PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases
Cushing, Timothy D, Metz, Daniela P, Whittington, Douglas A, McGee, Lawrence R
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
Get full text
Journal Article
Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development
Sun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David, Deignan, Jeffrey, Duquette, Jason, Eksterowicz, John, Fisher, Benjamin, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Gonzalez-Lopez De Turiso, Felix, Houze, Jonathan B, Huang, Xin, Jiang, Min, Jin, Lixia, Kayser, Frank, Liu, Jiwen (Jim), Lo, Mei-Chu, Long, Alexander M, Lucas, Brian, McGee, Lawrence R, McIntosh, Joel, Mihalic, Jeff, Oliner, Jonathan D, Osgood, Tao, Peterson, Matthew L, Roveto, Philip, Saiki, Anne Y, Shaffer, Paul, Toteva, Maria, Wang, Yingcai, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Yu, Ming, Zhao, Xiaoning, Zhou, Jing, Zhu, Jiang, Olson, Steven H, Medina, Julio C
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
Get full text
Journal Article
Practical Total Synthesis of the Anti-Influenza Drug GS-4104
Rohloff, John C, Kent, Kenneth M, Postich, Michael J, Becker, Mark W, Chapman, Harlan H, Kelly, Daphne E, Lew, Willard, Louie, Michael S, McGee, Lawrence R, Prisbe, Ernest J, Schultze, Lisa M, Yu, Richard H, Zhang, Lijun
Published in Journal of organic chemistry (26.06.1998)
Published in Journal of organic chemistry (26.06.1998)
Get full text
Journal Article
Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications
Nerurkar, Alok, Nguyen, Thomas, Wang, Sheldon, Bhatt, Ulhas, Li, Kevin, Li, Yihong, Ding, Pingyu, Seidl, Frederick J., Holan, Martin, Lee, John, Widjaja, Tien, Wei, Zhi-Liang, Sadlowski, Corinne, Sperandio, David, McGee, Lawrence R., Youngblood, Beth, Schwartz, Neil, Gehlert, Donald, Medina, Julio C.
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Get full text
Journal Article
Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)
Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Jahchan, Nadine, Zhu, Liusheng, Yan, Xuelei, Kawai, Hiroyuki, McGee, Lawrence R, Medina, Julio C, Huang, Tom, Chen, Chelsea, Zavorotinskaya, Tatiana, Sutimantanapi, Dena, Waszczuk, Joanna, Jackson, Erica, Huang, Elizabeth, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
Get full text
Journal Article
AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia
Li, Cong, Liu, Liqin, Liang, Lingming, Xia, Zhen, Li, Zhihong, Wang, Xianghong, McGee, Lawrence R, Newhall, Katie, Sinclair, Angus, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang
Published in Molecular cancer therapeutics (01.02.2015)
Published in Molecular cancer therapeutics (01.02.2015)
Get full text
Journal Article
Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
Get full text
Journal Article
An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553
Lucas, Brian S, Fisher, Benjamin, McGee, Lawrence R, Olson, Steven H, Medina, Julio C, Cheung, Eugene
Published in Journal of the American Chemical Society (01.08.2012)
Published in Journal of the American Chemical Society (01.08.2012)
Get full text
Journal Article
Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction
Gonzalez, Ana Z, Eksterowicz, John, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan B, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, McMinn, Dustin L, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
Get full text
Journal Article
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors
Shin, Youngsook, Suchomel, Julia, Cardozo, Mario, Duquette, Jason, He, Xiao, Henne, Kirk, Hu, Yi-Ling, Kelly, Ron C, McCarter, John, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, San Miguel, Tisha, Mohn, Deanna, Tran, Thuy, Vissinga, Christine, Wong, Simon, Wannberg, Sharon, Whittington, Douglas A, Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Xuxia, Cushing, Timothy D
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
Get full text
Journal Article
Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction
Rew, Yosup, Sun, Daqing, Yan, Xuelei, Beck, Hilary P, Canon, Jude, Chen, Ada, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Houze, Jonathan, Huang, Xin, Jiang, Min, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Saiki, Anne Y, Shaffer, Paul, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
Get full text
Journal Article
Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3
