SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression
McGrath, Marisa E, Xue, Yong, Taylor, Louis, Dillen, Carly, Ardanuy, Jeremy, Gonzalez-Juarbe, Norberto, Baracco, Lauren, Kim, Raymond, Hart, Rebecca, Assad-Garcia, Nacyra, Vashee, Sanjay, Frieman, Matthew B
Published in PLoS pathogens (23.05.2024)
Published in PLoS pathogens (23.05.2024)
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SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection
Li, Minghua, Ayyanathan, Kasirajan, Dittmar, Mark, Miller, Jesse, Tapescu, Iulia, Lee, Jae Seung, McGrath, Marisa E, Xue, Yong, Vashee, Sanjay, Schultz, David C, Frieman, Matthew B, Cherry, Sara
Published in mBio (28.06.2023)
Published in mBio (28.06.2023)
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Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants
Logue, James, Johnson, Robert M, Patel, Nita, Zhou, Bin, Maciejewski, Sonia, Foreman, Bryant, Zhou, Haixia, Portnoff, Alyse D, Tian, Jing-Hui, Rehman, Asma, McGrath, Marisa E, Haupt, Robert E, Weston, Stuart M, Baracco, Lauren, Hammond, Holly, Guebre-Xabier, Mimi, Dillen, Carly, Madhangi, M, Greene, Ann M, Massare, Michael J, Glenn, Greg M, Smith, Gale, Frieman, Matthew B
Published in Nature communications (28.02.2023)
Published in Nature communications (28.02.2023)
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A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8
Rodriguez-Rodriguez, Bruno A, Ciabattoni, Grace O, Duerr, Ralf, Valero-Jimenez, Ana M, Yeung, Stephen T, Crosse, Keaton M, Schinlever, Austin R, Bernard-Raichon, Lucie, Rodriguez Galvan, Joaquin, McGrath, Marisa E, Vashee, Sanjay, Xue, Yong, Loomis, Cynthia A, Khanna, Kamal M, Cadwell, Ken, Desvignes, Ludovic, Frieman, Matthew B, Ortigoza, Mila B, Dittmann, Meike
Published in Nature communications (25.05.2023)
Published in Nature communications (25.05.2023)
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PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19
Logue, James, Chakraborty, Arup R, Johnson, Robert, Goyal, Girija, Rodas, Melissa, Taylor, Louis J, Baracco, Lauren, McGrath, Marisa E, Haupt, Robert, Furlong, Brooke A, Soong, Mercy, Prabhala, Pranav, Horvath, Viktor, Carlson, Kenneth E, Weston, Stuart, Ingber, Donald E, DePamphilis, Melvin L, Frieman, Matthew B
Published in Communications biology (12.08.2022)
Published in Communications biology (12.08.2022)
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mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
Nanishi, Etsuro, McGrath, Marisa E., O’Meara, Timothy R., Barman, Soumik, Yu, Jingyou, Wan, Huahua, Dillen, Carly A., Menon, Manisha, Seo, Hyuk-Soo, Song, Kijun, Xu, Andrew Z., Sebastian, Luke, Brook, Byron, Bosco, Anna-Nicole, Borriello, Francesco, Ernst, Robert K., Barouch, Dan H., Dhe-Paganon, Sirano, Levy, Ofer, Frieman, Matthew B., Dowling, David J.
Published in Communications biology (06.08.2022)
Published in Communications biology (06.08.2022)
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Journal Article
Coronavirus interactions with the cellular autophagy machinery
Miller, Katelyn, McGrath, Marisa E., Hu, Zhiqiang, Ariannejad, Sohha, Weston, Stuart, Frieman, Matthew, Jackson, William T
Published in Autophagy (01.12.2020)
Published in Autophagy (01.12.2020)
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Journal Article
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis
McGrath, Marisa E., Xue, Yong, Dillen, Carly, Oldfield, Lauren, Assad-Garcia, N., Zaveri, Jayshree, Singh, Natasha, Baracco, Lauren, Taylor, Louis J., Vashee, Sanjay, Frieman, Matthew B.
