A Vaccinia-based system for directed evolution of GPCRs in mammalian cells
Klenk, Christoph, Scrivens, Maria, Niederer, Anina, Shi, Shuying, Mueller, Loretta, Gersz, Elaine, Zauderer, Maurice, Smith, Ernest S., Strohner, Ralf, Plückthun, Andreas
Published in Nature communications (30.03.2023)
Published in Nature communications (30.03.2023)
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Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity
Evans, Elizabeth E, Mishra, Vikas, Mallow, Crystal, Gersz, Elaine M, Balch, Leslie, Howell, Alan, Reilly, Christine, Smith, Ernest S, Fisher, Terrence L, Zauderer, Maurice
Published in Journal of neuroinflammation (06.08.2022)
Published in Journal of neuroinflammation (06.08.2022)
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Journal Article
SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease
Smith, Ernest S, Jonason, Alan, Reilly, Christine, Veeraraghavan, Janaki, Fisher, Terrence, Doherty, Michael, Klimatcheva, Ekaterina, Mallow, Crystal, Cornelius, Chad, Leonard, John E, Marchi, Nicola, Janigro, Damir, Argaw, Azeb Tadesse, Pham, Trinh, Seils, Jennifer, Bussler, Holm, Torno, Sebold, Kirk, Renee, Howell, Alan, Evans, Elizabeth E, Paris, Mark, Bowers, William J, John, Gareth, Zauderer, Maurice
Published in Neurobiology of disease (2015)
Published in Neurobiology of disease (2015)
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Journal Article
Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease
Southwell, Amber L, Franciosi, Sonia, Villanueva, Erika B, Xie, Yuanyun, Winter, Laurie A, Veeraraghavan, Janaki, Jonason, Alan, Felczak, Boguslaw, Zhang, Weining, Kovalik, Vlad, Waltl, Sabine, Hall, George, Pouladi, Mahmoud A, Smith, Ernest S, Bowers, William J, Zauderer, Maurice, Hayden, Michael R
Published in Neurobiology of disease (01.04.2015)
Published in Neurobiology of disease (01.04.2015)
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Journal Article
CXCL13 antibody for the treatment of autoimmune disorders
Klimatcheva, Ekaterina, Pandina, Tracy, Reilly, Christine, Torno, Sebold, Bussler, Holm, Scrivens, Maria, Jonason, Alan, Mallow, Crystal, Doherty, Michael, Paris, Mark, Smith, Ernest S, Zauderer, Maurice
Published in BMC immunology (12.02.2015)
Published in BMC immunology (12.02.2015)
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Journal Article
Semaphorin4D Inhibition Improves Response to Immune-Checkpoint Blockade via Attenuation of MDSC Recruitment and Function
Clavijo, Paul E, Friedman, Jay, Robbins, Yvette, Moore, Ellen C, Smith, Ernest, Zauderer, Maurice, Evans, Elizabeth E, Allen, Clint T
Published in Cancer immunology research (01.02.2019)
Published in Cancer immunology research (01.02.2019)
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Journal Article
Anti-Semaphorin 4D Rescues Motor, Cognitive, and Respiratory Phenotypes in a Rett Syndrome Mouse Model
Mao, Yilin, Evans, Elizabeth, Mishra, Vikas, Balch, Leslie, Eberhardt, Allison, Zauderer, Maurice, Gold, Wendy
Published in International journal of molecular sciences (01.09.2021)
Published in International journal of molecular sciences (01.09.2021)
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Journal Article
Use of poxvirus display to select antibodies specific for complex membrane antigens
Smith, Ernest S., Balch, Leslie A., Scrivens, Maria, Shi, Shuying, Wang, Wei, Harvey, Caroline D., Cornelison, Angelica A., Gil-Moore, Malgorzata, Kirk, Renee A., Mueller, Loretta L., Hall, Richard L., Howell, Alan P., Reilly, Christine A., Mayer, Jessica M., Murante, Francis G., Viggiani, Kari A, Gersz, Elaine M., Bussler, Holm, Keefe, Madeleine R., Evans, Elizabeth E., Paris, Mark J., Zauderer, Maurice
Published in mAbs (31.12.2023)
