Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity
Sharma, Arun, McKeithan, Wesley L., Serrano, Ricardo, Kitani, Tomoya, Burridge, Paul W., del Álamo, Juan C., Mercola, Mark, Wu, Joseph C.
Published in Nature protocols (01.12.2018)
Published in Nature protocols (01.12.2018)
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A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay
Seeger, Timon, Shrestha, Rajani, Lam, Chi Keung, Chen, Caressa, McKeithan, Wesley L, Lau, Edward, Wnorowski, Alexa, McMullen, George, Greenhaw, Matthew, Lee, Jaecheol, Oikonomopoulos, Angelos, Lee, Soah, Yang, Huaxiao, Mercola, Mark, Wheeler, Matthew, Ashley, Euan A, Yang, Fan, Karakikes, Ioannis, Wu, Joseph C
Published in Circulation (New York, N.Y.) (05.02.2019)
Published in Circulation (New York, N.Y.) (05.02.2019)
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Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
McKeithan, Wesley L., Feyen, Dries A.M., Bruyneel, Arne A.N., Okolotowicz, Karl J., Ryan, Daniel A., Sampson, Kevin J., Potet, Franck, Savchenko, Alex, Gómez-Galeno, Jorge, Vu, Michelle, Serrano, Ricardo, George, Alfred L., Kass, Robert S., Cashman, John R., Mercola, Mark
Published in Cell stem cell (05.11.2020)
Published in Cell stem cell (05.11.2020)
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Id genes are essential for early heart formation
Cunningham, Thomas J, Yu, Michael S, McKeithan, Wesley L, Spiering, Sean, Carrette, Florent, Huang, Chun-Teng, Bushway, Paul J, Tierney, Matthew, Albini, Sonia, Giacca, Mauro, Mano, Miguel, Puri, Pier Lorenzo, Sacco, Alessandra, Ruiz-Lozano, Pilar, Riou, Jean-Francois, Umbhauer, Muriel, Duester, Gregg, Mercola, Mark, Colas, Alexandre R
Published in Genes & development (01.07.2017)
Published in Genes & development (01.07.2017)
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Will iPSC-cardiomyocytes revolutionize the discovery of drugs for heart disease?
Bruyneel, Arne AN, McKeithan, Wesley L, Feyen, Dries AM, Mercola, Mark
Published in Current opinion in pharmacology (01.10.2018)
Published in Current opinion in pharmacology (01.10.2018)
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An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes
McKeithan, Wesley L, Savchenko, Alex, Yu, Michael S, Cerignoli, Fabio, Bruyneel, Arne A N, Price, Jeffery H, Colas, Alexandre R, Miller, Evan W, Cashman, John R, Mercola, Mark
Published in Frontiers in physiology (11.10.2017)
Published in Frontiers in physiology (11.10.2017)
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Journal Article
Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs
Gomez‐Galeno, Jorge, Okolotowicz, Karl, Johnson, Mark, McKeithan, Wesley L., Mercola, Mark, Cashman, John R.
Published in Pharmacology research & perspectives (01.08.2021)
Published in Pharmacology research & perspectives (01.08.2021)
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High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
Sharma, Arun, Burridge, Paul W, McKeithan, Wesley L, Serrano, Ricardo, Shukla, Praveen, Sayed, Nazish, Churko, Jared M, Kitani, Tomoya, Wu, Haodi, Holmström, Alexandra, Matsa, Elena, Zhang, Yuan, Kumar, Anusha, Fan, Alice C, Del Álamo, Juan C, Wu, Sean M, Moslehi, Javid J, Mercola, Mark, Wu, Joseph C
Published in Science translational medicine (15.02.2017)
Published in Science translational medicine (15.02.2017)
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Programming multicellular assembly with synthetic cell adhesion molecules
Stevens, Adam J., Harris, Andrew R., Gerdts, Josiah, Kim, Ki H., Trentesaux, Coralie, Ramirez, Jonathan T., McKeithan, Wesley L., Fattahi, Faranak, Klein, Ophir D., Fletcher, Daniel A., Lim, Wendell A.
Published in Nature (London) (02.02.2023)
Published in Nature (London) (02.02.2023)
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Journal Article
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
Feyen, Dries A.M., McKeithan, Wesley L., Bruyneel, Arne A.N., Spiering, Sean, Hörmann, Larissa, Ulmer, Bärbel, Zhang, Hui, Briganti, Francesca, Schweizer, Michaela, Hegyi, Bence, Liao, Zhandi, Pölönen, Risto-Pekka, Ginsburg, Kenneth S., Lam, Chi Keung, Serrano, Ricardo, Wahlquist, Christine, Kreymerman, Alexander, Vu, Michelle, Amatya, Prashila L., Behrens, Charlotta S., Ranjbarvaziri, Sara, Maas, Renee G.C., Greenhaw, Matthew, Bernstein, Daniel, Wu, Joseph C., Bers, Donald M., Eschenhagen, Thomas, Metallo, Christian M., Mercola, Mark
Published in Cell reports (Cambridge) (21.07.2020)
Published in Cell reports (Cambridge) (21.07.2020)
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Journal Article
Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs
Johnson, Mark, Gomez-Galeno, Jorge, Ryan, Daniel, Okolotowicz, Karl, McKeithan, Wesley L., Sampson, Kevin J., Kass, Robert S., Mercola, Mark, Cashman, John R.
