Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential
ELSEA, S. H, MCGUIRK, P. R, GOOTZ, T. D, MOYNIHAN, M, OSHEROFF, N
Published in Antimicrobial Agents and Chemotherapy (01.10.1993)
Published in Antimicrobial Agents and Chemotherapy (01.10.1993)
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Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage
Robinson, M.J. (Vanderbilt University School of Medicine, Nashville, TN), Martin, B.A, Gootz, T.D, McGuirk, P.R, Moynihan, M, Sutcliffe, J.A, Osheroff, N
Published in The Journal of biological chemistry (05.08.1991)
Published in The Journal of biological chemistry (05.08.1991)
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Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase
GOOTZ, T. D, MCGUIRK, P. R, MOYNIHAN, M. S, HASKELL, S. L
Published in Antimicrobial Agents and Chemotherapy (01.01.1994)
Published in Antimicrobial Agents and Chemotherapy (01.01.1994)
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Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents
BARRETT, J. F, GOOTZ, T. D, MCGUIRK, P. R, FARRELL, C. A, SOKOLOWSKI, S. A
Published in Antimicrobial Agents and Chemotherapy (01.10.1989)
Published in Antimicrobial Agents and Chemotherapy (01.10.1989)
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New Quinolone Compounds from Pseudonocardia sp. with Selective and Potent Anti-Helicobacter pylori Activity: Taxonomy of Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities
DEKKER, KOEN A., INAGAKI, TAISUKE, GOOTZ, THOMAS D., HUANG, LIANG H., KOJIMA, YASUHIRO, KOHLBRENNER, WILLIAM E., MATSUNAGA, YASUE, MCGUIRK, PAUL R., NOMURA, ETSUKO, SAKAKIBARA, TATSUO, SAKEMI, SHINICHI, SUZUKI, YUMIKO, YAMAUCHI, YUJI, KOJIMA, NAKAO
Published in Journal of antibiotics (01.02.1998)
Published in Journal of antibiotics (01.02.1998)
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Assays to detect and characterize human immunodeficiency virus type 1 (HIV-1) receptor antagonists, compounds that inhibit binding of the HIV-1 surface glycoprotein, gp120, to the CD4 receptor on human T lymphocytes
Clancy, J, Tait-Kamradt, A, Petitpas, J, Manousos, M, McGuirk, P R, Subashi, T, Watts, P, Wondrack, L
Published in Antimicrobial Agents and Chemotherapy (01.09.1994)
Published in Antimicrobial Agents and Chemotherapy (01.09.1994)
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In vitro activity of CP-99,219, a novel 7-(3-azabicyclo[3.1.0]hexyl) naphthyridone antimicrobial
D. Gootz, Thomas, Brighty, Katherine E., Anderson, Marge R., Schmieder, Brenda J., Haskell, Suzanne L., Sutcliffe, Joyce A., Castaldi, Michael J., McGuirk, Paul R.
Published in Diagnostic microbiology and infectious disease (01.08.1994)
Published in Diagnostic microbiology and infectious disease (01.08.1994)
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Assays to Detect and Characterize Synthetic Agents that Inhibit the ErmC Methyltransferase
CLANCY, JOANNA, SCHMIEDER, BRENDA J., PETITPAS, JOAN W., MANOUSOS, MARY, WILLIAMS, JOHN A., FAIELLA, JAMES A., GIRARD, ARTHUR E., MCGUIRK, PAUL R.
Published in Journal of antibiotics (1995)
Published in Journal of antibiotics (1995)
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Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements
Spitzner, J R, Chung, I K, Gootz, T D, McGuirk, P R, Muller, M T
Published in Molecular pharmacology (01.08.1995)
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Published in Molecular pharmacology (01.08.1995)
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Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine
McGuirk, Paul R, Jefson, Martin R, Mann, Douglas D, Elliott, Nancy C, Chang, Polly, Cisek, Eugene P, Cornell, C. Peter, Gootz, Thomas D, Haskell, Susan L
Published in Journal of medicinal chemistry (01.02.1992)
Published in Journal of medicinal chemistry (01.02.1992)
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Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinoline antibacterial agent for veterinary medicine
MCGUIRK, P. R, JEFSON, M. R, LAFLEUR, L. J, ROSENFELD, M. J, SHYOCK, T. R, SILVIA, A. M, WEBER, F. H, MANN, D. D, ELLIOTT, N. C, CHANG, P, CISEK, E. P, CORNELL, C. P, GOOTZ, T. D, HASKELL, S. L, HINDAHL, M. S
Published in Journal of medicinal chemistry (1992)
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Published in Journal of medicinal chemistry (1992)
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