Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
Neelakantan, Harshini, Vance, Virginia, Wetzel, Michael D., Wang, Hua-Yu Leo, McHardy, Stanton F., Finnerty, Celeste C., Hommel, Jonathan D., Watowich, Stanley J.
Published in Biochemical pharmacology (01.01.2018)
Published in Biochemical pharmacology (01.01.2018)
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Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis
Alwan, Sevan N, Taylor, Alexander B, Rhodes, Jayce, Tidwell, Michael, McHardy, Stanton F, LoVerde, Philip T
Published in PLoS pathogens (10.07.2023)
Published in PLoS pathogens (10.07.2023)
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Addressing the oxamniquine in vitro-in vivo paradox to facilitate a new generation of anti-schistosome treatments
Toth, Katalin, Alwan, Sevan, Khan, Susan, McHardy, Stanton F., LoVerde, Philip T., Cameron, Michael D.
Published in International journal for parasitology -- drugs and drug resistance (01.04.2023)
Published in International journal for parasitology -- drugs and drug resistance (01.04.2023)
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Journal Article
Inhibition of Ca2+ entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation
Sun, Yuyang, Zboril, Emily K., De La Chapa, Jorge J., Chai, Xiufang, Da Conceicao, Viviane Nascimento, Valdez, Matthew C., McHardy, Stanton F., Gonzales, Cara B., Singh, Brij B.
Published in Frontiers in physiology (15.09.2022)
Published in Frontiers in physiology (15.09.2022)
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Journal Article
Rational approach to drug discovery for human schistosomiasis
LoVerde, Philip T., Alwan, Sevan N., Taylor, Alexander B., Rhodes, Jayce, Chevalier, Frédéric D., Anderson, Timothy JC, McHardy, Stanton F.
Published in International journal for parasitology -- drugs and drug resistance (01.08.2021)
Published in International journal for parasitology -- drugs and drug resistance (01.08.2021)
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Journal Article
An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans
Guzman, Meghan A, Rugel, Anastasia R, Tarpley, Reid S, Alwan, Sevan N, Chevalier, Frédéric D, Kovalskyy, Dmytro P, Cao, Xiaohang, Holloway, Stephen P, Anderson, Timothy J C, Taylor, Alexander B, McHardy, Stanton F, LoVerde, Philip T
Published in PLoS neglected tropical diseases (01.08.2020)
Published in PLoS neglected tropical diseases (01.08.2020)
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Corrigendum to “Rational approach to drug discovery for human schistosomiasis” [Int. J. Parasitol. Drugs Drug Resist. 16 (2021) 140–147]
LoVerde, Philip T., Alwan, Sevan N., Taylor, Alexander B., Rhodes, Jayce, Chevalier, Frédéric D., Anderson, Timothy Jc, McHardy, Stanton F.
Published in International journal for parasitology -- drugs and drug resistance (01.04.2022)
Published in International journal for parasitology -- drugs and drug resistance (01.04.2022)
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Journal Article
Schistosome Sulfotransferases: Mode of Action, Expression and Localization
Guzman, Meghan A., Rugel, Anastasia, Alwan, Sevan N., Tarpley, Reid, Taylor, Alexander B., Chevalier, Frédéric D., Wendt, George R., Collins, James J., Anderson, Timothy J. C., McHardy, Stanton F., LoVerde, Philip T.
Published in Pharmaceutics (06.07.2022)
Published in Pharmaceutics (06.07.2022)
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Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Rugel, Anastasia R., Guzman, Meghan A., Taylor, Alexander B., Chevalier, Frédéric D., Tarpley, Reid S., McHardy, Stanton F., Cao, Xiaohang, Holloway, Stephen P., Anderson, Timothy J.C., Hart, P. John, LoVerde, Philip T.
Published in International journal for parasitology -- drugs and drug resistance (01.08.2020)
Published in International journal for parasitology -- drugs and drug resistance (01.08.2020)
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Journal Article
A modular PROTAC design for target destruction using a degradation signal based on a single amino acid
Shanmugasundaram, Karthigayan, Shao, Peng, Chen, Han, Campos, Bismarck, McHardy, Stanton F., Luo, Tuoping, Rao, Hai
Published in The Journal of biological chemistry (11.10.2019)
Published in The Journal of biological chemistry (11.10.2019)
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Journal Article
Targeting Candida albicans filamentation for antifungal drug development
Vila, Taissa, Romo, Jesus A., Pierce, Christopher G., McHardy, Stanton F., Saville, Stephen P., Lopez-Ribot, José L.
Published in Virulence (17.02.2017)
Published in Virulence (17.02.2017)
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Asymmetric Synthesis of CIDD-0072424 via an Enantioselective Nitro-Mannich Reaction: A Central Nervous System Penetrant, Selective Small Molecule Inhibitor of Protein Kinase C Epsilon
De Kraker, Harmannus, Wang, Hua-Yu Leo, Arman, Hadi D., Renteria, Rachel N., Fleischer, Caleb N., Messing, Robert O., McHardy, Stanton F.
Published in Journal of organic chemistry (05.04.2024)
Published in Journal of organic chemistry (05.04.2024)
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Journal Article
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle
Neelakantan, Harshini, Brightwell, Camille R., Graber, Ted G., Maroto, Rosario, Wang, Hua-Yu Leo, McHardy, Stanton F., Papaconstantinou, John, Fry, Christopher S., Watowich, Stanley J.
Published in Biochemical pharmacology (01.05.2019)
Published in Biochemical pharmacology (01.05.2019)
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Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation
Romo, Jesus A, Pierce, Christopher G, Chaturvedi, Ashok K, Lazzell, Anna L, McHardy, Stanton F, Saville, Stephen P, Lopez-Ribot, Jose L
Published in mBio (05.12.2017)
Published in mBio (05.12.2017)
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Structure–Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells
Robles, Andrew J, McCowen, Shelby, Cai, Shengxin, Glassman, Michaels, Ruiz, Francisco, Cichewicz, Robert H, McHardy, Stanton F, Mooberry, Susan L
Published in Journal of medicinal chemistry (22.11.2017)
Published in Journal of medicinal chemistry (22.11.2017)
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Preclinical Development of Brain Permeable ERβ Agonist for the Treatment of Glioblastoma
Pratap, Uday P, Tidwell, Michael, Balinda, Henriette U, Clanton, Nicholas A, Yang, Xue, Viswanadhapalli, Suryavathi, Sareddy, Gangadhara R, Liang, Dong, Xie, Huan, Chen, Yidong, Lai, Zhao, Tekmal, Rajeshwar R, McHardy, Stanton F, Brenner, Andrew J, Vadlamudi, Ratna K
Published in Molecular cancer therapeutics (01.11.2023)
Published in Molecular cancer therapeutics (01.11.2023)
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