Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery
González-Cestari, Tatiana F, Henderson, Brandon J, Pavlovicz, Ryan E, McKay, Susan B, El-Hajj, Raed A, Pulipaka, Aravinda B, Orac, Crina M, Reed, Damon D, Boyd, R Thomas, Zhu, Michael X, Li, Chenglong, Bergmeier, Stephen C, McKay, Dennis B
Published in The Journal of pharmacology and experimental therapeutics (01.02.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2009)
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Journal Article
Analogs of Methyllycaconitine as Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmacophore Development
McKay, Dennis B, Chang, Cheng, González-Cestari, Tatiana F, McKay, Susan B, El-Hajj, Raed A, Bryant, Darrell L, Zhu, Michael X, Swaan, Peter W, Arason, Kristjan M, Pulipaka, Aravinda B, Orac, Crina M, Bergmeier, Stephen C
Published in Molecular pharmacology (01.05.2007)
Published in Molecular pharmacology (01.05.2007)
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Journal Article
Alkaloids from Microcos paniculata with Cytotoxic and Nicotinic Receptor Antagonistic Activities
Still, Patrick C, Yi, Bitna, González-Cestari, Tatiana F, Pan, Li, Pavlovicz, Ryan E, Chai, Hee-Byung, Ninh, Tran Ngoc, Li, Chenglong, Soejarto, Djaja Djendoel, McKay, Dennis B, Kinghorn, A. Douglas
Published in Journal of natural products (Washington, D.C.) (22.02.2013)
Published in Journal of natural products (Washington, D.C.) (22.02.2013)
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Journal Article
Structure–activity studies with ring E analogues of methyllycaconitine on bovine adrenal α3β4 nicotinic receptors
Bryant, Darrell L, Free, R.Benjamin, Thomasy, Sara M, Lapinsky, David J, Ismail, Khadiga A, McKay, Susan B, Bergmeier, Stephen C, McKay, Dennis B
Published in Neuroscience research (2002)
Published in Neuroscience research (2002)
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Journal Article
Structure–Activity Relationship Studies of Sulfonylpiperazine Analogues as Novel Negative Allosteric Modulators of Human Neuronal Nicotinic Receptors
Henderson, Brandon J, Carper, Daniel J, González-Cestari, Tatiana F, Yi, Bitna, Mahasenan, Kiran, Pavlovicz, Ryan E, Dalefield, Martin L, Coleman, Robert S, Li, Chenglong, McKay, Dennis B
Published in Journal of medicinal chemistry (22.12.2011)
Published in Journal of medicinal chemistry (22.12.2011)
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Journal Article
3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human alpha 4 beta 2 neuronal nicotinic acetylcholine receptors
Henderson, Brandon J, Orac, Crina M, Maciagiewicz, Iwona, Bergmeier, Stephen C, McKay, Dennis B
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors
Henderson, Brandon J., Orac, Crina M., Maciagiewicz, Iwona, Bergmeier, Stephen C., McKay, Dennis B.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: Pharmacophore modeling and structure–activity relationship studies
Yi, Bitna, Long, Sihui, González-Cestari, Tatiana F., Henderson, Brandon J., Pavlovicz, Ryan E., Werbovetz, Karl, Li, Chenglong, McKay, Dennis B.
Published in Bioorganic & medicinal chemistry (01.08.2013)
Published in Bioorganic & medicinal chemistry (01.08.2013)
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Journal Article
Evidence for the involvement of adenomatous polyposis coli (APC) protein in maintaining cellular distributions of α3β4 nicotinic receptors
Potaros, Tulaya, Phornchirasilp, Srichan, McKay, Susan B., González-Cestari, Tatiana F., Boyd, R. Thomas, McKay, Dennis B.
Published in Neuroscience letters (04.02.2011)
Published in Neuroscience letters (04.02.2011)
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Journal Article
Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening
Mahasenan, Kiran V, Pavlovicz, Ryan E, Henderson, Brandon J, González-Cestari, Tatiana F, Yi, Bitna, McKay, Dennis B, Li, Chenglong
Published in ACS medicinal chemistry letters (10.11.2011)
Published in ACS medicinal chemistry letters (10.11.2011)
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Journal Article
Defining the Putative Inhibitory Site for a Selective Negative Allosteric Modulator of Human α4β2 Neuronal Nicotinic Receptors
Henderson, Brandon J, González-Cestari, Tatiana F, Yi, Bitna, Pavlovicz, Ryan E, Boyd, R. Thomas, Li, Chenglong, Bergmeier, Stephen C, McKay, Dennis B
Published in ACS chemical neuroscience (19.09.2012)
Published in ACS chemical neuroscience (19.09.2012)
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Journal Article
Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the α3β4 nicotinic acetylcholine receptors through modifications to the ester
BERGMEIER, Stephen C, ISMAIL, Khadiga A, ARASON, Kristjan M, MCKAY, Susan, BRYANT, Darrell L, MCKAY, Dennis B
Published in Bioorganic & medicinal chemistry letters (16.07.2004)
Published in Bioorganic & medicinal chemistry letters (16.07.2004)
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Journal Article
β1 - and β2 -Adrenergic Signaling in Heart Failure and Cardiac Resynchronization Therapy (CRT) with Recovery of Tissue Energetics after CRT: A Large Animal Model
Pleister, Adam, Wexler, Randell K, McKay, Dennis B, Hamiln, Robert, Elton, Terry, Feldman, David S
Published in Journal of cardiac failure (01.08.2008)
Published in Journal of cardiac failure (01.08.2008)
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Journal Article
Cloning and expression of zebrafish neuronal nicotinic acetylcholine receptors
Zirger, Jeffrey M, Beattie, Christine E, McKay, Dennis B, Thomas Boyd, R
Published in Gene Expression Patterns (01.12.2003)
Published in Gene Expression Patterns (01.12.2003)
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Journal Article
Receptor protection studies comparing recombinant and native nicotinic receptors: Evidence for a subpopulation of mecamylamine-sensitive native α3β4 nicotinic receptors
Free, R. Benjamin, Kaser, Daniel J., Boyd, R. Thomas, McKay, Dennis B.
Published in Neuroscience letters (2006)
Published in Neuroscience letters (2006)
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