PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
Ronson, George E., Piberger, Ann Liza, Higgs, Martin R., Olsen, Anna L., Stewart, Grant S., McHugh, Peter J., Petermann, Eva, Lakin, Nicholas D.
Published in Nature communications (21.02.2018)
Published in Nature communications (21.02.2018)
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Microhomologies are prevalent at Cas9-induced larger deletions
Owens, Dominic D G, Caulder, Adam, Frontera, Vincent, Harman, Joe R, Allan, Alasdair J, Bucakci, Akin, Greder, Lucas, Codner, Gemma F, Hublitz, Philip, McHugh, Peter J, Teboul, Lydia, de Bruijn, Marella F T R
Published in Nucleic acids research (22.08.2019)
Published in Nucleic acids research (22.08.2019)
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Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Baddock, Hannah T, Brolih, Sanja, Yosaatmadja, Yuliana, Ratnaweera, Malitha, Bielinski, Marcin, Swift, Lonnie P, Cruz-Migoni, Abimael, Fan, Haitian, Keown, Jeremy R, Walker, Alexander P, Morris, Garrett M, Grimes, Jonathan M, Fodor, Ervin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J
Published in Nucleic acids research (22.02.2022)
Published in Nucleic acids research (22.02.2022)
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Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Yosaatmadja, Yuliana, Baddock, Hannah T, Newman, Joseph A, Bielinski, Marcin, Gavard, Angeline E, Mukhopadhyay, Shubhashish M M, Dannerfjord, Adam A, Schofield, Christopher J, McHugh, Peter J, Gileadi, Opher
Published in Nucleic acids research (20.09.2021)
Published in Nucleic acids research (20.09.2021)
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A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family
Baddock, Hannah T, Newman, Joseph A, Yosaatmadja, Yuliana, Bielinski, Marcin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J
Published in Nucleic acids research (20.09.2021)
Published in Nucleic acids research (20.09.2021)
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Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading
Amunugama, Ravindra, Willcox, Smaranda, Wu, R. Alex, Abdullah, Ummi B., El-Sagheer, Afaf H., Brown, Tom, McHugh, Peter J., Griffith, Jack D., Walter, Johannes C.
Published in Cell reports (Cambridge) (19.06.2018)
Published in Cell reports (Cambridge) (19.06.2018)
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SNM1A is crucial for efficient repair of complex DNA breaks in human cells
Swift, Lonnie P., Lagerholm, B. Christoffer, Henderson, Lucy R., Ratnaweera, Malitha, Baddock, Hannah T., Sengerova, Blanka, Lee, Sook, Cruz-Migoni, Abimael, Waithe, Dominic, Renz, Christian, Ulrich, Helle D., Newman, Joseph A., Schofield, Christopher J., McHugh, Peter J.
Published in Nature communications (25.06.2024)
Published in Nature communications (25.06.2024)
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Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair
Wang, Anderson T, Sengerová, Blanka, Cattell, Emma, Inagawa, Takabumi, Hartley, Janet M, Kiakos, Konstantinos, Burgess-Brown, Nicola A, Swift, Lonnie P, Enzlin, Jacqueline H, Schofield, Christopher J, Gileadi, Opher, Hartley, John A, McHugh, Peter J
Published in Genes & development (01.09.2011)
Published in Genes & development (01.09.2011)
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XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair
Bhagwat, Nikhil, Olsen, Anna L., Wang, Anderson T., Hanada, Katsuhiro, Stuckert, Patricia, Kanaar, Roland, D'Andrea, Alan, Niedernhofer, Laura J., McHugh, Peter J.
Published in Molecular and Cellular Biology (01.12.2009)
Published in Molecular and Cellular Biology (01.12.2009)
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Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair
Sengerová, Blanka, Wang, Anderson T., McHugh, Peter J.
Published in Cell cycle (Georgetown, Tex.) (01.12.2011)
Published in Cell cycle (Georgetown, Tex.) (01.12.2011)
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Tumor Survivin Is Downregulated by the Antisense Oligonucleotide LY2181308: A Proof-of-Concept, First-in-Human Dose Study
TALBOT, Denis C, RANSON, Malcolm, MCHUGH, Peter J, DE BONO, Johann S, MATTHEWS, Julian, SALEEM, Azeem, PRICE, Patricia, DAVIES, Joanna, LAHN, Michael, CALLIES, Sophie, ANDRE, Valérie, KADAM, Sunil, BURGESS, Michael, SLAPAK, Christopher, OLSEN, Anna L
Published in Clinical cancer research (15.12.2010)
Published in Clinical cancer research (15.12.2010)
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Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance
McHugh, Peter J, Spanswick, Victoria J, Hartley, John A
Published in The lancet oncology (01.08.2001)
Published in The lancet oncology (01.08.2001)
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A prototypical Fanconi anemia pathway in lower eukaryotes?
McHugh, Peter J., Ward, Thomas A., Chovanec, Miroslav
Published in Cell cycle (Georgetown, Tex.) (15.10.2012)
Published in Cell cycle (Georgetown, Tex.) (15.10.2012)
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SNM1/Pso2 family of ICL repair nucleases: From yeast to man
Cattell, Emma, Sengerová, Blanka, McHugh, Peter J
Published in Environmental and molecular mutagenesis (01.07.2010)
Published in Environmental and molecular mutagenesis (01.07.2010)
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