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2022)
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Journal Article
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail
Dong, Jinhui, Zost, Seth J, Greaney, Allison J, Starr, Tyler N, Dingens, Adam S, Chen, Elaine C, Chen, Rita E, Case, James Brett, Sutton, Rachel E, Gilchuk, Pavlo, Rodriguez, Jessica, Armstrong, Erica, Gainza, Christopher, Nargi, Rachel S, Binshtein, Elad, Xie, Xuping, Zhang, Xianwen, Shi, Pei-Yong, Logue, James, Weston, Stuart, McGrath, Marisa E, Frieman, Matthew B, Brady, Tyler, Tuffy, Kevin M, Bright, Helen, Loo, Yueh-Ming, McTamney, Patrick M, Esser, Mark T, Carnahan, Robert H, Diamond, Michael S, Bloom, Jesse D, Crowe, Jr, James E
Published in Nature microbiology (01.10.2021)
Published in Nature microbiology (01.10.2021)
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An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice
Nanishi, Etsuro, Borriello, Francesco, O'Meara, Timothy R, McGrath, Marisa E, Saito, Yoshine, Haupt, Robert E, Seo, Hyuk-Soo, van Haren, Simon D, Cavazzoni, Cecilia B, Brook, Byron, Barman, Soumik, Chen, Jing, Diray-Arce, Joann, Doss-Gollin, Simon, De Leon, Maria, Prevost-Reilly, Alejandra, Chew, Katherine, Menon, Manisha, Song, Kijun, Xu, Andrew Z, Caradonna, Timothy M, Feldman, Jared, Hauser, Blake M, Schmidt, Aaron G, Sherman, Amy C, Baden, Lindsey R, Ernst, Robert K, Dillen, Carly, Weston, Stuart M, Johnson, Robert M, Hammond, Holly L, Mayer, Romana, Burke, Allen, Bottazzi, Maria E, Hotez, Peter J, Strych, Ulrich, Chang, Aiquan, Yu, Jingyou, Sage, Peter T, Barouch, Dan H, Dhe-Paganon, Sirano, Zanoni, Ivan, Ozonoff, Al, Frieman, Matthew B, Levy, Ofer, Dowling, David J
Published in Science translational medicine (26.01.2022)
Published in Science translational medicine (26.01.2022)
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Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
O'Meara, Timothy R, Nanishi, Etsuro, McGrath, Marisa E, Barman, Soumik, Dong, Danica, Dillen, Carly, Menon, Manisha, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Ernst, Robert K, Levy, Ofer, Frieman, Matthew B, Dowling, David J
Published in Journal of allergy and clinical immunology (01.11.2023)
Published in Journal of allergy and clinical immunology (01.11.2023)
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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
Borriello, Francesco, Poli, Valentina, Shrock, Ellen, Spreafico, Roberto, Liu, Xin, Pishesha, Novalia, Carpenet, Claire, Chou, Janet, Di Gioia, Marco, McGrath, Marisa E., Dillen, Carly A., Barrett, Nora A., Lacanfora, Lucrezia, Franco, Marcella E., Marongiu, Laura, Iwakura, Yoichiro, Pucci, Ferdinando, Kruppa, Michael D., Ma, Zuchao, Lowman, Douglas W., Ensley, Harry E., Nanishi, Etsuro, Saito, Yoshine, O’Meara, Timothy R., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Dowling, David J., Frieman, Matthew, Elledge, Stephen J., Levy, Ofer, Irvine, Darrell J., Ploegh, Hidde L., Williams, David L., Zanoni, Ivan
Published in Cell (17.02.2022)
Published in Cell (17.02.2022)
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The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses
Weston, Stuart, Baracco, Lauren, Keller, Chloe, Matthews, Krystal, McGrath, Marisa E., Logue, James, Liang, Janie, Dyall, Julie, Holbrook, Michael R., Hensley, Lisa E., Jahrling, Peter B., Yu, Wenbo, MacKerell, Alexander D., Frieman, Matthew B.
