongxin, Peto, Myron, Mungall, Andrew J., Lai, Phillip H., Van Den Berg, David J., Bodenheimer, Tom, Simons, Janae V., Veluvolu, Umadevi, Fan, Huihui, Bellair, Michelle, Dinh, Huyen, Doddapaneni, HarshaVardhan, Han, Yi, Lee, Sandra, Li, Wei, Mardis, Elaine R., Gastier-Foster, Julie M., Lichtenberg, Tara M., Le, Xuan, Thorp, Richard, Lyadov, Vladimir, De Rose, Agostino, Rabeno, Brenda, Têtu, Bernard, Chabot, John, Hibshoosh, Hanina, Potapova, Olga, Mariani, Odette, Bigner, Darell, Stoop, Hans, Cuppini, Lucia, Finocchiaro, Gaetano, Murawa, Dawid, Guillermo, Armando López, Akeredolu, Teniola, Birrer, Michael, Nagorney, David, Stanton, Melissa, Yang, Ju Dong, Angulo Gonzalez, Ana Maria, Bondaruk, Jolanta, Broaddus, Russell, Guo, Charles, Lazar, Alexander J., Meric-Bernstam, Funda, Tsao, Anne, Carter, Candace, Haydu, Lauren, Hersey, Peter, Stretch, Jonathan, Synott, Maria, Drwiega, Paul, Hung, Nguyen Phi, Kebebew, Electron, Metwalli, Adam R., Schmidt, Laura S., Cernat, Mircea, Gorincioi, Ghenadie, Tamakawa, Raina, Chevalier, Simone, McKercher, Ginette, Smolenski, Kathy, Alvaro, Domenico, Bragazzi, Maria Consiglia, Cardinale, Vincenzo, Chesla, David, Cottingham, Sandra, Lehman, Norman L., Powers, James, Huland, Hartwig, Sauter, Guido, Carroll, Peter R., Forgie, Ian, Carney, Michael, Knutson, Tina, Godwin, Andrew K., Boussioutas, Alex, Saad, Fred, Bocklage, Therese, Feldman, Michael, Valdivieso, Federico, Dhir, Rajiv, Sankarankuty, Ajith, Fantacone-Campbell, J. Leigh, Rubin, Mark A.
Published in Cell systems (24.10.2018)
Published in Cell systems (24.10.2018)
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Optimization of the 2014 Gleason grade grouping in a Canadian cohort of patients with localized prostate cancer
Wissing, Michel, Brimo, Fadi, Chevalier, Simone, Scarlata, Eleonora, McKercher, Ginette, O'Flaherty, Ana, Aprikian, Saro, Thibodeau, Valérie, Saad, Fred, Carmel, Michel, Lacombe, Louis, Têtu, Bernard, Ekindi‐Ndongo, Nadia, Latour, Mathieu, Trudel, Dominique, Aprikian, Armen
Published in BJU international (01.04.2019)
Published in BJU international (01.04.2019)
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Journal Article
Psychosocial adjustment to a prostate cancer diagnosis in a cohort of radical prostatectomy patients in Quebec, Canada
Wissing, Michel D., Chevalier, Simone, O'Flaherty, Ana, McKercher, Ginette, Aprikian, Saro, Saad, Fred, Carmel, Michel, Lacombe, Louis, Hamel, Marc, Aprikian, Armen
Published in Psycho-oncology (Chichester, England) (01.04.2019)
Published in Psycho-oncology (Chichester, England) (01.04.2019)
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The relationship between body-mass index, physical activity, and pathologic and clinical outcomes after radical prostatectomy for prostate cancer
Wissing, Michel, Chevalier, Simone, McKercher, Ginette, Laprise, Claudie, Aprikian, Saro, O’Flaherty, Ana, Scarlata, Eleonora, Saad, Fred, Carmel, Michel, Lacombe, Louis, Brimo, Fadi, Latour, Mathieu, Ekindi-Ndongo, Nadia, Têtu, Bernard, Aprikian, Armen
Published in World journal of urology (01.05.2019)
Published in World journal of urology (01.05.2019)
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Journal Article
Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L, Bös, Michael, Cordingley, Michael G, Chabot, Catherine, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Jolicoeur, Eric, LaPlante, Steven, McKercher, Ginette, Poirier, Martin, Poupart, Marc-André, Tsantrizos, Youla S, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
The Immune Landscape of Cancer
