Molecular basis of human CD22 function and therapeutic targeting
Ereño-Orbea, June, Sicard, Taylor, Cui, Hong, Mazhab-Jafari, Mohammad T., Benlekbir, Samir, Guarné, Alba, Rubinstein, John L., Julien, Jean-Philippe
Published in Nature communications (02.10.2017)
Published in Nature communications (02.10.2017)
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Journal Article
An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis
Mazhab-Jafari, Mohammad T., Marshall, Christopher B., Ishiyama, Noboru, Ho, Jason, Di Palma, Vanessa, Stambolic, Vuk, Ikura, Mitsuhiko
Published in Structure (London) (05.09.2012)
Published in Structure (London) (05.09.2012)
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Journal Article
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
Mazhab-Jafari, Mohammad T., Marshall, Christopher B., Smith, Matthew J., Gasmi-Seabrook, Geneviève M. C., Stathopulos, Peter B., Inagaki, Fuyuhiko, Kay, Lewis E., Neel, Benjamin G., Ikura, Mitsuhiko
Published in Proceedings of the National Academy of Sciences - PNAS (26.05.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (26.05.2015)
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Journal Article
The auto-inhibitory role of the EPAC hinge helix as mapped by NMR
Selvaratnam, Rajeevan, Mazhab-Jafari, Mohammad T, Das, Rahul, Melacini, Giuseppe
Published in PloS one (21.11.2012)
Published in PloS one (21.11.2012)
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Journal Article
The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis
Puumala, Emily, Zaslaver, Olga, Chen, Amy, Duncan, Dustin, Fogal, Meea, Shapiro, Rebecca S, Mazhab-Jafari, Mohammad T, Whitesell, Luke, Montenegro-Burke, J Rafael, Robbins, Nicole, Cowen, Leah E
Published in mBio (20.12.2022)
Published in mBio (20.12.2022)
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Journal Article
A Comparative CEST NMR Study of Slow Conformational Dynamics of Small GTPases Complexed with GTP and GTP Analogues
Long, Dong, Marshall, Christopher B., Bouvignies, Guillaume, Mazhab-Jafari, Mohammad T., Smith, Matthew J., Ikura, Mitsuhiko, Kay, Lewis E.
Published in Angewandte Chemie International Edition (04.10.2013)
Published in Angewandte Chemie International Edition (04.10.2013)
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Journal Article
Membrane-Dependent Modulation of the mTOR Activator Rheb: NMR Observations of a GTPase Tethered to a Lipid-Bilayer Nanodisc
Mazhab-Jafari, Mohammad T, Marshall, Christopher B, Stathopulos, Peter B, Kobashigawa, Yoshihiro, Stambolic, Vuk, Kay, Lewis E, Inagaki, Fuyuhiko, Ikura, Mitsuhiko
Published in Journal of the American Chemical Society (06.03.2013)
Published in Journal of the American Chemical Society (06.03.2013)
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Journal Article
Structure of the murine lysosomal multienzyme complex core
Gorelik, Alexei, Illes, Katalin, Hasan, S M Naimul, Nagar, Bhushan, Mazhab-Jafari, Mohammad T
Published in Science advances (01.05.2021)
Published in Science advances (01.05.2021)
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Journal Article
Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)
Mazhab-Jafari, Mohammad T., Marshall, Christopher B., Ho, Jason, Ishiyama, Noboru, Stambolic, Vuk, Ikura, Mitsuhiko
Published in The Journal of biological chemistry (02.05.2014)
Published in The Journal of biological chemistry (02.05.2014)
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Journal Article
Acyl‐CoA Thioesterase 1 Contributes to Transition of Steatosis to Metabolic‐Associated Steatohepatitis
Pasini, Elisa, Baciu, Cristina, Angeli, Marc, Arendt, Bianca, Pellegrina, Diogo, Reimand, Jüri, Patel, Keyur
Published in International journal of hepatology (New York) (11.07.2024)
Published in International journal of hepatology (New York) (11.07.2024)
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Journal Article
Direct structural analysis of a single acyl carrier protein domain in fatty acid synthase from the fungus Saccharomyces cerevisiae
Samani, Elnaz Khalili, Chen, Amy C., Lou, Jennifer W., Dai, David L., Keszei, Alexander F. A., Tan, Guihong, Boone, Charles, Grininger, Martin, Mazhab-Jafari, Mohammad T.
Published in Communications biology (12.01.2024)
Published in Communications biology (12.01.2024)
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Journal Article
Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP
Das, Rahul, Mazhab-Jafari, Mohammad T., Chowdhury, Somenath, SilDas, Soumita, Selvaratnam, Rajeevan, Melacini, Giuseppe
Published in The Journal of biological chemistry (11.07.2008)
Published in The Journal of biological chemistry (11.07.2008)
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Journal Article
Atomic model for the membrane-embedded V O motor of a eukaryotic V-ATPase
Mazhab-Jafari, Mohammad T, Rohou, Alexis, Schmidt, Carla, Bueler, Stephanie A, Benlekbir, Samir, Robinson, Carol V, Rubinstein, John L
Published in Nature (London) (03.11.2016)
Published in Nature (London) (03.11.2016)
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Journal Article
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation
Xu, Zhang, Choi, Jung-Hyun, Dai, David L., Luo, Jun, Ladak, Reese Jalal, Li, Qian, Wang, Yimeng, Zhang, Christine, Wiebe, Shane, Liu, Alex C. H., Ran, Xiaozhuo, Yang, Jiaqi, Naeli, Parisa, Garzia, Aitor, Zhou, Lele, Mahmood, Niaz, Deng, Qiyun, Elaish, Mohamed, Lin, Rongtuan, Mahal, Lara K., Hobman, Tom C., Pelletier, Jerry, Alain, Tommy, Vidal, Silvia M., Duchaine, Thomas, Mazhab-Jafari, Mohammad T., Mao, Xiaojuan, Jafarnejad, Seyed Mehdi, Sonenberg, Nahum
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2022)
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Journal Article
Structure of the immunoregulatory sialidase NEU1
Gorelik, Alexei, Illes, Katalin, Mazhab-Jafari, Mohammad T, Nagar, Bhushan
Published in Science advances (19.05.2023)
Published in Science advances (19.05.2023)
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Journal Article