Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
Agustí, Alvar, Edwards, Lisa D, Rennard, Stephen I, MacNee, William, Tal-Singer, Ruth, Miller, Bruce E, Vestbo, Jørgen, Lomas, David A, Calverley, Peter M A, Wouters, Emiel, Crim, Courtney, Yates, Julie C, Silverman, Edwin K, Coxson, Harvey O, Bakke, Per, Mayer, Ruth J, Celli, Bartolome
Published in PloS one (18.05.2012)
Published in PloS one (18.05.2012)
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Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers
Yang, Lucy, Cheriyan, Joseph, Gutterman, David D, Mayer, Ruth J, Ament, Zsuzsanna, Griffin, Jules L, Lazaar, Aili L, Newby, David E, Tal-Singer, Ruth, Wilkinson, Ian B
Published in Chest (01.03.2017)
Published in Chest (01.03.2017)
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Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor
Lazaar, Aili L., Yang, Lucy, Boardley, Rebecca L., Goyal, Navin S., Robertson, Jonathan, Baldwin, Sandra J., Newby, David E., Wilkinson, Ian B., Tal‐Singer, Ruth, Mayer, Ruth J., Cheriyan, Joseph
Published in British journal of clinical pharmacology (01.05.2016)
Published in British journal of clinical pharmacology (01.05.2016)
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Circulating soluble receptor for advanced glycation end products (sRAGE) as a biomarker of emphysema and the RAGE axis in the lung
Yonchuk, John G, Silverman, Edwin K, Bowler, Russell P, Agustí, Alvar, Lomas, David A, Miller, Bruce E, Tal-Singer, Ruth, Mayer, Ruth J
Published in American journal of respiratory and critical care medicine (01.10.2015)
Published in American journal of respiratory and critical care medicine (01.10.2015)
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Different Mitogen-Activated Protein Kinase-Dependent Cytokine Responses in Cells of the Monocyte Lineage
Tudhope, Susan J, Finney-Hayward, Tricia K, Nicholson, Andrew G, Mayer, Ruth J, Barnette, Mary S, Barnes, Peter J, Donnelly, Louise E
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
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A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease
Menche, Jörg, Sharma, Amitabh, Cho, Michael H, Mayer, Ruth J, Rennard, Stephen I, Celli, Bartolome, Miller, Bruce E, Locantore, Nick, Tal-Singer, Ruth, Ghosh, Soumitra, Larminie, Chris, Bradley, Glyn, Riley, John H, Agusti, Alvar, Silverman, Edwin K, Barabási, Albert-László
Published in BMC systems biology (13.03.2014)
Published in BMC systems biology (13.03.2014)
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Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis
Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-Michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-Jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R
Published in Molecular therapy. Nucleic acids (01.01.2013)
Published in Molecular therapy. Nucleic acids (01.01.2013)
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Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease
Wiegman, Coen H., PhD, Michaeloudes, Charalambos, PhD, Haji, Gulammehdi, MD, Narang, Priyanka, PhD, Clarke, Colin J., MSc, Russell, Kirsty E., PhD, Bao, Wuping, MD, Pavlidis, Stelios, PhD, Barnes, Peter J., MD, Kanerva, Justin, MSc, Bittner, Anton, PhD, Rao, Navin, PhD, Murphy, Michael P., PhD, Kirkham, Paul A., PhD, Chung, Kian Fan, MD, Adcock, Ian M., PhD
Published in Journal of allergy and clinical immunology (01.09.2015)
Published in Journal of allergy and clinical immunology (01.09.2015)
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Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660)
Miller, Bruce E., Mayer, Ruth J., Goyal, Navin, Bal, Joanne, Dallow, Nigel, Boyce, Malcolm, Carpenter, Donald, Churchill, Alison, Heslop, Teresa, Lazaar, Aili L.
