Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924
Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.
Published in Cancer cell (20.03.2012)
Published in Cancer cell (20.03.2012)
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Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study
Italiano, Antoine, Soria, Jean-Charles, Toulmonde, Maud, Michot, Jean-Marie, Lucchesi, Carlo, Varga, Andrea, Coindre, Jean-Michel, Blakemore, Stephen J, Clawson, Alicia, Suttle, Benjamin, McDonald, Alice A, Woodruff, Mark, Ribich, Scott, Hedrick, Eric, Keilhack, Heike, Thomson, Blythe, Owa, Takashi, Copeland, Robert A, Ho, Peter T C, Ribrag, Vincent
Published in The lancet oncology (01.05.2018)
Published in The lancet oncology (01.05.2018)
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Journal Article
Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B‑Cell Lymphoma
Weiss, Matthew M., Zheng, Xiaozhang, Ji, Nan, Browne, Chris M., Campbell, Veronica, Chen, Dapeng, Enerson, Brad, Fei, Xue, Huang, Xin, Klaus, Christine R., Li, Haoran, Mayo, Michele, McDonald, Alice A., Paul, Atanu, Rong, Haojing, Sharma, Kirti, Shi, Yatao, Slavin, Anthony, Walther, Dirk M., Yuan, Karen, Zhang, Yi, Zhu, Xiao, Kelleher, Joe, Walker, Duncan, Mainolfi, Nello
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Journal Article
Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases
Zheng, Xiaozhang, Ji, Nan, Campbell, Veronica, Slavin, Anthony, Zhu, Xiao, Chen, Dapeng, Rong, Haojing, Enerson, Brad, Mayo, Michele, Sharma, Kirti, Browne, Chris M, Klaus, Christine R, Li, Haoran, Massa, Ginny, McDonald, Alice A, Shi, Yatao, Sintchak, Mike, Skouras, Stephanie, Walther, Dirk M, Yuan, Karen, Zhang, Yi, Kelleher, Joe, Liu, Guang, Luo, Xinbo, Mainolfi, Nello, Weiss, Matthew M
Published in Journal of medicinal chemistry (16.08.2024)
Published in Journal of medicinal chemistry (16.08.2024)
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Abstract LB118: Mechanisms underlying synergistic activity in MYD88MTDLBCL of KT-413, a targeted degrader of IRAK4 and IMiD substrate
Klaus, Christine R., Rusin, Scott F., Sharma, Kirti, Bhaduri, Samyabrata, Weiss, Matthew M., McDonald, Alice A., Mayo, Michele F., Walker, Duncan, Karnik, Rahul
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Discovery of Candidate Predictors of Response to Tazemetostat in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma Using NGS Technology on ctDNA Samples Collected Pre-Treatment
Daigle, Scott, McDonald, Alice A., Morschhauser, Franck, Salles, Gilles, Ribrag, Vincent, McKay, Pamela, Tilly, Herve, Schmitt, Anna, Gerecitano, John, Fruchart, Christophe, Johnson, Peter, Radford, John, Dickinson, Michael J., Herbaux, Charles, Opat, Stephen, Jurczak, Wojciech, Cartron, Guillaume, Lamy, Thierry, Zinzani, Pier Luigi, Assouline, Sarit, Morin, Ryan D., Wu, Helen, Sausen, Mark, Clawson, Alicia, Ho, Peter, Miao, Harry, Blakemore, Stephen
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Response to the EZH2 Inhibitor Tazemetostat Is Independent of Cell of Origin Determined Via Hans Imunohistochemistry or Nanostring Lymphoma Subtyping Test in EZH2 Wild-Type DLBCL Patients
McDonald, Alice A., Morschhauser, Franck, Ribrag, Vincent, McKay, Pamela, Salles, Gilles, Tilly, Herve, Schmitt, Anna, Gerecitano, John, Dickinson, Michael J., Assouline, Sarit, Haioun, Corinne, Gribben, John G., Zinzani, Pier Luigi, Wu, Helen, Kussick, Steven, Storhoff, James, Larus, John, Clawson, Alicia, Grayson, Adlai, Daigle, Scott, Ho, Peter, Miao, Harry, Blakemore, Stephen
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Abstract B6: Advanced image analysis of H3K27 trimethylation in skin from subjects dosed with the EZH2 inhibitor tazemetostat
McDonald, Alice A., Kuznetsov, Galina, Kumar, Namita, Weaver, Amy, Do, Trevor, Dzubay, Jeff, Keilhack, Heike, waters, Nigel, Rioux, Nathalie, Blakemore, Stephen J.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract A38: Development and implementation of immunohistochemistry (IHC)-based pharmacodynamic (PD) biomarkers demonstrate NAE pathway inhibition in MLN4924 solid tumor clinical trials
McDonald, Alice A., Burke, Kristine, Thomas, Michael, Berger, Alison, Smith, Peter G., Tirrell, Stephen, Blakemore, Stephen J., Mulligan, Geogre, Pickard, Michael D., Fleming, Mark D., Kauh, John S., Sarantopoulos, John, Dezube, Bruce J., Stringer, Bradley
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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