QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency
Sun, Guohui, Bai, Peiying, Fan, Tengjiao, Zhao, Lijiao, Zhong, Rugang, McElhinney, R. Stanley, McMurry, T. Brian H, Donnelly, Dorothy J, McCormick, Joan E, Kelly, Jane, Margison, Geoffrey P
Published in Pharmaceutics (01.08.2023)
Published in Pharmaceutics (01.08.2023)
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Dual repair modulation reverses Temozolomide resistance in vitro
Barvaux, Vincent A, Ranson, Malcolm, Brown, Robert, McElhinney, R Stanley, McMurry, T Brian H, Margison, Geoffrey P
Published in Molecular cancer therapeutics (01.02.2004)
Published in Molecular cancer therapeutics (01.02.2004)
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Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT)
Shibata, Takayuki, Glynn, Nicola, McMurry, T. Brian H., McElhinney, R. Stanley, Margison, Geoffrey P., Williams, David M.
Published in Nucleic acids research (01.01.2006)
Published in Nucleic acids research (01.01.2006)
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Lomeguatrib, a Potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors
Ranson, Malcolm, Middleton, Mark R, Bridgewater, John, Lee, Siow Ming, Dawson, Martin, Jowle, Debra, Halbert, Gavin, Waller, Sue, McGrath, Helen, Gumbrell, Lindsey, McElhinney, R Stanley, Donnelly, Dorothy, McMurry, T Brian H, Margison, Geoffrey P
Published in Clinical cancer research (01.03.2006)
Published in Clinical cancer research (01.03.2006)
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Journal Article
Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase
Barvaux, Vincent A, Lorigan, Paul, Ranson, Malcolm, Gillum, Amanda M, McElhinney, R Stanley, McMurry, T Brian H, Margison, Geoffrey P
Published in Molecular cancer therapeutics (01.10.2004)
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Published in Molecular cancer therapeutics (01.10.2004)
Journal Article
Intermediates in the Ing-Manske reaction
Curley, O. M. Sinead, McCormick, Joan E., McElhinney, R. Stanley, McMurry, T. Brian H.
Published in ARKIVOC (17.05.2003)
Published in ARKIVOC (17.05.2003)
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Effect of O6‐(4‐bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model
Middleton, Mark R., Thatcher, Nicholas, McMurry, T. Brian H., McElhinney, R. Stanley, Donnelly, Dorothy J., Margison, Geoffrey P.
Published in International journal of cancer (10.08.2002)
Published in International journal of cancer (10.08.2002)
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Journal Article
Lomeguatrib, a Potent Inhibitor of O 6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors
Ranson, Malcolm, Middleton, Mark R., Bridgewater, John, Lee, Siow Ming, Dawson, Martin, Jowle, Debra, Halbert, Gavin, Waller, Sue, McGrath, Helen, Gumbrell, Lindsey, McElhinney, R. Stanley, Donnelly, Dorothy, McMurry, T. Brian H., Margison, Geoffrey P.
Published in Clinical cancer research (01.03.2006)
Published in Clinical cancer research (01.03.2006)
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O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts
Middleton, M R, Kelly, J, Thatcher, N, Donnelly, D J, McElhinney, R S, McMurry, T B, McCormick, J E, Margison, G P
Published in International journal of cancer (15.01.2000)
Published in International journal of cancer (15.01.2000)
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Journal Article
Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O 6-alkylguanine-DNA alkyltransferase
Barvaux, Vincent A., Lorigan, Paul, Ranson, Malcolm, Gillum, Amanda M., McElhinney, R. Stanley, McMurry, T. Brian H., Margison, Geoffrey P.
Published in Molecular cancer therapeutics (01.10.2004)
Published in Molecular cancer therapeutics (01.10.2004)
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Journal Article
Effect of O 6 ‐(4‐bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model
Middleton, Mark R., Thatcher, Nicholas, McMurry, T. Brian H., McElhinney, R. Stanley, Donnelly, Dorothy J., Margison, Geoffrey P.
Published in International journal of cancer (10.08.2002)
Published in International journal of cancer (10.08.2002)
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Journal Article
N,N '-transphthaloylation in a monoprotected diamine
McCormick, JE, McElhinney, RS, McMurry, TBH, O'Brien, JE
Published in Synthesis (Stuttgart) (17.03.2006)
Published in Synthesis (Stuttgart) (17.03.2006)
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Inactivation of O 6-Alkylguanine-DNA Alkyltransferase. 1. Novel O 6-(Hetarylmethyl)guanines Having Basic Rings in the Side Chain
McElhinney, R. Stanley, Donnelly, Dorothy J, McCormick, Joan E, Kelly, Jane, Watson, Amanda J, Rafferty, Joseph A, Elder, Rhoderick H, Middleton, Mark R, Willington, Mark A, McMurry, T. Brian H, Margison, Geoffrey P
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Synthesis of Potential Anticancer Agents. V. Azetidines1,2
VAUGHAN, WYMAN R, KLONOWSKI, ROBERT S, McELHINNEY, R. STANLEY, MILLWARD, BRIAN B
Published in Journal of organic chemistry (01.01.1961)
Published in Journal of organic chemistry (01.01.1961)
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O6‐(4‐bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts
Middleton, Mark R., Kelly, Jane, Thatcher, Nicholas, Donnelly, Dorothy J., McElhinney, R. Stanley, McMurry, T. Brian H., McCormick, Joan E., Margison, Geoffrey P.
Published in International journal of cancer (15.01.2000)
Published in International journal of cancer (15.01.2000)
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Journal Article
O6-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts
MIDDLETON, M. R, KELLY, J, THATCHER, N, DONNELLY, D. J, MCELHINNEY, R. S, BRIAN, T, MCMURRY, H, MCCORMICK, J. E, MARGISON, G. P
Published in International journal of cancer (15.01.2000)
Published in International journal of cancer (15.01.2000)
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Nucleoside Analogs. 14. The Synthesis and Antitumor Activity in Mice of Molecular Combinations of 5-Fluorouracil and N-(2-Chloroethyl)-N-nitrosourea Moieties Separated by a Three-Carbon Chain
McElhinney, R. Stanley, McCormick, Joan E, Bibby, Mike C, Double, John A, Radacic, Marco, Dumont, Patrick
Published in Journal of medicinal chemistry (29.03.1996)
Published in Journal of medicinal chemistry (29.03.1996)
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