Published in British journal of clinical pharmacology (01.12.2017)
Published in British journal of clinical pharmacology (01.12.2017)
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Activation of Human Leukocytes Reduces Surface P-Selectin Glycoprotein Ligand-1 (PSGL-1, CD162) and Adhesion to P-Selectin In Vitro
Davenpeck, Kelly L, Brummet, Mary E, Hudson, Sherry A, Mayer, Ruth J, Bochner, Bruce S
Published in The Journal of immunology (1950) (01.09.2000)
Published in The Journal of immunology (1950) (01.09.2000)
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Systemic Soluble Receptor for Advanced Glycation Endproducts Is a Biomarker of Emphysema and Associated with AGER Genetic Variants in Patients with Chronic Obstructive Pulmonary Disease
CHENG, Donavan T, DEOG KYEOM KIM, REYNAERT, Niki, TAL-SINGER, Ruth, WOUTERS, Emiel F. M, AGUSTI, Alvar, FABBRI, Leonardo M, RAMES, Alex, VISVANATHAN, Sudha, RENNARD, Stephen I, JONES, Paul, PARMAR, Harsukh, COCKAYNE, Debra A, MACNEE, William, WOLFF, Gerhard, SILVERMAN, Edwin K, MAYER, Ruth J, PILLAI, Sreekumar G, BELOUSOV, Anton, BITTER, Hans, CHO, Michael H, DUVOIX, Annelyse, EDWARDS, Lisa D, LOMAS, David A, MILLER, Bruce E
Published in American journal of respiratory and critical care medicine (15.10.2013)
Published in American journal of respiratory and critical care medicine (15.10.2013)
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Danirixin: A Reversible and Selective Antagonist of the CXC Chemokine Receptor 2
Busch-Petersen, Jakob, Carpenter, Donald C, Burman, Miriam, Foley, James, Hunsberger, Gerald E, Kilian, David J, Salmon, Michael, Mayer, Ruth J, Yonchuk, John G, Tal-Singer, Ruth
Published in The Journal of pharmacology and experimental therapeutics (01.08.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2017)
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In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor
Podolin, Patricia L., Bolognese, Brian J., Foley, Joseph F., Long, Edward, Peck, Brian, Umbrecht, Sandra, Zhang, Xiaojun, Zhu, Penny, Schwartz, Benjamin, Xie, Wensheng, Quinn, Chad, Qi, Hongwei, Sweitzer, Sharon, Chen, Stephanie, Galop, Marc, Ding, Yun, Belyanskaya, Svetlana L., Israel, David I., Morgan, Barry A., Behm, David J., Marino, Joseph P., Kurali, Edit, Barnette, Mary S., Mayer, Ruth J., Booth-Genthe, Catherine L., Callahan, James F.
Published in Prostaglandins & other lipid mediators (01.07.2013)
Published in Prostaglandins & other lipid mediators (01.07.2013)
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Gene expression changes caused by the p38 MAPK inhibitor dilmapimod in COPD patients: analysis of blood and sputum samples from a randomized, placebo‐controlled clinical trial
Betts, Joanna C., Mayer, Ruth J., Tal‐Singer, Ruth, Warnock, Linda, Clayton, Chris, Bates, Stewart, Hoffman, Bryan E., Larminie, Christopher, Singh, Dave
Published in Pharmacology research & perspectives (01.02.2015)
Published in Pharmacology research & perspectives (01.02.2015)
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Inhibitors of the p38 Mitogen-Activated Kinase Modulate IL-4 Induction of Low Affinity IgE Receptor (CD23) in Human Monocytes
Marshall, Lisa A, Hansbury, Michael J, Bolognese, Brian J, Gum, Rebecca J, Young, Peter R, Mayer, Ruth J
Published in The Journal of immunology (1950) (01.12.1998)
Published in The Journal of immunology (1950) (01.12.1998)
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Metabolic re-patterning in COPD airway smooth muscle cells
Michaeloudes, Charalambos, Kuo, Chih-Hsi, Haji, Gulam, Finch, Donna K, Halayko, Andrew J, Kirkham, Paul, Chung, Kian Fan, Adcock, Ian M
Published in The European respiratory journal (01.11.2017)
Published in The European respiratory journal (01.11.2017)
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Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD
Bewley, Martin A, Belchamber, Kylie B R, Chana, Kirandeep K, Budd, Richard C, Donaldson, Gavin, Wedzicha, Jadwiga A, Brightling, Christopher E, Kilty, Iain, Donnelly, Louise E, Barnes, Peter J, Singh, Dave, Whyte, Moira K B, Dockrell, David H
Published in PloS one (28.09.2016)
Published in PloS one (28.09.2016)
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The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study
Coxson, Harvey O, Dirksen, Asger, Edwards, Lisa D, Yates, Julie C, Agusti, Alvar, Bakke, Per, Calverley, Peter Ma, Celli, Bartolome, Crim, Courtney, Duvoix, Annelyse, Fauerbach, Paola Nasute, Lomas, David A, Macnee, William, Mayer, Ruth J, Miller, Bruce E, Müller, Nestor L, Rennard, Stephen I, Silverman, Edwin K, Tal-Singer, Ruth, Wouters, Emiel Fm, Vestbo, Jørgen
Published in The lancet respiratory medicine (01.04.2013)
Published in The lancet respiratory medicine (01.04.2013)
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