A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation
Wurz, Ryan P, Dellamaggiore, Ken, Dou, Hannah, Javier, Noelle, Lo, Mei-Chu, McCarter, John D, Mohl, Dane, Sastri, Christine, Lipford, J. Russell, Cee, Victor J
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
Get full text
Journal Article
Systematic Study of the Glutathione Reactivity of N‑Phenylacrylamides: 2. Effects of Acrylamide Substitution
Birkholz, Adam, Kopecky, David J, Volak, Laurie P, Bartberger, Michael D, Chen, Yuping, Tegley, Christopher M, Arvedson, Tara, McCarter, John D, Fotsch, Christopher, Cee, Victor J
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
Get full text
Journal Article
Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures
Du, Zhimei, Treiber, David, McCarter, John D., Fomina-Yadlin, Dina, Saleem, Ramsey A., McCoy, Rebecca E., Zhang, Yuling, Tharmalingam, Tharmala, Leith, Matthew, Follstad, Brian D., Dell, Brad, Grisim, Brent, Zupke, Craig, Heath, Carole, Morris, Arvia E., Reddy, Pranhitha
Published in Biotechnology and bioengineering (01.01.2015)
Published in Biotechnology and bioengineering (01.01.2015)
Get full text
Journal Article
Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
Meininger, David, Zalameda, Leeanne, Liu, Yichin, Stepan, Lara P., Borges, Luis, McCarter, John D., Sutherland, Claire L.
Published in Biochimica et biophysica acta (01.12.2011)
Published in Biochimica et biophysica acta (01.12.2011)
Get full text
Journal Article
Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors
D’Angelo, Noel D, Kim, Tae-Seong, Andrews, Kristin, Booker, Shon K, Caenepeel, Sean, Chen, Kui, D’Amico, Derin, Freeman, Dan, Jiang, Jian, Liu, Longbin, McCarter, John D, San Miguel, Tisha, Mullady, Erin L, Schrag, Michael, Subramanian, Raju, Tang, Jin, Wahl, Robert C, Wang, Ling, Whittington, Douglas A, Wu, Tian, Xi, Ning, Xu, Yang, Yakowec, Peter, Yang, Kevin, Zalameda, Leeanne P, Zhang, Nancy, Hughes, Paul, Norman, Mark H
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
Get full text
Journal Article
Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases
Smith, Adrian L, D’Angelo, Noel D, Bo, Yunxin Y, Booker, Shon K, Cee, Victor J, Herberich, Brad, Hong, Fang-Tsao, Jackson, Claire L. M, Lanman, Brian A, Liu, Longbin, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Tadesse, Seifu, Tamayo, Nuria A, Wurz, Ryan P, Yang, Kevin, Andrews, Kristin L, Whittington, Douglas A, McCarter, John D, Miguel, Tisha San, Zalameda, Leeanne, Jiang, Jian, Subramanian, Raju, Mullady, Erin L, Caenepeel, Sean, Freeman, Daniel J, Wang, Ling, Zhang, Nancy, Wu, Tian, Hughes, Paul E, Norman, Mark H
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
Get full text
Journal Article
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Canon, Jude, Rex, Karen, Saiki, Anne Y., Mohr, Christopher, Cooke, Keegan, Bagal, Dhanashri, Gaida, Kevin, Holt, Tyler, Knutson, Charles G., Koppada, Neelima, Lanman, Brian A., Werner, Jonathan, Rapaport, Aaron S., San Miguel, Tisha, Ortiz, Roberto, Osgood, Tao, Sun, Ji-Rong, Zhu, Xiaochun, McCarter, John D., Volak, Laurie P., Houk, Brett E., Fakih, Marwan G., O’Neil, Bert H., Price, Timothy J., Falchook, Gerald S., Desai, Jayesh, Kuo, James, Govindan, Ramaswamy, Hong, David S., Ouyang, Wenjun, Henary, Haby, Arvedson, Tara, Cee, Victor J., Lipford, J. Russell
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
Get full text
Journal Article
The Role of Sugar Substituents in Glycoside Hydrolysis
Namchuk, Mark N, McCarter, John D, Becalski, Adam, Andrews, Trevor, Withers, Stephen G
Published in Journal of the American Chemical Society (23.02.2000)
Published in Journal of the American Chemical Society (23.02.2000)
Get full text
Journal Article
Substrate Specificity of the Escherichia coli Outer Membrane Protease OmpT
MCCARTER, John D, STEPHENS, Daren, SHOEMAKER, Kevin, ROSENBERG, Steve, KIRSCH, Jack F, GEORGIOU, George
Published in Journal of Bacteriology (01.09.2004)
Published in Journal of Bacteriology (01.09.2004)
Get full text
Journal Article
IgG1 Thioether Bond Formation in Vivo
Zhang, Qingchun, Schenauer, Matthew R., McCarter, John D., Flynn, Gregory C.