Li, Zhihong, Wang, Xianghong, Eksterowicz, John, Gribble, Michael W, Alba, Grace Q, Ayres, Merrill, Carlson, Timothy J, Chen, Ada, Chen, Xiaoqi, Cho, Robert, Connors, Richard V, DeGraffenreid, Michael, Deignan, Jeffrey T, Duquette, Jason, Fan, Pingchen, Fisher, Benjamin, Fu, Jiasheng, Huard, Justin N, Kaizerman, Jacob, Keegan, Kathleen S, Li, Cong, Li, Kexue, Li, Yunxiao, Liang, Lingming, Liu, Wen, Lively, Sarah E, Lo, Mei-Chu, Ma, Ji, McMinn, Dustin L, Mihalic, Jeffrey T, Modi, Kriti, Ngo, Rachel, Pattabiraman, Kanaka, Piper, Derek E, Queva, Christophe, Ragains, Mark L, Suchomel, Julia, Thibault, Steve, Walker, Nigel, Wang, Xiaodong, Wang, Zhulun, Wanska, Malgorzata, Wehn, Paul M, Weidner, Margaret F, Zhang, Alex J, Zhao, Xiaoning, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang, McGee, Lawrence R, Medina, Julio C
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
Get full text
Journal Article
INT131: A Selective Modulator of PPARγ
Motani, Alykhan, Wang, Zhulun, Weiszmann, Jennifer, McGee, Lawrence R., Lee, Gary, Liu, Qingxiang, Staunton, Jocelyn, Fang, Zexu, Fuentes, Helen, Lindstrom, Michelle, Liu, Jinsong, Biermann, Donna H.T., Jaen, Juan, Walker, Nigel P.C., Learned, R. Marc, Chen, Jin-Long, Li, Yang
Published in Journal of molecular biology (13.03.2009)
Published in Journal of molecular biology (13.03.2009)
Get full text
Journal Article
Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres
Gonzalez, Ana Z, Li, Zhihong, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan, Jin, Lixia, Li, Yihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Sun, Daqing, Medina, Julio C
Published in Journal of medicinal chemistry (10.04.2014)
Published in Journal of medicinal chemistry (10.04.2014)
Get full text
Journal Article
Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure–activity relationship, and co-crystal structures
Li, Kexue, McGee, Lawrence R., Fisher, Ben, Sudom, Athena, Liu, Jinsong, Rubenstein, Steven M., Anwer, Mohmed K., Cushing, Timothy D., Shin, Youngsook, Ayres, Merrill, Lee, Fei, Eksterowicz, John, Faulder, Paul, Waszkowycz, Bohdan, Plotnikova, Olga, Farrelly, Ellyn, Xiao, Shou-Hua, Chen, Guoqing, Wang, Zhulun
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Get full text
Journal Article
Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia
Keegan, Kathleen, Li, Cong, Li, Zhihong, Ma, Ji, Ragains, Mark, Coberly, Suzanne, Hollenback, David, Eksterowicz, John, Liang, Lingming, Weidner, Margaret, Huard, Justin, Wang, Xianghong, Alba, Grace, Orf, Jessica, Lo, Mei-Chu, Zhao, Sharon, Ngo, Rachel, Chen, Ada, Liu, Lily, Carlson, Timothy, Quéva, Christophe, McGee, Lawrence R, Medina, Julio, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang
Published in Molecular cancer therapeutics (01.04.2014)
Published in Molecular cancer therapeutics (01.04.2014)
Get full text
Journal Article
Synthesis and SAR study of potent and selective PI3Kδ inhibitors
Bui, Minna, Hao, Xiaolin, Shin, Youngsook, Cardozo, Mario, He, Xiao, Henne, Kirk, Suchomel, Julia, McCarter, John, McGee, Lawrence R., San Miguel, Tisha, Medina, Julio C., Mohn, Deanna, Tran, Thuy, Wannberg, Sharon, Wong, Jamie, Wong, Simon, Zalameda, Leeanne, Metz, Daniela, Cushing, Timothy D.
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Get full text
Journal Article
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430)
Gonzalez-Lopez de Turiso, Felix, Hao, Xiaolin, Shin, Youngsook, Bui, Minna, Campuzano, Iain D. G, Cardozo, Mario, Dunn, Michelle C, Duquette, Jason, Fisher, Benjamin, Foti, Robert S, Henne, Kirk, He, Xiao, Hu, Yi-Ling, Kelly, Ron C, Johnson, Michael G, Lucas, Brian S, McCarter, John, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, San Miguel, Tisha, Mohn, Deanna, Tran, Thuy, Vissinga, Christine, Wannberg, Sharon, Whittington, Douglas A, Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Xuxia, Cushing, Timothy D
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
Get full text
Journal Article
Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors
Gonzalez-Lopez de Turiso, Felix, Shin, Youngsook, Brown, Matthew, Cardozo, Mario, Chen, Yi, Fong, David, Hao, Xiaolin, He, Xiao, Henne, Kirk, Hu, Yi-Ling, Johnson, Michael G, Kohn, Todd, Lohman, Julia, McBride, Helen J, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, Miner, Kent, Mohn, Deanna, Pattaropong, Vatee, Seganish, Jennifer, Simard, Jillian L, Wannberg, Sharon, Whittington, Douglas A, Yu, Gang, Cushing, Timothy D
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
Get full text
Journal Article