Pharmacokinetics of selonsertib, GS-9674, and/or GS-0976 in combination in healthy subjects
Nelson, C.H, Kirby, B.J, Lu, N, McColgan, B, Djedjos, C.S, Myers, R.P, Cuvin, J, Qin, A, Mathias, A
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Efficacy and safety of simtuzumab for the treatment of primary sclerosing cholangitis: results of a phase 2b, dose-ranging, randomized, placebo-controlled trial
Muir, A, Goodman, Z, Levy, C, Janssen, H, Montano-Loza, A, Bowlus, C, Ding, D, Jia, C, McColgan, B, Myers, R, Subramanian, M, McHutchison, J, Manns, M, Chapman, R, Afdhal, N, Eksteen, B
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Prospective validation of the Enhanced Liver Fibrosis test for the prediction of disease progression in a randomized trial of patients with primary sclerosing cholangitis
Bowlus, C, Patel, K, Hirschfield, G, Guha, I, Chapman, R, Chazouilleres, O, Ding, D, Jia, C, Mccolgan, B, Myers, R, Subramanian, M, McHutchison, J, Muir, A, Goodman, Z, Rosenberg, W, Levy, C
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Impact of modest weight reduction on liver histology, portal pressure, and clinical events in patients with compensated cirrhosis due to nonalcoholic steatohepatitis
Bosch, J, Harrison, S, Ratziu, V, Shiffman, M, Diehl, A, Caldwell, S, Rockey, D, Ghalib, R, Thuluvath, P, Abdelmalek, M, Aguilar, R, Jia, C, Mccolgan, B, Myers, R, Subramanian, M, McHutchison, J, Goodman, Z, Afdhal, N, Sanyal, A
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Journal Article
Acetyl-CoA carboxylase (ACC) inhibitor GS-0976 leads to suppression of hepatic de novo lipogenesis and significant improvements in MRI-PDFF, MRE, and markers of fibrosis after 12 weeks of therapy in patients with NASH
Lawitz, E.J, Poordad, F, Coste, A, Loo, N, Djedjos, C.S, McColgan, B, Jia, C, Xu, R, Myers, R.P, Subramanian, G.M, McHutchison, J.G, Middleton, M.S, Sirlin, C, Nyangau, E, Fitch, M, Li, K, Hellerstein, M
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Common variation near glial-derived neurotrophic factor is associated with progression of hepatic collagen content in a genome-wide association study of liver fibrosis phenotypes in patients with primary sclerosing cholangitis
Shea, P, Hirschfield, G, Shiffman, M, McColgan, B, Goodman, Z, Myers, R, Subramanian, M, Eksteen, B, Janssen, H, Bowlus, C, Muir, A, Montano-Loza, A, McHutchison, J, Manns, M, Chapman, R, Kleinstein, S, Levy, C, Goldstein, D
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Journal Article
Changes in fibrosis, but not the NAFLD Activity Score (NAS), are associated with disease progression in patients with nonalcoholic steatohepatitis (NASH) and advanced fibrosis
Sanyal, A, Harrison, S, Ratziu, V, Abdelmalek, M, Diehl, A, Caldwell, S, Shiffman, M, Aguilar, R, Jia, C, McColgan, B, Myers, R, Subramanian, M, McHutchison, J, Muir, A, Afdhal, N, Bosch, J, Goodman, Z
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Journal Article
Serum fibroblast growth factor 19, 7α-Hydroxy-4-Cholesten-3-one, and bile acids and their associations with clinical characteristics in primary sclerosing cholangitis
Levy, C, Shiffman, M, Caldwell, S, Luketic, V, Invernizzi, P, Minuk, G, Pockros, P, Goodman, Z, Ding, D, Billin, A, Mccolgan, B, Djedjos, S, Myers, R, Subramanian, M, Eksteen, B, Bowlus, C, Muir, A
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Journal Article
Impact of weight reduction on serum markers and liver histology including progression to cirrhosis in patients with nonalcoholic steatohepatitis (NASH) and bridging fibrosis
Ratziu, V, Sanyal, A, Torres, D, Hinrichsen, H, Serfaty, L, Bambha, K, Jayakumar, S, Goodman, Z, Abdelmalek, M, Aguilar, R, Jia, C, Mccolgan, B, Myers, R, Subramanian, M, McHutchison, J, Afdhal, N, Harrison, S
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Journal Article
Prospective validation of serum alkaline phosphatase for the prediction of disease progression in a randomized trial of patients with primary sclerosing cholangitis
Levy, C, Eksteen, B, Shiffman, M, Janssen, H, Montano-Loza, A, Ding, D, Jia, C, Mccolgan, B, Myers, R, Subramanian, M, McHutchison, J, Chapman, R, Manns, M, Goodman, Z, Bowlus, C, Muir, A, Hirschfield, G
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Journal Article
Validation of a quantitative imaging assessment biomarker metric for MRI-estimated proton density fat fraction in a large multi-center clinical trial
Middleton, M., Henderson, W., Cui, J., Mamidipalli, A., Myers, R., Djedjos, S., Yeaton, C., Mccolgan, B., Loomba, R., Sirlin, C.
