SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
Luthi-Carter, Ruth, Taylor, David M, Pallos, Judit, Lambert, Emmanuel, Amore, Allison, Parker, Alex, Moffitt, Hilary, Smith, Donna L, Runne, Heike, Gokce, Ozgun, Kuhn, Alexandre, Xiang, Zhongmin, Maxwell, Michele M, Reeves, Steven A, Bates, Gillian P, Neri, Christian, Thompson, Leslie M, Marsh, J. Lawrence, Kazantsev, Aleksey G
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2010)
Get full text
Journal Article
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models
Quinti, Luisa, Casale, Malcolm, Moniot, Sébastien, Pais, Teresa F., Van Kanegan, Michael J., Kaltenbach, Linda S., Pallos, Judit, Lim, Ryan G., Naidu, Sharadha Dayalan, Runne, Heike, Meisel, Lisa, Rauf, Nazifa Abdul, Leyfer, Dmitriy, Maxwell, Michele M., Saiah, Eddine, Landers, John E., Luthi-Carter, Ruth, Abagyan, Ruben, Dinkova-Kostova, Albena T., Steegborn, Clemens, Marsh, J. Lawrence, Lo, Donald C., Thompson, Leslie M., Kazantsev, Aleksey G.
Published in Cell chemical biology (21.07.2016)
Published in Cell chemical biology (21.07.2016)
Get full text
Journal Article
A Potent Small Molecule Inhibits Polyglutamine Aggregation in Huntington's Disease Neurons and Suppresses Neurodegeneration in vivo
Zhang, Xiaoqian, Smith, Donna L., Meriin, Anatoli B., Engemann, Sabine, Russel, Deborah E., Roark, Margo, Washington, Shetia L., Maxwell, Michele M., Marsh, J. Lawrence, Thompson, Leslie Michels, Wanker, Erich E., Young, Anne B., Housman, David E., Bates, Gillian P., Sherman, Michael Y., Kazantsev, Aleksey G.
Published in Proceedings of the National Academy of Sciences - PNAS (18.01.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (18.01.2005)
Get full text
Journal Article
Pharmacological Promotion of Inclusion Formation: A Therapeutic Approach for Huntington's and Parkinson's Diseases
Bodner, Ruth A., Outeiro, Tiago Fleming, Altmann, Stephen, Maxwell, Michele M., Cho, Stephanie H., Hyman, Bradley T., McLean, Pamela J., Young, Anne B., Housman, David E., Kazantsev, Aleksey G.
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2006)
Get full text
Journal Article
Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease
Outeiro, Tiago Fleming, Kontopoulos, Eirene, Altmann, Stephen M, Kufareva, Irina, Strathearn, Katherine E, Amore, Allison M, Volk, Catherine B, Maxwell, Michele M, Rochet, Jean-Christophe, McLean, Pamela J, Young, Anne B, Abagyan, Ruben, Feany, Mel B, Hyman, Bradley T, Kazantsev, Aleksey G
Published in Science (American Association for the Advancement of Science) (27.07.2007)
Published in Science (American Association for the Advancement of Science) (27.07.2007)
Get full text
Journal Article
RNA Interference-Mediated Silencing of Mutant Superoxide Dismutase Rescues Cyclosporin A-Induced Death in Cultured Neuroblastoma Cells
Maxwell, Michele M., Pasinelli, Piera, Kazantsev, Aleksey G., Brown, Robert H., Housman, David E.
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2004)
Get full text
Journal Article
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS
Maxwell, Michele M., Tomkinson, Elizabeth M., Nobles, Johnathan, Wizeman, John W., Amore, Allison M., Quinti, Luisa, Chopra, Vanita, Hersch, Steven M., Kazantsev, Aleksey G.
Published in Human molecular genetics (15.10.2011)
Published in Human molecular genetics (15.10.2011)
Get full text
Journal Article
Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease
Maxwell, Michele M., Zaldivar‐Jolissaint, Julien Francisco, Mai, Antonello, Outeiro, Tiago F., Kazanstev, Aleksey G.