Published in Bioorganic & medicinal chemistry letters (15.08.2021)
Published in Bioorganic & medicinal chemistry letters (15.08.2021)
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Journal Article
Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes
Cashman, John R, Ryan, Daniel, McKeithan, Wesley L, Okolotowicz, Karl, Gomez-Galeno, Jorge, Johnson, Mark, Sampson, Kevin J, Kass, Robert S, Pezhouman, Arash, Karagueuzian, Hrayr S, Mercola, Mark
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis
Colas, Alexandre R, McKeithan, Wesley L, Cunningham, Thomas J, Bushway, Paul J, Garmire, Lana X, Duester, Gregg, Subramaniam, Shankar, Mercola, Mark
Published in Genes & development (01.12.2012)
Published in Genes & development (01.12.2012)
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Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness
Cheng, Jiongjia, Tsuda, Masanao, Okolotowicz, Karl, Dwyer, Mary, Bushway, Paul J., Colas, Alexandre R., Lancman, Joseph J., Schade, Dennis, Perea-Gil, Isaac, Bruyneel, Arne A.N., Lee, Jaechol, Vadgama, Nirmal, Quach, Justine, McKeithan, Wesley L., Biechele, Travis L., Wu, Joseph C., Moon, Randall T., Si Dong, P. Duc, Karakikes, Ioannis, Cashman, John R., Mercola, Mark
Published in Cell chemical biology (20.05.2021)
Published in Cell chemical biology (20.05.2021)
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Journal Article
Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function
Bruyneel, Arne A. N., McKeithan, Wesley L., Feyen, Dries A. M., Mercola, Mark
Published in Current cardiology reports (01.07.2018)
Published in Current cardiology reports (01.07.2018)
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Journal Article
Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening
McKeithan, Wesley L, Colas, Alexandre R, Bushway, Paul J, Ray, Saugata, Mercola, Mark
Published in Current protocols in stem cell biology (01.11.2012)
Published in Current protocols in stem cell biology (01.11.2012)
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Journal Article
Author Correction: Pan-cancer analysis of whole genomes
Aaltonen, Lauri A., Abascal, Federico, Abeshouse, Adam, Aburatani, Hiroyuki, Adams, David J., Agrawal, Nishant, Ahn, Keun Soo, Ahn, Sung-Min, Aikata, Hiroshi, Akbani, Rehan, Akdemir, Kadir C., Al-Ahmadie, Hikmat, Al-Sedairy, Sultan T., Al-Shahrour, Fatima, Alawi, Malik, Albert, Monique, Aldape, Kenneth, Alexandrov, Ludmil B., Ally, Adrian, Alsop, Kathryn, Alvarez, Eva G., Amary, Fernanda, Amin, Samirkumar B., Aminou, Brice, Ammerpohl, Ole, Anderson, Matthew J., Ang, Yeng, Antonello, Davide, Anur, Pavana, Aparicio, Samuel, Appelbaum, Elizabeth L., Arai, Yasuhito, Aretz, Axel, Arihiro, Koji, Ariizumi, Shun-ichi, Armenia, Joshua, Arnould, Laurent, Asa, Sylvia, Assenov, Yassen, Atwal, Gurnit, Aukema, Sietse, Auman, J. Todd, Aure, Miriam R. R., Awadalla, Philip, Aymerich, Marta, Bader, Gary D., Baez-Ortega, Adrian, Bailey, Matthew H., Bailey, Peter J., Balasundaram, Miruna, Balu, Saianand, Bandopadhayay, Pratiti, Banks, Rosamonde E., Barbi, Stefano, Barbour, Andrew P., Barenboim, Jonathan, Barnholtz-Sloan, Jill, Barr, Hugh, Barrera, Elisabet, Bartlett, John, Bartolome, Javier, Bassi, Claudio, Bathe, Oliver F., Baumhoer, Daniel, Bavi, Prashant, Baylin, Stephen B., Bazant, Wojciech, Beardsmore, Duncan, Beck, Timothy A., Behjati, Sam, Behren, Andreas, Niu, Beifang, Bell, Cindy, Beltran, Sergi, Benz, Christopher, Berchuck, Andrew, Bergmann, Anke K., Bergstrom, Erik N., Berman, Benjamin P., Berney, Daniel M., Bernhart, Stephan H., Beroukhim, Rameen, Berrios, Mario, Bersani, Samantha, Bertl, Johanna, Betancourt, Miguel, Bhandari, Vinayak, Bhosle, Shriram G., Biankin, Andrew V., Bieg, Matthias, Bigner, Darell, Binder, Hans, Birney, Ewan, Birrer, Michael, Biswas, Nidhan K., Bjerkehagen, Bodil, Bodenheimer, Tom, Boice, Lori, Bonizzato, Giada, De Bono, Johann S.
Published in Nature (London) (16.02.2023)
Published in Nature (London) (16.02.2023)
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