Bortone, Dante S., Eddy, James A., Liu, Yuexin, Weinstein, John N., Holt, Robert A., Zenklusen, Jean C., Cho, Juok, Reynolds, Sheila, Liu, Wenbin, Ryan, Michael, Chakravarty, Debyani, Schultz, Nikolaus, Stuart, Joshua M., Wilkerson, Matthew D., Balasundaram, Miruna, Carlsen, Rebecca, Chuah, Eric, Holt, Robert, Lee, Darlene, Ha, Gavin, Schumacher, Steven E., Cope, Leslie, Balu, Saianand, Shi, Yan, Hinoue, Toshinori, Glenn, Robert, Miller, Christopher A., Curley, Erin, Mallery, David, Morris, Scott, Longatto-Filho, Adhemar, Reis, Rui M., Scapulatempo-Neto, Cristovam, Singh, Rosy, Le, Xuan, Thorp, Richard, Setdikova, Galiya, Shabunin, Alexey, Barrett, Wendi, Ostrom, Quinn T., Karlan, Beth Y., Hu, Hai, Latour, Mathieu, Lacombe, Louis, Su, Tao, Signoretti, Sabina, Marks, Jeffrey, Olson, Jeffrey J., Sica, Gabriel, Stoop, Hans, Pollo, Bianca, Aymerich, Marta, Stepa, Serghei, Moser, Catherine, Roberts, Lewis, Czerniak, Bogdan, Lazar, Alexander J., Jakrot, Valerie, Scolyer, Richard, Thompson, John, Wilmott, James, Reuter, Victor, Tien, Nguyen Viet, Park, Joong-Won, Pinto, Peter A., Moncrieff, Marc, Botnariuc, Natalia, Pirtac, Maria, Parfitt, Jeremy, Bifulco, Carlo, Antenucci, Anna, Grazi, Gianluca, Marino, Mirella, Chevalier, Simone, McKercher, Ginette, Naska, Theresa, Borgia, Jeffrey A., Pool, Mark, Junker, Kerstin, Moiseenko, Fedor, Hilty, Joe, Pilarski, Robert, Porten, Sima, Asa, Sylvia L., Schadendorf, Dirk, Disaia, Philip, Kelley, Robin K., Sifri, Suzanne, Mannelli, Massimo, Knutson, Tina, Sigmund, Rita, Postier, Russel, Walker, Joan, Feldman, Michael, Luketich, James, Rozek, Laura, Fong, Kwun M., Hooke, Jeffrey A., Govindan, Ramaswamy, Aredes, Natália D.
Published in Immunity (Cambridge, Mass.) (20.08.2019)
Published in Immunity (Cambridge, Mass.) (20.08.2019)
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Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency
Hucke, Oliver, Coulombe, René, Bonneau, Pierre, Bertrand-Laperle, Mégan, Brochu, Christian, Gillard, James, Joly, Marc-André, Landry, Serge, Lepage, Olivier, Llinàs-Brunet, Montse, Pesant, Marc, Poirier, Martin, Poirier, Maude, McKercher, Ginette, Marquis, Martin, Kukolj, George, Beaulieu, Pierre L., Stammers, Timothy A.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Integrated Strategies for Identifying Leads That Target the NS3 Helicase of the Hepatitis C Virus
LaPlante, Steven R., Padyana, Anil K., Abeywardane, Asitha, Bonneau, Pierre, Cartier, Mireille, Coulombe, René, Jakalian, Araz, Wildeson-Jones, Jessi, Li, Xiang, Liang, Shuang, McKercher, Ginette, White, Peter, Zhang, Qiang, Taylor, Steven J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection
Beaulieu, Pierre L, Anderson, Paul C, Bethell, Richard, Bös, Michael, Bousquet, Yves, Brochu, Christian, Cordingley, Michael G, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Kawai, Stephen, Marquis, Martin, McKercher, Ginette, Poupart, Marc-André, Stammers, Timothy, Thavonekham, Bounkham, Wernic, Dominik, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors
Stammers, Timothy A., Coulombe, René, Rancourt, Jean, Thavonekham, Bounkham, Fazal, Gulrez, Goulet, Sylvie, Jakalian, Araz, Wernic, Dominic, Tsantrizos, Youla, Poupart, Marc-André, Bös, Michael, McKercher, Ginette, Thauvette, Louise, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Discovery and Synthesis of C‑Nucleosides as Potential New Anti-HCV Agents
Draffan, Alistair G, Frey, Barbara, Pool, Brett, Gannon, Carlie, Tyndall, Edward M, Lilly, Michael, Francom, Paula, Hufton, Richard, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Nguyen, Van T. T, Jeynes, Tyrone P, Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Thomas, Jesse D, Pryor, Melinda, Porter, Kate, Morton, Craig J, Lin, Bo, Duan, Jianmin, Kukolj, George, Simoneau, Bruno, McKercher, Ginette, Lagacé, Lisette, Amad, Ma’an, Bethell, Richard C, Tucker, Simon P
Published in ACS medicinal chemistry letters (12.06.2014)
Published in ACS medicinal chemistry letters (12.06.2014)
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Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: Improved drug-like properties through C-2 SAR in three sub-series
Beaulieu, Pierre L., Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Gillard, James, McKercher, Ginette, LaPlante, Steven, Lagacée, Lisette, Thauvette, Louise, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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