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Wagner, Rolf, Randolph, John T, Patel, Sachin V, Nelson, Lissa, Matulenko, Mark A, Keddy, Ryan, Pratt, John K, Liu, Dachun, Krueger, A. Chris, Donner, Pamela L, Hutchinson, Douglas K, Flentge, Charles, Betebenner, David, Rockway, Todd, Maring, Clarence J, Ng, Teresa I, Krishnan, Preethi, Pilot-Matias, Tami, Collins, Christine, Panchal, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Mondal, Rubina, Stolarik, DeAnne F, Gao, Yi, Gao, Wenqing, Beno, David A, Kati, Warren M
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Published in Journal of medicinal chemistry (10.05.2018)
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Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson’s Disease
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Published in Journal of organic chemistry (18.02.2022)
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DeGoey, David A., Randolph, John T., Liu, Dachun, Pratt, John, Hutchins, Charles, Donner, Pamela, Krueger, A. Chris, Matulenko, Mark, Patel, Sachin, Motter, Christopher E., Nelson, Lissa, Keddy, Ryan, Tufano, Michael, Caspi, Daniel D., Krishnan, Preethi, Mistry, Neeta, Koev, Gennadiy, Reisch, Thomas J., Mondal, Rubina, Pilot-Matias, Tami, Gao, Yi, Beno, David W. A., Maring, Clarence J., Molla, Akhter, Dumas, Emily, Campbell, Andrew, Williams, Laura, Collins, Christine, Wagner, Rolf, Kati, Warren M.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Jarvis, Michael F, Honore, Prisca, Shieh, Char-Chang, Chapman, Mark, Joshi, Shailen, Zhang, Xu-Feng, Kort, Michael, Carroll, William, Marron, Brian, Atkinson, Robert, Thomas, James, Liu, Dong, Krambis, Michael, Liu, Yi, McGaraughty, Steve, Chu, Katharine, Roeloffs, Rosemarie, Zhong, Chengmin, Mikusa, Joseph P, Hernandez, Gricelda, Gauvin, Donna, Wade, Carrie, Zhu, Chang, Pai, Madhavi, Scanio, Marc, Shi, Lei, Drizin, Irene, Gregg, Robert, Matulenko, Mark, Hakeem, Ahmed, Gross, Michael, Johnson, Matthew, Marsh, Kennan, Wagoner, P. Kay, Sullivan, James P, Faltynek, Connie R, Krafte, Douglas S
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Published in Proceedings of the National Academy of Sciences - PNAS (15.05.2007)
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Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
Frost, Jennifer M, DeGoey, David A, Shi, Lei, Gum, Rebecca J, Fricano, Meagan M, Lundgaard, Greta L, El-Kouhen, Odile F, Hsieh, Gin C, Neelands, Torben, Matulenko, Mark A, Daanen, Jerome F, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Zhan, Cenchen, Zhang, Xu-Feng, Kort, Michael E
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels
Dubé, G.R., Lehto, Sonya G., Breese, Nicole M., Baker, Scott J., Wang, Xueqing, Matulenko, Mark A., Honoré, Prisca, Stewart, Andrew O., Moreland, Robert B., Brioni, Jorge D.
Published in Pain (Amsterdam) (01.09.2005)
Published in Pain (Amsterdam) (01.09.2005)
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Voltage-gated sodium channel blockers for the treatment of chronic pain
Matulenko, Mark A, Scanio, Marc J C, Kort, Michael E
Published in Current topics in medicinal chemistry (01.03.2009)
Published in Current topics in medicinal chemistry (01.03.2009)
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A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats
Zhang, Xu-Feng, Shieh, Char-Chang, Chapman, Mark L, Matulenko, Mark A, Hakeem, Ahmed H, Atkinson, Robert N, Kort, Michael E, Marron, Brian E, Joshi, Shailen, Honore, Prisca, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F
Published in Neuropharmacology (01.09.2010)
Published in Neuropharmacology (01.09.2010)
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Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives
Kort, Michael E, Atkinson, Robert N, Thomas, James B, Drizin, Irene, Johnson, Matthew S, Secrest, Matthew A, Gregg, Robert J, Scanio, Marc J C, Shi, Lei, Hakeem, Ahmed H, Matulenko, Mark A, Chapman, Mark L, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Werness, Stephen, Antonio, Brett, Marsh, Kennan C, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Marron, Brian E
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Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Discovery of 3-Methyl-N-(1-oxy-3‘,4‘,5‘,6‘-tetrahydro-2‘H-[2,4‘-bipyridine]-1‘-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D4 Agonist for the Treatment of Erectile Dysfunction
Patel, Meena V, Kolasa, Teodozyj, Mortell, Kathleen, Matulenko, Mark A, Hakeem, Ahmed A, Rohde, Jeffrey J, Nelson, Sherry L, Cowart, Marlon D, Nakane, Masaki, Miller, Loan N, Uchic, Marie E, Terranova, Marc A, El-Kouhen, Odile F, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Chang, Renjie, Martino, Brenda R, Wetter, Jill M, Marsh, Kennan C, Martin, Ruth, Darbyshire, John F, Gintant, Gary, Hsieh, Gin C, Moreland, Robert B, Sullivan, James P, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (14.12.2006)
Published in Journal of medicinal chemistry (14.12.2006)
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Crystal Structures of Human Adenosine Kinase Inhibitor Complexes Reveal Two Distinct Binding Modes
Muchmore, Steven W, Smith, Richard A, Stewart, Andrew O, Cowart, Marlon D, Gomtsyan, Arthur, Matulenko, Mark A, Yu, Haixia, Severin, Jean M, Bhagwat, Shripad S, Lee, Chih-Hung, Kowaluk, Elizabeth A, Jarvis, Michael F, Jakob, Clarissa L
Published in Journal of medicinal chemistry (16.11.2006)
Published in Journal of medicinal chemistry (16.11.2006)
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4-Amino-5-aryl-6-arylethynylpyrimidines: Structure–activity relationships of non-nucleoside adenosine kinase inhibitors
Matulenko, Mark A., Paight, Ernest S., Frey, Robin R., Gomtsyan, Arthur, DiDomenico, Stanley, Jiang, Meiqun, Lee, Chih-Hung, Stewart, Andrew O., Yu, Haixia, Kohlhaas, Kathy L., Alexander, Karen M., McGaraughty, Steve, Mikusa, Joseph, Marsh, Kennan C., Muchmore, Steven W., Jakob, Clarissa L., Kowaluk, Elizabeth A., Jarvis, Michael F., Bhagwat, Shripad S.