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.2020)
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Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination
Gorman, Matthew J., Patel, Nita, Guebre-Xabier, Mimi, Zhu, Alex L., Atyeo, Caroline, Pullen, Krista M., Loos, Carolin, Goez-Gazi, Yenny, Carrion, Ricardo, Tian, Jing-Hui, Yuan, Dansu, Bowman, Kathryn A., Zhou, Bin, Maciejewski, Sonia, McGrath, Marisa E., Logue, James, Frieman, Matthew B., Montefiori, David, Mann, Colin, Schendel, Sharon, Amanat, Fatima, Krammer, Florian, Saphire, Erica Ollmann, Lauffenburger, Douglas A., Greene, Ann M., Portnoff, Alyse D., Massare, Michael J., Ellingsworth, Larry, Glenn, Gregory, Smith, Gale, Alter, Galit
Published in Cell reports. Medicine (21.09.2021)
Published in Cell reports. Medicine (21.09.2021)
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Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice
Nanishi, Etsuro, Borriello, Francesco, Seo, Hyuk-Soo, O'Meara, Timothy R, McGrath, Marisa E, Saito, Yoshine, Chen, Jing, Diray-Arce, Joann, Song, Kijun, Xu, Andrew Z, Barman, Soumik, Menon, Manisha, Dong, Danica, Caradonna, Timothy M, Feldman, Jared, Hauser, Blake M, Schmidt, Aaron G, Baden, Lindsey R, Ernst, Robert K, Dillen, Carly, Yu, Jingyou, Chang, Aiquan, Hilgers, Luuk, Platenburg, Peter Paul, Dhe-Paganon, Sirano, Barouch, Dan H, Ozonoff, Al, Zanoni, Ivan, Frieman, Matthew B, Dowling, David J, Levy, Ofer
Published in npj vaccines (14.02.2023)
Published in npj vaccines (14.02.2023)
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Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice
Nanishi, Etsuro, Borriello, Francesco, Seo, Hyuk-Soo, O'Meara, Timothy R, McGrath, Marisa E, Saito, Yoshine, Chen, Jing, Diray-Arce, Joann, Song, Kijun, Xu, Andrew Z, Barman, Soumik, Menon, Manisha, Dong, Danica, Caradonna, Timothy M, Feldman, Jared, Hauser, Blake M, Schmidt, Aaron G, Baden, Lindsey R, Ernst, Robert K, Dillen, Carly, Yu, Jingyou, Chang, Aiquan, Hilgers, Luuk, Platenburg, Peter Paul, Dhe-Paganon, Sirano, Barouch, Dan H, Ozonoff, Al, Zanoni, Ivan, Frieman, Matthew B, Dowling, David J, Levy, Ofer
Published in npj vaccines (03.03.2023)
Published in npj vaccines (03.03.2023)
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Journal Article
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
O'meara, Timothy R, Nanishi, Etsuro, Mcgrath, Marisa E, Barman, Soumik, Dong, Danica, Dillen, Carly, Menon, Manisha, Hyuk-Soo Seo, Dhe-Paganon, Sirano, Ernst, Robert K, Levy, Ofer, Frieman, Matthew B, Dowling, David J
Published in bioRxiv (07.12.2022)
Published in bioRxiv (07.12.2022)
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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
Boras, Britton, Jones, Rhys M, Anson, Brandon J, Arenson, Dan, Aschenbrenner, Lisa, Bakowski, Malina A, Beutler, Nathan, Binder, Joseph, Chen, Emily, Eng, Heather, Hammond, Holly, Hammond, Jennifer, Haupt, Robert E, Hoffman, Robert, Kadar, Eugene P, Kania, Rob, Kimoto, Emi, Kirkpatrick, Melanie G, Lanyon, Lorraine, Lendy, Emma K, Lillis, Jonathan R, Logue, James, Luthra, Suman A, Ma, Chunlong, Mason, Stephen W, McGrath, Marisa E, Noell, Stephen, Obach, R Scott, O' Brien, Matthew N, O'Connor, Rebecca, Ogilvie, Kevin, Owen, Dafydd, Pettersson, Martin, Reese, Matthew R, Rogers, Thomas F, Rosales, Romel, Rossulek, Michelle I, Sathish, Jean G, Shirai, Norimitsu, Steppan, Claire, Ticehurst, Martyn, Updyke, Lawrence W, Weston, Stuart, Zhu, Yuao, White, Kris M, García-Sastre, Adolfo, Wang, Jun, Chatterjee, Arnab K, Mesecar, Andrew D, Frieman, Matthew B, Anderson, Annaliesa S, Allerton, Charlotte
Published in Nature communications (18.10.2021)
Published in Nature communications (18.10.2021)
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Journal Article
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis
McGrath, Marisa E, Xue, Yong, Dillen, Carly, Oldfield, Lauren, Assad-Garcia, N, Zaveri, Jayshree, Singh, Natasha, Baracco, Lauren, Taylor, Louis J, Vashee, Sanjay, Frieman, Matthew B
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2022)
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Journal Article
Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination
Gorman, Matthew J, Patel, Nita, Guebre-Xabier, Mimi, Zhu, Alex, Atyeo, Caroline, Pullen, Krista M, Loos, Carolin, Goez-Gazi, Yenny, Carrion, Jr, Ricardo, Tian, Jing-Hui, Yaun, Dansu, Bowman, Kathryn, Zhou, Bin, Maciejewski, Sonia, McGrath, Marisa E, Logue, James, Frieman, Matthew B, Montefiori, David, Mann, Colin, Schendel, Sharon, Amanat, Fatima, Krammer, Florian, Saphire, Erica Ollmann, Lauffenburger, Douglas, Greene, Ann M, Portnoff, Alyse D, Massare, Michael J, Ellingsworth, Larry, Glenn, Gregory, Smith, Gale, Alter, Galit
Published in bioRxiv (05.02.2021)
Published in bioRxiv (05.02.2021)
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