Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
Bledsoe, Randy K., Montana, Valerie G., Stanley, Thomas B., Delves, Chris J., Apolito, Christopher J., McKee, David D., Consler, Thomas G., Parks, Derek J., Stewart, Eugene L., Willson, Timothy M., Lambert, Millard H., Moore, John T., Pearce, Kenneth H., Xu, H.Eric
Published in Cell (12.07.2002)
Published in Cell (12.07.2002)
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Journal Article
Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors
Moore, Linda B, Maglich, Jodi M, McKee, David D, Wisely, Bruce, Willson, Timothy M, Kliewer, Steven A, Lambert, Millard H, Moore, John T
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2002)
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2002)
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Journal Article
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Kliewer, Steven A, Moore, John T, Wade, Laura, Staudinger, Jeff L, Watson, Michael A, Jones, Stacey A, McKee, David D, Oliver, Beverly B, Willson, Timothy M, Zetterström, Rolf H, Perlmann, Thomas, Lehmann, Jürgen M
Published in Cell (1998)
Published in Cell (1998)
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Journal Article
Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes
Maglich, J M, Sluder, A, Guan, X, Shi, Y, McKee, D D, Carrick, K, Kamdar, K, Willson, T M, Moore, J T
Published in Genome biology (24.07.2001)
Published in Genome biology (24.07.2001)
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Journal Article
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Goodwin, Bryan, Jones, Stacey A., Price, Roger R., Watson, Michael A., McKee, David D., Moore, Linda B., Galardi, Cristin, Wilson, Joan G., Lewis, Michael C., Roth, Matthew E., Maloney, Patrick R., Willson, Timothy M., Kliewer, Steven A.
Published in Molecular cell (01.09.2000)
Published in Molecular cell (01.09.2000)
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Journal Article
X-ray Crystal Structures of the Estrogen-related Receptor-γ Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation
Wang, Liping, Zuercher, William J., Consler, Thomas G., Lambert, Millard H., Miller, Aaron B., Orband-Miller, Lisa A., McKee, David D., Willson, Timothy M., Nolte, Robert T.
Published in The Journal of biological chemistry (08.12.2006)
Published in The Journal of biological chemistry (08.12.2006)
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Journal Article
Regulation of the Human CYP2B6 Gene by the Nuclear Pregnane X Receptor
Goodwin, B, Moore, L B, Stoltz, C M, McKee, D D, Kliewer, S A
Published in Molecular pharmacology (01.09.2001)
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Published in Molecular pharmacology (01.09.2001)
Journal Article
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR α
Xu, H. Eric, Stanley, Thomas B, Montana, Valerie G, Lambert, Millard H, Shearer, Barry G, Cobb, Jeffery E, McKee, David D, Galardi, Cristin M, Plunket, Kelli D, Nolte, Robert T, Parks, Derek J, Moore, John T, Kliewer, Steven A, Willson, Timothy M, Stimmel, Julie B
Published in Nature (London) (07.02.2002)
Published in Nature (London) (07.02.2002)
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Journal Article
The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution
Jones, Stacey A, Moore, Linda B, Shenk, Jennifer L, Wisely, G. Bruce, Hamilton, Geraldine A, McKee, David D, Tomkinson, Nicholas C. O, LeCluyse, Edward L, Lambert, Millard H, Willson, Timothy M, Kliewer, Steven A, Moore, John T
Published in Molecular endocrinology (Baltimore, Md.) (01.01.2000)
Published in Molecular endocrinology (Baltimore, Md.) (01.01.2000)
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Journal Article
BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution
Pearce, Kenneth H., Overton, Laurie K., Gampe, Robert T., Barrett, George B., Taylor, J. David, McKee, David D., Campobasso, Nino, Nolte, Robert T., Reid, Robert A.
Published in Acta crystallographica. Section F, Structural biology communications (01.04.2019)
Published in Acta crystallographica. Section F, Structural biology communications (01.04.2019)
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Journal Article
Structural Determinants of Ligand Binding Selectivity between the Peroxisome Proliferator-Activated Receptors
Xu, H. Eric, Lambert, Millard H., Montana, Valerie G., Plunket, Kelli D., Moore, Linda B., Collins, Jon L., Oplinger, Jeffery A., Kliewer, Steven A., Gampe, Robert T., McKee, David D., Moore, John T., Willson, Timothy M.
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2001)
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Journal Article
X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch
Williams, Shawn, Bledsoe, Randy K, Collins, Jon L, Boggs, Sharon, Lambert, Millard H, Miller, Ann B, Moore, John, McKee, David D, Moore, Linda, Nichols, Jason, Parks, Derek, Watson, Mike, Wisely, Bruce, Willson, Timothy M
Published in The Journal of biological chemistry (18.07.2003)
Published in The Journal of biological chemistry (18.07.2003)
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Journal Article
Design, synthesis, and DNA binding properties of bifunctional intercalators. Comparison of polymethylene and diphenyl ether chains connecting phenanthridine
Cory, M, McKee, David D, Kagan, J, Henry D. W, Miller, J. Allen
Published in Journal of the American Chemical Society (01.04.1985)
Published in Journal of the American Chemical Society (01.04.1985)
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Journal Article
Structure of the Tie2 RTK Domain: Self-Inhibition by the Nucleotide Binding Loop, Activation Loop, and C-Terminal Tail
Shewchuk, Lisa M, Hassell, Anne M, Ellis, Byron, Holmes, W.D, Davis, Roderick, Horne, Earnest L, Kadwell, Sue H, McKee, David D, Moore, John T
Published in Structure (London) (15.11.2000)
Published in Structure (London) (15.11.2000)
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Journal Article
Pharmacophore Analysis of the Nuclear Oxysterol Receptor LXRα
Spencer, Thomas A, Li, Dansu, Russel, Jonathon S, Collins, Jon L, Bledsoe, Randy K, Consler, Thomas G, Moore, Linda B, Galardi, Cristin M, McKee, David D, Moore, John T, Watson, Michael A, Parks, Derek J, Lambert, Millard H, Willson, Timothy M
Published in Journal of medicinal chemistry (15.03.2001)
Published in Journal of medicinal chemistry (15.03.2001)
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[(1-Pyrenylmethyl)amino] alcohols, a new class of antitumor DNA intercalators. Discovery and initial amine side chain structure-activity studies
Bair, Kenneth W, Tuttle, Richard L, Knick, Vincent C, Cory, Michael, McKee, David D
Published in Journal of medicinal chemistry (01.09.1990)
Published in Journal of medicinal chemistry (01.09.1990)
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Journal Article
2-[(Arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding
Bair, Kenneth W, Andrews, C. Webster, Tuttle, Richard L, Knick, Vincent C, Cory, Michael, McKee, David D
Published in Journal of medicinal chemistry (01.07.1991)
Published in Journal of medicinal chemistry (01.07.1991)
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Journal Article
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
Lehmann, J M, McKee, D D, Watson, M A, Willson, T M, Moore, J T, Kliewer, S A
Published in The Journal of clinical investigation (01.09.1998)
Published in The Journal of clinical investigation (01.09.1998)
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Journal Article
Cloning and Characterization of Human Estrogen Receptor β Isoforms
Moore, John T., McKee, David D., Slentz-Kesler, Kimberly, Moore, Linda B., Jones, Stacey A., Horne, Earnest L., Su, Jui-Lan, Kliewer, Steven A., Lehmann, Jürgen M., Willson, Timothy M.
Published in Biochemical and biophysical research communications (09.06.1998)
Published in Biochemical and biophysical research communications (09.06.1998)
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