Published in Journal of hepatology (01.04.2018)
Published in Journal of hepatology (01.04.2018)
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Journal Article
FRI-461 - Validation of a quantitative imaging assessment biomarker metric for MRI-estimated proton density fat fraction in a large multi-center clinical trial
Middleton, M., Henderson, W., Cui, J., Mamidipalli, A., Myers, R., Djedjos, S., Yeaton, C., Mccolgan, B., Loomba, R., Sirlin, C.
Published in Journal of hepatology (01.04.2018)
Published in Journal of hepatology (01.04.2018)
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Journal Article
SAT-524 - The conundrum of cryptogenic liver disease with advanced fibrosis: Poor clinical outcomes without treatment options
Younossi, Z., Stepanova, M., Harrison, S., Sanyal, A., Ratziu, V., Mccolgan, B., Myers, R., Afdhal, N., Abdelmalek, M., Goodman, Z.
Published in Journal of hepatology (01.04.2018)
Published in Journal of hepatology (01.04.2018)
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Journal Article
The conundrum of cryptogenic liver disease with advanced fibrosis: Poor clinical outcomes without treatment options
Younossi, Z., Stepanova, M., Harrison, S., Sanyal, A., Ratziu, V., Mccolgan, B., Myers, R., Afdhal, N., Abdelmalek, M., Goodman, Z.
Published in Journal of hepatology (01.04.2018)
Published in Journal of hepatology (01.04.2018)
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Journal Article
Hypothyroidism and aging: the Rosses' survey
Bonar, B D, McColgan, B, Smith, D F, Darke, C, Guttridge, M G, Williams, H, Smyth, P P
Published in Thyroid (New York, N.Y.) (01.09.2000)
Published in Thyroid (New York, N.Y.) (01.09.2000)
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FRI-488 - Characterization of changes in lipoprotein profiles of patients with nonalcoholic steatohepatitis treated with the acetyl-CoA carboxylase inhibitor GS-0976
Mantry, P., Kayali, Z., Noureddin, M., Ruane, P., Mccolgan, B., Tarrant, J., Wang, L., Nguyen, T., Harting, E., Djedjos, S., Ray, A., Myers, R., Lai, M., Charlton, M., Lawitz, E., Harrison, S., Loomba, R.
Published in Journal of hepatology (01.04.2018)
Published in Journal of hepatology (01.04.2018)
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Journal Article
THU-456 - Whole exome sequencing identifies rare nonsense mutations enriched among patients with advanced fibrosis due to nonalcoholic steatohepatitis
Shea, P.R., Sanyal, A., Harrison, S., Ratziu, V., Loomba, R., Caldwell, S., Kleinstein, S., Mccolgan, B., Subramanian, M., Mchutchison, J.G., Myers, R., Goodman, Z., Abdelmalek, M., Bosch, J., Afdhal, N., Goldstein, D.
Published in Journal of hepatology (01.04.2018)
Published in Journal of hepatology (01.04.2018)
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