Published in Bioorganic & medicinal chemistry (15.02.2007)
Published in Bioorganic & medicinal chemistry (15.02.2007)
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XUEQING WANG, BHATIA, Pramila A, MILLER, Loan N, RENJIE CHANG, MORELAND, Robert B, BRIONI, Jorge D, STEWART, Andrew O, DAANEN, Jerome F, LATSAW, Steve P, ROHDE, Jeffrey, KOLASA, Teodozyi, HAKEEM, Ahmed A, MATULENKO, Mark A, NAKANE, Masaki, UCHIC, Marie E
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Published in Bioorganic & medicinal chemistry (01.08.2005)
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5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure–activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors
Matulenko, Mark A., Lee, Chih-Hung, Jiang, Meiqun, Frey, Robin R., Cowart, Marlon D., Bayburt, Erol K., DiDomenico, Stanley, Gfesser, Gregory A., Gomtsyan, Arthur, Zheng, Guo Zhu, McKie, Jeffery A., Stewart, Andrew O., Yu, Haixia, Kohlhaas, Kathy L., Alexander, Karen M., McGaraughty, Steve, Wismer, Carol T., Mikusa, Joseph, Marsh, Kennan C., Snyder, Ronald D., Diehl, Marilyn S., Kowaluk, Elizabeth A., Jarvis, Michael F., Bhagwat, Shripad S.
Published in Bioorganic & medicinal chemistry (01.06.2005)
Published in Bioorganic & medicinal chemistry (01.06.2005)
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Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists
Matulenko, Mark A, Hakeem, Ahmed A, Kolasa, Teodozyi, Nakane, Masaki, Terranova, Marc A, Uchic, Marie E, Miller, Loan N, Chang, Renjie, Donnelly-Roberts, Diana L, Namovic, Marian T, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Bioorganic & medicinal chemistry (01.07.2004)
Published in Bioorganic & medicinal chemistry (01.07.2004)
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Design, Synthesis, and Structure−Activity Relationship of 6-Alkynylpyrimidines as Potent Adenosine Kinase Inhibitors
Gomtsyan, Arthur, Didomenico, Stanley, Lee, Chih-Hung, Matulenko, Mark A, Kim, Ki, Kowaluk, Elizabeth A, Wismer, Carol T, Mikusa, Joe, Yu, Haixia, Kohlhaas, Kathy, Jarvis, Michael F, Bhagwat, Shripad S
Published in Journal of medicinal chemistry (15.08.2002)
Published in Journal of medicinal chemistry (15.08.2002)
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1-Aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one Oximes as Potent Dopamine D4 Receptor Agonists for the Treatment of Erectile Dysfunction
Kolasa, Teodozyj, Matulenko, Mark A, Hakeem, Ahmed A, Patel, Meena V, Mortell, Kathleen, Bhatia, Pramila, Henry, Rodger, Nakane, Masaki, Hsieh, Gin C, Terranova, Marc A, Uchic, Marie E, Miller, Loan N, Chang, Renje, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Martino, Brenda, El Kouhen, Odile, Marsh, Kennan C, Wetter, Jill M, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Dopamine D4 Ligands and Models of Receptor Activation: 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning
Stewart, Andrew O, Cowart, Marlon D, Moreland, Robert B, Latshaw, Steve P, Matulenko, Mark A, Bhatia, Pramila A, Wang, Xueqing, Daanen, Jerome F, Nelson, Sherry L, Terranova, Marc A, Namovic, Marian T, Donnelly-Roberts, Diana L, Miller, Loan N, Nakane, Masaki, Sullivan, James P, Brioni, Jorge D
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
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Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives
Kort, Michael E., Atkinson, Robert N., Thomas, James B., Drizin, Irene, Johnson, Matthew S., Secrest, Matthew A., Gregg, Robert J., Scanio, Marc J.C., Shi, Lei, Hakeem, Ahmed H., Matulenko, Mark A., Chapman, Mark L., Krambis, Michael J., Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda, Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Werness, Stephen, Antonio, Brett, Marsh, Kennan C., Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F., Marron, Brian E.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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