Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
Finlay, M. Raymond V, Anderton, Mark, Ashton, Susan, Ballard, Peter, Bethel, Paul A, Box, Matthew R, Bradbury, Robert H, Brown, Simon J, Butterworth, Sam, Campbell, Andrew, Chorley, Christopher, Colclough, Nicola, Cross, Darren A. E, Currie, Gordon S, Grist, Matthew, Hassall, Lorraine, Hill, George B, James, Daniel, James, Michael, Kemmitt, Paul, Klinowska, Teresa, Lamont, Gillian, Lamont, Scott G, Martin, Nathaniel, McFarland, Heather L, Mellor, Martine J, Orme, Jonathon P, Perkins, David, Perkins, Paula, Richmond, Graham, Smith, Peter, Ward, Richard A, Waring, Michael J, Whittaker, David, Wells, Stuart, Wrigley, Gail L
Published in Journal of medicinal chemistry (23.10.2014)
Published in Journal of medicinal chemistry (23.10.2014)
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Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer
Bradbury, Robert H., Acton, David G., Broadbent, Nicola L., Brooks, A. Nigel, Carr, Gregory R., Hatter, Glenn, Hayter, Barry R., Hill, Kathryn J., Howe, Nicholas J., Jones, Rhys D.O., Jude, David, Lamont, Scott G., Loddick, Sarah A., McFarland, Heather L., Parveen, Zaieda, Rabow, Alfred A., Sharma-Singh, Gorkhn, Stratton, Natalie C., Thomason, Andrew G., Trueman, Dawn, Walker, Graeme E., Wells, Stuart L., Wilson, Joanne, Wood, J. Matthew
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
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Abstract 4744: Structure-based development of covalent inhibitors of the activating and T790M gatekeeper mutant forms of the epidermal growth factor receptor (EGFR) leading to the discovery of AZD9291
Ward, Richard A., Ashton, Susan, Anderton, Mark, Ballard, Pete G., Bradbury, Rob H., Butterworth, Sam, Colclough, Nicola, Cross, Darren A E, Finlay, M Ray V., McFarland, Heather L., Mellor, Martine, Waring, Mike J.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract B94: Discovery of and first disclosure of the clinical candidate AZD9291, a potent and selective third-generation EGFR inhibitor of both activating and T790M resistant mutations that spares the wild type form of the receptor
Finlay, M. Raymond V., Anderton, Mark, Ashton, Susan, Ballard, Peter G., Bradbury, Rob H., Butterworth, Sam, Chuaqui, Claudio E., Colclough, Nicola, Cross, Darren A. E., McFarland, Heather L., Mellor, Martine J., Ward, Richard A., Waring, Mike J.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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