Identification and Optimization of Pyrrolo[3,2‑d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B
McGowan, David C, Herschke, Florence, Pauwels, Frederik, Stoops, Bart, Smyej, Ilham, Last, Stefaan, Pieters, Serge, Embrechts, Werner, Khamlichi, Mourad Daoubi, Thoné, Tine, Van Schoubroeck, Bertrand, Mostmans, Wendy, Wuyts, Debbie, Verstappen, Dorien, Scholliers, Annick, De Pooter, Dorien, Dhuyvetter, Deborah, Borghys, Herman, Tuefferd, Marianne, Arnoult, Eric, Hong, Jin, Fanning, Gregory, Bollekens, Jacques, Urmaliya, Vijay, Teisman, Ard, Horton, Helen, Jonckers, Tim H. M, Raboisson, Pierre
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
Get full text
Journal Article
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH
Vandyck, Koen, McGowan, David C., Luong, Xuan G., Stevens, Sarah K., Jekle, Andreas, Gupta, Kusum, Misner, Dinah L., Chanda, Sushmita, Serebryany, Vladimir, Welch, Michael, Hu, Haiyang, Lv, Zhidan, Williams, Caroline, Maskos, Klaus, Lammens, Alfred, Stoycheva, Antitsa D., Lin, Tse-I, Blatt, Lawrence M., Beigelman, Leonid N., Symons, Julian A., Raboisson, Pierre, Deval, Jerome
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
Get full text
Journal Article
Versatile Multicomponent Reaction Macrocycle Synthesis Using α‑Isocyano-ω-carboxylic Acids
Liao, George P, Abdelraheem, Eman M. M, Neochoritis, Constantinos G, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, McGowan, David C, Dömling, Alexander
Published in Organic letters (16.10.2015)
Published in Organic letters (16.10.2015)
Get full text
Journal Article
Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region
McGowan, David C, Balemans, Wendy, Embrechts, Werner, Motte, Magali, Keown, Jeremy R, Buyck, Christophe, Corbera, Jordi, Funes, Mario, Moreno, Laura, Cooymans, Ludwig, Tahri, Abdellah, Eymard, Julien, Stoops, Bart, Strijbos, Rudy, Van den Berg, Joke, Fodor, Ervin, Grimes, Jonathan M, Koul, Anil, Jonckers, Tim H. M, Raboisson, Pierre, Guillemont, Jérôme
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
Get full text
Journal Article
Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists
McGowan, David C., Herschke, Florence, Khamlichi, Mourad D., Rosauro, Mari Luz, Benedicto, Sara M. Pérez, Pauwels, Frederik, Stoops, Bart, Pande, Vineet, Scholliers, Annick, Van Schoubroeck, Bertrand, Mostmans, Wendy, Van Dijck, Kris, Thoné, Tine, Horton, Helen, Fanning, Gregory, Jonckers, Tim H.M., Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
Get full text
Journal Article
Synthesis and evaluation of novel HCV replication inhibitors
McGowan, David C., Khamlichi, Mourad D., De Groot, Alex, Pauwels, Frederik, Delouvroy, Frédéric, Van Emelen, Kristof, Simmen, Kenneth, Raboisson, Pierre
Published in Molecular diversity (01.05.2017)
Published in Molecular diversity (01.05.2017)
Get full text
Journal Article
Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Buchanan, John L, Buckner, William H, Cee, Victor J, Chai, Lilly, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Geuns-Meyer, Stephanie D, Gore, Anu, Gu, Yan, Henkle, Brad, Hodous, Brian L, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, Masse, Craig E, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian
Published in Journal of medicinal chemistry (21.09.2006)
Published in Journal of medicinal chemistry (21.09.2006)
Get full text
Journal Article
Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity
Martin, Matthew W, Newcomb, John, Nunes, Joseph J, McGowan, David C, Armistead, David M, Boucher, Christina, Buchanan, John L, Buckner, William, Chai, Lilly, Elbaum, Daniel, Epstein, Linda F, Faust, Theodore, Flynn, Shaun, Gallant, Paul, Gore, Anu, Gu, Yan, Hsieh, Faye, Huang, Xin, Lee, Josie H, Metz, Daniela, Middleton, Scot, Mohn, Deanna, Morgenstern, Kurt, Morrison, Michael J, Novak, Perry M, Oliveira-dos-Santos, Antonio, Powers, David, Rose, Paul, Schneider, Stephen, Sell, Stephanie, Tudor, Yanyan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zack, Debra, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian, Ghiron, Chiara, Amouzegh, Patricia, Ermann, Monika, Jenkins, James, Johnston, David, Napier, Spencer, Power, Eoin
Published in Journal of medicinal chemistry (10.08.2006)
Published in Journal of medicinal chemistry (10.08.2006)
Get full text
Journal Article
