Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
Kim, Dongsung, Herdeis, Lorenz, Rudolph, Dorothea, Zhao, Yulei, Böttcher, Jark, Vides, Alberto, Ayala-Santos, Carlos I., Pourfarjam, Yasin, Cuevas-Navarro, Antonio, Xue, Jenny Y., Mantoulidis, Andreas, Bröker, Joachim, Wunberg, Tobias, Schaaf, Otmar, Popow, Johannes, Wolkerstorfer, Bernhard, Kropatsch, Katrin Gabriele, Qu, Rui, de Stanchina, Elisa, Sang, Ben, Li, Chuanchuan, McConnell, Darryl B., Kraut, Norbert, Lito, Piro
Published in Nature (London) (06.07.2023)
Published in Nature (London) (06.07.2023)
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Journal Article
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor
Bröker, Joachim, Waterson, Alex G., Smethurst, Chris, Kessler, Dirk, Böttcher, Jark, Mayer, Moriz, Gmaschitz, Gerhard, Phan, Jason, Little, Andrew, Abbott, Jason R., Sun, Qi, Gmachl, Michael, Rudolph, Dorothea, Arnhof, Heribert, Rumpel, Klaus, Savarese, Fabio, Gerstberger, Thomas, Mischerikow, Nikolai, Treu, Matthias, Herdeis, Lorenz, Wunberg, Tobias, Gollner, Andreas, Weinstabl, Harald, Mantoulidis, Andreas, Krämer, Oliver, McConnell, Darryl B., W. Fesik, Stephen
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology
McConnell, Beth B., Ghaleb, Amr M., Nandan, Mandayam O., Yang, Vincent W.
Published in BioEssays (01.06.2007)
Published in BioEssays (01.06.2007)
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Journal Article
Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design
Geist, Leonhard, Mayer, Moriz, Cockcroft, Xiao-Ling, Wolkerstorfer, Bernhard, Kessler, Dirk, Engelhardt, Harald, McConnell, Darryl B, Konrat, Robert
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
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Journal Article
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS
Hodges, Timothy R, Abbott, Jason R, Little, Andrew J, Sarkar, Dhruba, Salovich, James M, Howes, Jennifer E, Akan, Denis T, Sai, Jiqing, Arnold, Allison L, Browning, Carrie, Burns, Michael C, Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A, Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, McConnell, Darryl B, Fesik, Stephen W
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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Journal Article
Krüppel-Like Factor 5 Is Important for Maintenance of Crypt Architecture and Barrier Function in Mouse Intestine
McConnell, Beth B, Kim, Samuel S, Yu, Ke, Ghaleb, Amr M, Takeda, Norifumi, Manabe, Ichiro, Nusrat, Asma, Nagai, Ryozo, Yang, Vincent W
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2011)
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Journal Article
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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Journal Article
Use of complementary and alternative medicine in an urban county hospital epilepsy clinic
McConnell, B.V, Applegate, M, Keniston, A, Kluger, B, Maa, E.H
Published in Epilepsy & behavior (01.05.2014)
Published in Epilepsy & behavior (01.05.2014)
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Journal Article
Dynamic Volume Computed Tomography Imaging of the Upper Airway in Obstructive Sleep Apnea
Fleck, Robert J, Ishman, Stacey L, Shott, Sally R, Gutmark, Ephraim J, McConnell, Keith B, Mahmoud, Mohamed, Mylavarapu, Goutham, Subramaniam, Dhananjay R, Szczesniak, Rhonda, Amin, Raouf S
Published in Journal of clinical sleep medicine (15.02.2017)
Published in Journal of clinical sleep medicine (15.02.2017)
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Journal Article
Notch1 Regulates the Effects of Matrix Metalloproteinase-9 on Colitis-Associated Cancer in Mice
Garg, Pallavi, Jeppsson, Sabrina, Dalmasso, Guillaume, Ghaleb, Amr M, McConnell, Beth B, Yang, Vincent W, Gewirtz, Andrew T, Merlin, Didier, Sitaraman, Shanthi V
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2011)
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Journal Article
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
Stott, F J, Bates, S, James, M C, McConnell, B B, Starborg, M, Brookes, S, Palmero, I, Ryan, K, Hara, E, Vousden, K H, Peters, G
Published in The EMBO journal (01.09.1998)
Published in The EMBO journal (01.09.1998)
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Journal Article
Krüppel-Like Factor 5 Protects Against Dextran Sulfate Sodium−Induced Colonic Injury in Mice by Promoting Epithelial Repair
McConnell, Beth B, Kim, Samuel S, Bialkowska, Agnieszka B, Yu, Ke, Sitaraman, Shanthi V, Yang, Vincent W
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2011)
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Journal Article
Targeting Son of Sevenless 1: The pacemaker of KRAS
Kessler, Dirk, Gerlach, Daniel, Kraut, Norbert, McConnell, Darryl B.
Published in Current opinion in chemical biology (01.06.2021)
Published in Current opinion in chemical biology (01.06.2021)
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Journal Article
TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers
CONWAY, Kerry E, MCCONNELL, Beth B, BOWRING, Claire E, DONALD, Carlton D, WARREN, Stephen T, VERTINO, Paula M
Published in Cancer research (Chicago, Ill.) (15.11.2000)
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Published in Cancer research (Chicago, Ill.) (15.11.2000)
Journal Article
Stopping the beating heart of cancer: KRAS reviewed
Herdeis, Lorenz, Gerlach, Daniel, McConnell, Darryl B., Kessler, Dirk
Published in Current opinion in structural biology (01.12.2021)
Published in Current opinion in structural biology (01.12.2021)
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Journal Article