Novel drug combination nanoparticles exhibit enhanced plasma exposure and dose-responsive effects on eliminating breast cancer lung metastasis
Mu, Qingxin, Yu, Jesse, Griffin, James I, Wu, Yan, Zhu, Linxi, McConnachie, Lisa A, Ho, Rodney J Y
Published in PloS one (06.03.2020)
Published in PloS one (06.03.2020)
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Three HIV Drugs, Atazanavir, Ritonavir, and Tenofovir, Coformulated in Drug-Combination Nanoparticles Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates
Perazzolo, Simone, Shireman, Laura M., Koehn, Josefin, McConnachie, Lisa A., Kraft, John C., Shen, Danny D., Ho, Rodney J.Y.
Published in Journal of pharmaceutical sciences (01.12.2018)
Published in Journal of pharmaceutical sciences (01.12.2018)
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Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection
McConnachie, Lisa A., Kinman, Loren M., Koehn, Josefin, Kraft, John C., Lane, Sarah, Lee, Wonsok, Collier, Ann C., Ho, Rodney J.Y.
Published in Journal of pharmaceutical sciences (01.07.2018)
Published in Journal of pharmaceutical sciences (01.07.2018)
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Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation
Kraft, John C., McConnachie, Lisa A., Koehn, Josefin, Kinman, Loren, Sun, Jianguo, Collier, Ann C., Collins, Carol, Shen, Danny D., Ho, Rodney J.Y.
Published in Journal of controlled release (10.04.2018)
Published in Journal of controlled release (10.04.2018)
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Novel Long-Acting Drug Combination Nanoparticles Composed of Gemcitabine and Paclitaxel Enhance Localization of Both Drugs in Metastatic Breast Cancer Nodules
Yu, Jesse, Mu, Qingxin, Perazzolo, Simone, Griffin, James I, Zhu, Linxi, McConnachie, Lisa A, Shen, Danny D, Ho, Rodney JY
Published in Pharmaceutical research (01.10.2020)
Published in Pharmaceutical research (01.10.2020)
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Journal Article
Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma
Kraft, John C, McConnachie, Lisa A, Koehn, Josefin, Kinman, Loren, Collins, Carol, Shen, Danny D, Collier, Ann C, Ho, Rodney J.Y
Published in AIDS (London) (27.03.2017)
Published in AIDS (London) (27.03.2017)
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Extended cell and plasma drug levels after one dose of a three-in-one nanosuspension containing lopinavir, efavirenz, and tenofovir in nonhuman primates
Koehn, Josefin, Iwamoto, Jennifer F, Kraft, John C, McConnachie, Lisa A, Collier, Ann C, Ho, Rodney J.Y
Published in AIDS (London) (13.11.2018)
Published in AIDS (London) (13.11.2018)
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Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101
Perazzolo, Simone, Shireman, Laura M., McConnachie, Lisa A., Koehn, Josefin, Kinman, Loren, Lee, Wonsok, Lane, Sarah, Collier, Ann C., Shen, Danny D., Ho, Rodney J.Y.
Published in Journal of pharmaceutical sciences (01.05.2020)
Published in Journal of pharmaceutical sciences (01.05.2020)
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Journal Article
Translation of combination nanodrugs into nanomedicines: lessons learned and future outlook
Mu, Qingxin, Yu, Jesse, McConnachie, Lisa A., Kraft, John C., Gao, Yu, Gulati, Gaurav K., Ho, Rodney J. Y.
Published in Journal of drug targeting (28.05.2018)
Published in Journal of drug targeting (28.05.2018)
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Lack of Maternal Glutamate Cysteine Ligase Modifier Subunit (Gclm) Decreases Oocyte Glutathione Concentrations and Disrupts Preimplantation Development in Mice
Nakamura, Brooke N, Fielder, Thomas J, Hoang, Yvonne D, Lim, Jinhwan, McConnachie, Lisa A, Kavanagh, Terrance J, Luderer, Ulrike
Published in Endocrinology (Philadelphia) (01.07.2011)
Published in Endocrinology (Philadelphia) (01.07.2011)
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The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice
McConnachie, Lisa A, Botta, Dianne, White, Collin C, Weldy, Chad S, Wilkerson, Hui-Wen, Yu, Jianbo, Dills, Russell, Yu, Xiaozhong, Griffith, William C, Faustman, Elaine M, Farin, Federico M, Gill, Sean E, Parks, William C, Hu, Xiaoge, Gao, Xiaohu, Eaton, David L, Kavanagh, Terrance J
Published in PloS one (27.05.2013)
Published in PloS one (27.05.2013)
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Glutamate Cysteine Ligase Modifier Subunit Deficiency and Gender as Determinants of Acetaminophen-Induced Hepatotoxicity in Mice
McConnachie, Lisa A., Mohar, Isaac, Hudson, Francesca N., Ware, Carol B., Ladiges, Warren C., Fernandez, Carolina, Chatterton-Kirchmeier, Sam, White, Collin C., Pierce, Robert H., Kavanagh, Terrance J.
