In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment
Allegretta, Giuseppe, Maurer, Christine K, Eberhard, Jens, Maura, Damien, Hartmann, Rolf W, Rahme, Laurence, Empting, Martin
Published in Frontiers in microbiology (24.05.2017)
Published in Frontiers in microbiology (24.05.2017)
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Journal Article
Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors
Storz, Michael P, Maurer, Christine K, Zimmer, Christina, Wagner, Nathalie, Brengel, Christian, de Jong, Johannes C, Lucas, Simon, Müsken, Mathias, Häussler, Susanne, Steinbach, Anke, Hartmann, Rolf W
Published in Journal of the American Chemical Society (03.10.2012)
Published in Journal of the American Chemical Society (03.10.2012)
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Journal Article
Antibiotic-free nanotherapeutics: Ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors
Nafee, Noha, Husari, Ayman, Maurer, Christine K., Lu, Cenbin, de Rossi, Chiara, Steinbach, Anke, Hartmann, Rolf W., Lehr, Claus-Michael, Schneider, Marc
Published in Journal of controlled release (28.10.2014)
Published in Journal of controlled release (28.10.2014)
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Journal Article
Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent Targeting pqs Quorum Sensing
Lu, Cenbin, Maurer, Christine K., Kirsch, Benjamin, Steinbach, Anke, Hartmann, Rolf W.
Published in Angewandte Chemie International Edition (20.01.2014)
Published in Angewandte Chemie International Edition (20.01.2014)
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Journal Article
Discovery and Biophysical Characterization of 2‑Amino-oxadiazoles as Novel Antagonists of PqsR, an Important Regulator of Pseudomonas aeruginosa Virulence
Zender, Michael, Klein, Tobias, Henn, Claudia, Kirsch, Benjamin, Maurer, Christine K, Kail, Dagmar, Ritter, Christiane, Dolezal, Olan, Steinbach, Anke, Hartmann, Rolf W
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence
Zender, Michael, Witzgall, Florian, Kiefer, Alexander, Kirsch, Benjamin, Maurer, Christine K., Kany, Andreas M., Xu, Ningna, Schmelz, Stefan, Börger, Carsten, Blankenfeldt, Wulf, Empting, Martin
Published in ChemMedChem (17.01.2020)
Published in ChemMedChem (17.01.2020)
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Journal Article
Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure–activity relationships
Lu, Cenbin, Kirsch, Benjamin, Maurer, Christine K., de Jong, Johannes C., Braunshausen, Andrea, Steinbach, Anke, Hartmann, Rolf W.
Published in European journal of medicinal chemistry (22.05.2014)
Published in European journal of medicinal chemistry (22.05.2014)
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Journal Article
Development and validation of a UHPLC–MS/MS procedure for quantification of the Pseudomonas Quinolone Signal in bacterial culture after acetylation for characterization of new quorum sensing inhibitors
Maurer, Christine K., Steinbach, Anke, Hartmann, Rolf W.
Published in Journal of pharmaceutical and biomedical analysis (01.12.2013)
Published in Journal of pharmaceutical and biomedical analysis (01.12.2013)
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Journal Article
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds
Zender, Michael, Witzgall, Florian, Drees, Steffen L, Weidel, Elisabeth, Maurer, Christine K, Fetzner, Susanne, Blankenfeldt, Wulf, Empting, Martin, Hartmann, Rolf W
Published in ACS chemical biology (17.06.2016)
Published in ACS chemical biology (17.06.2016)
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Journal Article
Identification of Small-Molecule Antagonists of the Pseudomonas aeruginosa Transcriptional Regulator PqsR: Biophysically Guided Hit Discovery and Optimization
Klein, Tobias, Henn, Claudia, de Jong, Johannes C, Zimmer, Christina, Kirsch, Benjamin, Maurer, Christine K, Pistorius, Dominik, Müller, Rolf, Steinbach, Anke, Hartmann, Rolf W
Published in ACS chemical biology (21.09.2012)
Published in ACS chemical biology (21.09.2012)
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Journal Article
Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
Kany, Andreas M., Sikandar, Asfandyar, Haupenthal, Jörg, Yahiaoui, Samir, Maurer, Christine K., Proschak, Ewgenij, Köhnke, Jesko, Hartmann, Rolf W.
Published in ACS infectious diseases (08.06.2018)
Published in ACS infectious diseases (08.06.2018)
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Journal Article
Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies
Maurer, Christine K, Fruth, Martina, Empting, Martin, Avrutina, Olga, Hoßmann, Jörn, Nadmid, Suvd, Gorges, Jan, Herrmann, Jennifer, Kazmaier, Uli, Dersch, Petra, Müller, Rolf, Hartmann, Rolf W
Published in Future medicinal chemistry (01.06.2016)
Published in Future medicinal chemistry (01.06.2016)
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Journal Article
Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa
Lu, Cenbin, Kirsch, Benjamin, Zimmer, Christina, de Jong, Johannes C., Henn, Claudia, Maurer, Christine K., Müsken, Mathias, Häussler, Susanne, Steinbach, Anke, Hartmann, Rolf W.
Published in Chemistry & biology (23.03.2012)
Published in Chemistry & biology (23.03.2012)
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Journal Article
Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies
Steinbach, Anke, Maurer, Christine K, Weidel, Elisabeth, Henn, Claudia, Brengel, Christian, Hartmann, Rolf W, Negri, Matthias
Published in BMC biophysics (01.08.2013)
Published in BMC biophysics (01.08.2013)
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Journal Article
Front Cover: Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence (ChemMedChem 2/2020)
Zender, Michael, Witzgall, Florian, Kiefer, Alexander, Kirsch, Benjamin, Maurer, Christine K., Kany, Andreas M., Xu, Ningna, Schmelz, Stefan, Börger, Carsten, Blankenfeldt, Wulf, Empting, Martin
Published in ChemMedChem (17.01.2020)
Published in ChemMedChem (17.01.2020)
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Journal Article
Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An InVivo Potent Antivirulence Agent Targeting pqs Quorum Sensing
Lu, Cenbin, Maurer, Christine K, Kirsch, Benjamin, Steinbach, Anke, Hartmann, Rolf W
Published in Angewandte Chemie International Edition (01.01.2014)
Published in Angewandte Chemie International Edition (01.01.2014)
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Journal Article
Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent Targeting pqs Quorum Sensing
Lu, Cenbin, Maurer, Christine K., Kirsch, Benjamin, Steinbach, Anke, Hartmann, Rolf W.
Published in Angewandte Chemie (20.01.2014)
Published in Angewandte Chemie (20.01.2014)
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Journal Article
Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An InVivo Potent Antivirulence Agent Targeting pqs Quorum Sensing
Lu, Cenbin, Maurer, Christine K, Kirsch, Benjamin, Steinbach, Anke, Hartmann, Rolf W
Published in Angewandte Chemie (01.01.2014)
Published in Angewandte Chemie (01.01.2014)
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Journal Article