Published in The Journal of biological chemistry (07.06.2013)
Published in The Journal of biological chemistry (07.06.2013)
Get full text
Journal Article
Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay
Chen, Ada, Zhao, Xiaoning, Mercer, Laina, Su, Cheng, Zalameda, Leeanne, Liu, Yichin, Lembke, Amanda, Eastwood, Heather, Dang, Son, Oung, Thim, Xia, Xiaoyang, Young, Stephen W, Xiao, Shouhua, McCarter, John D
Published in Combinatorial chemistry & high throughput screening (01.09.2013)
Published in Combinatorial chemistry & high throughput screening (01.09.2013)
Get more information
Journal Article
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe
Tamayo, Nuria A, Bourbeau, Matthew P, Allen, Jennifer R, Ashton, Kate S, Chen, Jian Jeffrey, Kaller, Matthew R, Nguyen, Thomas T, Nishimura, Nobuko, Pettus, Liping H, Walton, Mary, Belmontes, Brian, Moriguchi, Jodi, Chen, Kui, McCarter, John D, Hanestad, Kelly, Chung, Grace, Ninniri, Maria Stefania S, Sun, Jan, Poppe, Leszek, Spahr, Chris, Hui, John, Jia, Lei, Wu, Tian, Dahal, Upendra P, Edson, Katheryne Z, Payton, Marc
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
Get full text
Journal Article
Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
Get full text
Journal Article
Development of a High-Throughput Affinity Mass Spectrometry (AMS) Platform Using Laser Diode Thermal Desorption Ionization Coupled to Mass Spectrometry (LDTD-MS)
Sahasrabuddhe, Aniruddha, Oakley, Dylan, Chen, Kui, McCarter, John D.
Published in SLAS discovery (01.02.2021)
Published in SLAS discovery (01.02.2021)
Get full text
Journal Article
Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase
Allen, John G, Mujacic, Mirna, Frohn, Michael J, Pickrell, Alex J, Kodama, Paul, Bagal, Dhanashri, San Miguel, Tisha, Sickmier, E. Allen, Osgood, Steve, Swietlow, Aleksander, Li, Vivian, Jordan, John B, Kim, Ki-Won, Rousseau, Anne-Marie C, Kim, Yong-Jae, Caille, Seb, Achmatowicz, Mike, Thiel, Oliver, Fotsch, Christopher H, Reddy, Pranhitha, McCarter, John D
Published in ACS chemical biology (21.10.2016)
Published in ACS chemical biology (21.10.2016)
Get full text
Journal Article
High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow
Campuzano, Iain D G, San Miguel, Tisha, Rowe, Todd, Onea, Daniel, Cee, Victor J, Arvedson, Tara, McCarter, John D
Published in Journal of biomolecular screening (01.02.2016)
Published in Journal of biomolecular screening (01.02.2016)
Get full text
Journal Article
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers
Payton, Marc, Belmontes, Brian, Hanestad, Kelly, Moriguchi, Jodi, Chen, Kui, McCarter, John D, Chung, Grace, Ninniri, Maria Stefania, Sun, Jan, Manoukian, Raffi, Chambers, Stuart, Ho, Seok-Man, Kurzeja, Robert J M, Edson, Katheryne Z, Dahal, Upendra P, Wu, Tian, Wannberg, Sharon, Beltran, Pedro J, Canon, Jude, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Minocherhomji, Sheroy, Bourbeau, Matthew P, Allen, Jennifer R, Coxon, Angela, Tamayo, Nuria A, Hughes, Paul E
Published in Nature cancer (01.01.2024)
Published in Nature cancer (01.01.2024)
Get more information
Journal Article
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L. Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J. Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
Get full text
Journal Article
Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
Get full text
Journal Article