Published in Toxicological sciences (01.10.2007)
Published in Toxicological sciences (01.10.2007)
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New characterization of dihydroergotamine receptor pharmacology in the context of migraine: utilization of a β-arrestin recruitment assay
McConnachie, Lisa, Goadsby, Peter J, Vann, Robert E, Ray, Sutapa, Shrewsbury, Stephen B, Aurora, Sheena K
Published in Frontiers in neurology (2023)
Published in Frontiers in neurology (2023)
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Journal Article
Susceptibility to quantum dot induced lung inflammation differs widely among the Collaborative Cross founder mouse strains
Scoville, David K., White, Collin C., Botta, Dianne, McConnachie, Lisa A., Zadworny, Megan E., Schmuck, Stefanie C., Hu, Xiaoge, Gao, Xiaohu, Yu, Jianbo, Dills, Russell L., Sheppard, Lianne, Delaney, Martha A., Griffith, William C., Beyer, Richard P., Zangar, Richard C., Pounds, Joel G., Faustman, Elaine M., Kavanagh, Terrance J.
Published in Toxicology and applied pharmacology (01.12.2015)
Published in Toxicology and applied pharmacology (01.12.2015)
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Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice
Nakamura, Brooke N, Mohar, Isaac, Lawson, Gregory W, Cortés, Mabel M, Hoang, Yvonne D, Ortiz, Laura, Patel, Reshma, Rau, Bogdan A, McConnachie, Lisa A, Kavanagh, Terrance J, Luderer, Ulrike
Published in Toxicological sciences (01.03.2012)
Published in Toxicological sciences (01.03.2012)
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Journal Article
Multicenter Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses
Beyer, Richard P., Fry, Rebecca C., Lasarev, Michael R., McConnachie, Lisa A., Meira, Lisiane B., Palmer, Valerie S., Powell, Christine L., Ross, Pamela K., Bammler, Theo K., Bradford, Blair U., Cranson, Alex B., Cunningham, Michael L., Fannin, Rickie D., Higgins, Gregory M., Hurban, Patrick, Kayton, Robert J., Kerr, Kathleen F., Kosyk, Oksana, Lobenhofer, Edward K., Sieber, Stella O., Vliet, Portia A., Weis, Brenda K., Wolfinger, Russel, Woods, Courtney G., Freedman, Jonathan H., Linney, Elwood, Kaufmann, William K., Kavanagh, Terrance J., Paules, Richard S., Rusyn, Ivan, Samson, Leona D., Spencer, Peter S., Suk, William, Tennant, Raymond J., Zarbl, Helmut
Published in Toxicological sciences (01.09.2007)
Published in Toxicological sciences (01.09.2007)
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Journal Article
Heme oxygenase expression as a biomarker of exposure to amphiphilic polymer-coated CdSe/ZnS quantum dots
McConnachie, Lisa A., White, Collin C., Botta, Dianne, Zadworny, Megan E., Cox, David P., Beyer, Richard P., Hu, Xiaoge, Eaton, David L., Gao, Xiaohu, Kavanagh, Terrance J.
Published in Nanotoxicology (01.03.2013)
Published in Nanotoxicology (01.03.2013)
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Journal Article
Modulating GSH Synthesis Using Glutamate Cysteine Ligase Transgenic and Gene-Targeted Mice
Botta, Dianne, White, Collin C., Vliet-Gregg, Portia, Mohar, Isaac, Shi, Shengli, McGrath, Monica B., McConnachie, Lisa A., Kavanagh, Terrance J.
Published in Drug metabolism reviews (01.01.2008)
Published in Drug metabolism reviews (01.01.2008)
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Conference Proceeding
ONLY TRUNCATED, NOT COMPLETE CYTOCHROME P450 2D6 RNA TRANSCRIPT AND NO DETECTABLE ENZYME ACTIVITY ARE EXPRESSED IN HUMAN LYMPHOCYTES
MCCONNACHIE, Lisa A, PHILLIPS, Brian, BAJPAI, Manoj, SHEN, Danny D, HO, Rodney J. Y
Published in Drug metabolism and disposition (01.09.2003)
Published in Drug metabolism and disposition (01.09.2003)
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Journal Article
Controlled Solvent Removal from Antiviral Drugs and Excipients in Solution Enables the Formation of Novel Combination Multi-Drug-Motifs in Pharmaceutical Powders Composed of Lopinavir, Ritonavir and Tenofovir
Yu, Jesse, Yu, Danni, Lane, Sarah, McConnachie, Lisa, Ho, Rodney J.Y.
Published in Journal of pharmaceutical sciences (01.11.2020)
Published in Journal of pharmaceutical sciences (01.11.2020)
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