Discovery of 4-amino-5,6-biaryl-furo[2,3- d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR
DiMauro, Erin F., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., Boucher, Christina, Buchanan, John L., Buckner, William H., Cheng, Alan, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Marshall, Teresa L., Martin, Matthew W., McGowan, David C., Schneider, Stephen, Turci, Susan M., White, Ryan D., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Get full text
Journal Article
Discovery of novel 2,3-diarylfuro[2,3- b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties
Martin, Matthew W., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., McGowan, David C., White, Ryan D., Buchanan, John L., DiMauro, Erin F., Boucher, Christina, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Schneider, Stephen, Turci, Susan M., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Get full text
Journal Article
Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure–Activity Relationships, and Inhibition of in Vivo T Cell Activation
DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Chai, Lilly, Chaffee, Stuart C, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Gore, Anu, Gu, Yan, Henkle, Brad, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
Get full text
Journal Article
Erratum to “Discovery of novel 2,3-diarylfuro[2,3- b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties” [Bioorg. Med. Chem. Lett. 17 (2007) 2299–2304]
Martin, Matthew W., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., McGowan, David C., White, Ryan D., Buchanan, John L., DiMauro, Erin F., Boucher, Christina, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Schneider, Stephen, Turci, Susan M., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Get full text
Journal Article
Erratum to “Discovery of 4-amino-5,6-biaryl-furo[2,3- d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR” [Bioorg. Med. Chem. Lett. 17 (2007) 2305–2309]
DiMauro, Erin F., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., Boucher, Christina, Buchanan, John L., Buckner, William H., Cheng, Alan, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Marshall, Teresa L., Martin, Matthew W., McGowan, David C., Schneider, Stephen, Turci, Susan M., White, Ryan D., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Get full text
Journal Article
ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS
TEMPEST, Paul A, MASSE, Craig E, TOMLINSON, Susan Ann, ALBRECHT, Brian K, PARAS, Nick A, HODOUS, Brian L, WHITE, Ryan, THAMAN, Maya C, MCGOWAN, David C, PETTUS, Liping H, RZASA, Robert M, CHAFFEE, Stuart C, BUCKNER, William H, BUCHANAN, John L, HABGOOD, Gregory J, FALSEY, James Richard, DIMAURO, Erin F, BELLON, Steven, BEMIS, Jean E, CAO, Guo-giang, DEAK, Holly L, LIU, Gang, XU, Shimin, SMITH, Adrian Leonard, HERBERICH, Bradley J, CEE, Victor J, PATEL, Vinod F, ZHANG, Dawei, KIM, Joseph L, MARTIN, Matthew W, SHAM, Kelvin, GRACEFFA, Russell, TASKER, Andrew, REED, Anthony, HARMANGE, Jean-christophe, CHAKRABARTI, Partha P, DEMORIN, Frenel F, GEUNS-MEYER, Stephanie D, OLIVIERI, Philip R
Year of Publication 02.10.2019
Get full text
Year of Publication 02.10.2019
Patent
BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE
CHAFFEE, STUART, RUMFELT, SHANNON, DIMAURO, ERIN F, CHEN, NING, BEMIS, JEAN E, MARTIN, MATTHEW W, KUNZ, ROXANNE, MCGOWAN, DAVID C, HU, ESSA
Year of Publication 23.04.2014
Get full text
Year of Publication 23.04.2014
Patent
HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE
HODOUS, BRIAN L, CEE, VICTOR J, OLIVIERI, PHILIP R, ROMERO, KARINA, DIMAURO, ERIN F, REED, ANTHONY, ALBRECHT, BRIAN K, MARTIN, MATTHEW W, REDDY, GADE, MCGOWAN, DAVID C, CHAFFEE, STUART C
Year of Publication 24.04.2013
Get full text
Year of Publication 24.04.2013
Patent
BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE
DIMAURO ERIN F, HU ESSA, KUNZ ROXANNE, MARTIN MATTHEW W, MCGOWAN DAVID C, RUMFELT SHANNON, CHEN NING, BEMIS JEAN E, CHAFFEE STUART C
Year of Publication 16.09.2010
Get full text
Year of Publication 16.09.2010
Patent
Bis-aryl amide compounds and methods of use
DIMAURO ERIN F, HU ESSA, KUNZ ROXANNE, MARTIN MATTHEW W, MCGOWAN DAVID C, RUMFELT SHANNON, CHEN NING, BEMIS JEAN E, CHAFFEE STUART C
Year of Publication 13.07.2010
Get full text
Year of Publication 13.07.2010
Patent