Published in EMBO molecular medicine (01.07.2012)
Published in EMBO molecular medicine (01.07.2012)
Get full text
Journal Article
Conference Proceeding
A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase
Taylor, David M, Balabadra, Uma, Xiang, Zhongmin, Woodman, Ben, Meade, Sarah, Amore, Allison, Maxwell, Michele M, Reeves, Steven, Bates, Gillian P, Luthi-Carter, Ruth, Lowden, Philip A. S, Kazantsev, Aleksey G
Published in ACS chemical biology (17.06.2011)
Published in ACS chemical biology (17.06.2011)
Get full text
Journal Article
Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments
Coufal, Myra, Maxwell, Michele M, Russel, Deborah E, Amore, Allison M, Altmann, Stephen M, Hollingsworth, Zane R, Young, Anne B, Housman, David E, Kazantsev, Aleksey G
Published in Journal of biomolecular screening (01.04.2007)
Published in Journal of biomolecular screening (01.04.2007)
Get full text
Journal Article
Two approaches to drug discovery in SOD1-mediated ALS
Broom, Wendy J, Auwarter, Kristen E, Ni, Jake, Russel, Deborah E, Yeh, Li-An, Maxwell, Michele M, Glicksman, Marcie, Kazantsev, Aleksey G, Brown, Jr, Robert H
Published in Journal of biomolecular screening (01.10.2006)
Published in Journal of biomolecular screening (01.10.2006)
Get full text
Journal Article
Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation
Belanto, Joseph J, Diaz-Perez, Silvia V, Magyar, Clara E, Maxwell, Michele M, Yilmaz, Yasemin, Topp, Kasey, Boso, Guney, Jamieson, Catriona H, Cacalano, Nicholas A, Jamieson, Christina A.M
Published in Neuromuscular disorders : NMD (01.02.2010)
Published in Neuromuscular disorders : NMD (01.02.2010)
Get full text
Journal Article
Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model
Quinti, Luisa, Chopra, Vanita, Rotili, Dante, Valente, Sergio, Amore, Allison, Franci, Gianluigi, Meade, Sarah, Valenza, Marta, Altucci, Lucia, Maxwell, Michele M, Cattaneo, Elena, Hersch, Steven, Mai, Antonello, Kazantsev, Aleksey
Published in PLoS currents (02.09.2010)
Published in PLoS currents (02.09.2010)
Get full text
Journal Article
Ke 6 Gene
Maxwell, Michele M., Nearing, Jacqueline, Aziz, Nazneen
Published in The Journal of biological chemistry (20.10.1995)
Published in The Journal of biological chemistry (20.10.1995)
Get full text
Journal Article
Discovery of Bioactive Small-Molecule Inhibitor of Poly ADP-Ribose Polymerase: Implications for Energy-Deficient Cells
Altmann, Stephen M., Muryshev, Andrey, Fossale, Elisa, Maxwell, Michele M., Norflus, Francine N., Fox, Jonathan, Hersch, Steven M., Young, Anne B., MacDonald, Marcy E., Abagyan, Ruben, Kazantsev, Aleksey G.
Published in Chemistry & biology (01.07.2006)
Published in Chemistry & biology (01.07.2006)
Get full text
Journal Article
Sirtuin 2 Inhibitors Rescue [alpha]-Synuclein-Mediated Toxicity in Models of Parkinson's Disease
Outeiro, Tiago Fleming, Kontopoulos, Eirene, Altmann, Stephen M, Kufareva, Irina, Strathearn, Katherine E, Amore, Allison M, Volk, Catherine B, Maxwell, Michele M, Rochet, Jean-Christophe, McLean, Pamela J, Young, Anne B, Abagyan, Ruben, Feany, Mel B
Published in Science (American Association for the Advancement of Science) (27.07.2007)
Published in Science (American Association for the Advancement of Science) (27.07.2007)
Get full text
Journal Article
Evaluation of Histone Deacetylases as Drug Targets in Huntington’s Disease modelsStudy of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model
Quinti, Luisa, Chopra, Vanita, Rotili, Dante, Valente, Sergio, Amore, Allison, Franci, Gianluigi, Meade, Sarah, Valenza, Marta, Altucci, Lucia, Maxwell, Michele M., Cattaneo, Elena, Hersch, Steven, Mai, Antonello, Kazantsev, Aleksey
Published in PLoS currents (02.09.2010)
Published in PLoS currents (02.09.2010)
Get full text
Journal Article