Published in mAbs (31.12.2023)
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Journal Article
Safety/tolerability of the anti-semaphorin 4D antibody VX15/2503 in a randomized phase 1 trial
LaGanke, Christopher, Samkoff, Lawrence, Edwards, Keith, Jung Henson, Lily, Repovic, Pavle, Lynch, Sharon, Stone, Lael, Mattson, David, Galluzzi, Aaron, Fisher, Terrence L, Reilly, Christine, Winter, Laurie A, Leonard, John E, Zauderer, Maurice
Published in Neurology : neuroimmunology & neuroinflammation (01.07.2017)
Published in Neurology : neuroimmunology & neuroinflammation (01.07.2017)
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Journal Article
Generation and preclinical characterization of an antibody specific for SEMA4D
Fisher, Terrence L, Reilly, Christine A, Winter, Laurie A, Pandina, Tracy, Jonason, Alan, Scrivens, Maria, Balch, Leslie, Bussler, Holm, Torno, Sebold, Seils, Jennifer, Mueller, Loretta, Huang, He, Klimatcheva, Ekaterina, Howell, Alan, Kirk, Renee, Evans, Elizabeth, Paris, Mark, Leonard, John E, Smith, Ernest S, Zauderer, Maurice
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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676 Pepinemab, a semaphorin 4D inhibitor, in combination with pembrolizumab induced formation of organized lymphoid aggregates in phase 1b/2 study for first-line treatment of R/M HNSCC (KEYNOTE-B84)
Fisher, Terrence, Evans, Elizabeth, Mallow, Crystal, Foster, Amber, Leonard, John, Chaney, Marya, Mekhail, Tarek, Seetharamu, Nagashree, Steuer, Conor, Saba, Nabil F, Adkins, Douglas, Thaddeus Beck, J, Algazi, Alain, Burtness, Barbara, Baumgart, Megan, Hager, Steven, Chay, Christopher, Spira, Alexander, Zauderer, Maurice
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D
Evans, Elizabeth E, Paris, Mark, Smith, Ernest S, Zauderer, Maurice
Published in Oncoimmunology (02.12.2015)
Published in Oncoimmunology (02.12.2015)
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Journal Article
434 Phase 1/2 study to evaluate pepinemab in combination with pembrolizumab in advanced, recurrent or metastatic head and neck cancer (KEYNOTE B84)
Evans, Elizabeth, Fisher, Terrence, Mallow, Crystal, Foster, Amber, Smith, Ernest, Leonard, John, Chaney, Marya, Zauderer, Maurice
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
629 Neoadjuvant SEMA4D inhibitor pepinemab combination with nivolumab increases crosstalk between B cell and CD26hi T cell in patients with resectable stage III melanoma
Ruffin, Ayana T, Olson, Brian, Mallow, Crystal, Reilly, Christine, Hammons, Jacklyn, Kim, Jayden, Burns, Brian, Harutyunyan, Agnes, Evans, Elizabeth, Fisher, Terrence, Zauderer, Maurice, Delman, Keith A, Yushak, Melinda, Mokhtari, Ali, Parker, Douglas, Kudchadkar, Ragini, Paulos, Chrystal M, Lesinski, Gregory B, Lowe, Michael C
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer
Evans, Elizabeth E, Henn, Alicia D, Jonason, Alan, Paris, Mark J, Schiffhauer, Linda M, Borrello, Melinda A, Smith, Ernest S, Sahasrabudhe, Deepak M, Zauderer, Maurice
Published in Molecular cancer therapeutics (01.11.2006)
Published in Molecular cancer therapeutics (01.11.2006)
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Journal Article
A biological classification of Huntington's disease: the Integrated Staging System
Tabrizi, Sarah J, Schobel, Scott, Gantman, Emily C, Mansbach, Alexandra, Borowsky, Beth, Konstantinova, Pavlina, Mestre, Tiago A, Panagoulias, Jennifer, Ross, Christopher A, Zauderer, Maurice, Mullin, Ariana P, Romero, Klaus, Sivakumaran, Sudhir, Turner, Emily C, Long, Jeffrey D, Sampaio, Cristina
Published in Lancet neurology (01.07.2022)
Published in Lancet neurology (01.07.2022)
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