Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells
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Published in Toxicology letters (01.01.2005)
Published in Toxicology letters (01.01.2005)
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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro‑2H‑pyrazolo[4,3‑c]quinoline (ELND007): Metabolically Stable γ‑Secretase Inhibitors that Selectively Inhibit the Production of Amyloid‑β over Notch
Probst, Gary, Aubele, Danielle L, Bowers, Simeon, Dressen, Darren, Garofalo, Albert W, Hom, Roy K, Konradi, Andrei W, Marugg, Jennifer L, Mattson, Matthew N, Neitzel, Martin L, Semko, Chris M, Sham, Hing L, Smith, Jenifer, Sun, Minghua, Truong, Anh P, Ye, Xiaocong M, Xu, Ying-zi, Dappen, Michael S, Jagodzinski, Jacek J, Keim, Pamela S, Peterson, Brian, Latimer, Lee H, Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K, Quinn, Kevin P, Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F, Kholodenko, Dora, Hu, Kang, Kwong, Grace T, Lee, Michael, Liao, Anna, Motter, Ruth N, Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P, Hemphill, Susanna S, Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A, Basi, Guriqbal S
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Discovery of sulfonamide–pyrazole γ-secretase inhibitors
Mattson, Matthew N., Neitzel, Martin L., Quincy, David A., Semko, Christopher M., Garofalo, Albert W., Keim, Pamela S., Konradi, Andrei W., Pleiss, Michael A., Sham, Hing L., Brigham, Elizabeth F., Goldbach, Erich G., Zhang, Hongbin, Sauer, John-Michael, Basi, Guriqbal S.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
Basi, Guriqbal S, Hemphill, Susanna, Brigham, Elizabeth F, Liao, Anna, Aubele, Danielle L, Baker, Jeanne, Barbour, Robin, Bova, Michael, Chen, Xiao-Hua, Dappen, Michael S, Eichenbaum, Tovah, Goldbach, Erich, Hawkinson, Jon, Lawler-Herbold, Rose, Hu, Kang, Hui, Terence, Jagodzinski, Jacek J, Keim, Pamela S, Kholodenko, Dora, Latimer, Lee H, Lee, Mike, Marugg, Jennifer, Mattson, Matthew N, McCauley, Scott, Miller, James L, Motter, Ruth, Mutter, Linda, Neitzel, Martin L, Ni, Huifang, Nguyen, Lan, Quinn, Kevin, Ruslim, Lany, Semko, Christopher M, Shapiro, Paul, Smith, Jenifer, Soriano, Ferdie, Szoke, Balazs, Tanaka, Kevin, Tang, Pearl, Tucker, John A, Ye, Xiacong Michael, Yu, Mei, Wu, Jing, Xu, Ying-Zi, Garofalo, Albert W, Sauer, John Michael, Konradi, Andrei W, Ness, Daniel, Shopp, George, Pleiss, Michael A, Freedman, Stephen B, Schenk, Dale
Published in Alzheimer's research & therapy (29.12.2010)
Published in Alzheimer's research & therapy (29.12.2010)
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Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors
Aubele, Danielle L., Truong, Anh P., Dressen, Darren B., Probst, Gary D., Bowers, Simeon, Mattson, Matthew N., Semko, Chris M., Sun, Minghua, Garofalo, Albert W., Konradi, Andrei W., Sham, Hing L., Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Bova, Michael P., Hemphill, Susanna S., Basi, Guriqbal
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase α is mediated by hydrogen peroxide
Bova, Michael P., Mattson, Matthew N., Vasile, Stefan, Tam, Danny, Holsinger, Leslie, Bremer, Meire, Hui, Terence, McMahon, Gerald, Rice, Audie, Fukuto, Jon M.
Published in Archives of biochemistry and biophysics (01.09.2004)
Published in Archives of biochemistry and biophysics (01.09.2004)
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Synthesis of Chiral Pilocarpine Analogues via a C-8 Ketone Intermediate
Holden, Kenneth G, Mattson, Matthew N, Cha, Kyung Hoi, Rapoport, Henry
Published in Journal of organic chemistry (23.08.2002)
Published in Journal of organic chemistry (23.08.2002)
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Discovery of ( R )-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and ( R )-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2 H -pyrazolo[4,3- c ]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch
Probst, Gary, Aubele, Danielle L., Bowers, Simeon, Dressen, Darren, Garofalo, Albert W., Hom, Roy K., Konradi, Andrei W., Marugg, Jennifer L., Mattson, Matthew N., Neitzel, Martin L., Semko, Chris M., Sham, Hing L., Smith, Jenifer, Sun, Minghua, Truong, Anh P., Ye, Xiaocong M., Xu, Ying-zi, Dappen, Michael S., Jagodzinski, Jacek J., Keim, Pamela S., Peterson, Brian, Latimer, Lee H., Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K., Quinn, Kevin P., Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F., Kholodenko, Dora, Hu, Kang, Kwong, Grace T., Lee, Michael, Liao, Anna, Motter, Ruth N., Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P., Hemphill, Susanna S., Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A., Basi, Guriqbal S.
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Improved one-flask preparations of cyclopropanation reagents: (.eta.5-C5H5)(CO)2FeCH2S(CH3)2+ BF4- and [.eta.5-C5(CH3)5](CO)2FeCH2S(CH3)2+ BF4
Mattson, Matthew N, Bays, J. Philip, Zakutansky, Julie, Stolarski, Victoria, Helquist, Paul
Published in Journal of organic chemistry (01.05.1989)
Published in Journal of organic chemistry (01.05.1989)
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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent [gamma]-secretase inhibitors
Aubele, Danielle L, Truong, Anh P, Dressen, Darren B, Probst, Gary D, Bowers, Simeon, Mattson, Matthew N, Semko, Chris M, Sun, Minghua, Garofalo, Albert W, Konradi, Andrei W, Sham, Hing L, Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P, Sauer, John-Michael, Brigham, Elizabeth F, Wallace, William, Nguyen, Lan, Bova, Michael P, Hemphill, Susanna S, Basi, Guriqbal
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Pyridonyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
Glick, Gary D, Taylor, Clarke B, Vanhuis, Chad A, Hurd, Alexander R, Mattson, Matthew N
Year of Publication 27.10.2016
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Year of Publication 27.10.2016
Patent
Pyridonyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
TAYLOR CLARKE B, GLICK GARY D, MATTSON MATTHEW N, VAN HUIS CHAD A, HURD ALEXANDER R
Year of Publication 21.06.2016
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Year of Publication 21.06.2016
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PYRIDONYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF
HURD, ALEXANDER, R, TAYLOR, CLARKE, B, GLICK, GARY, D, VANHUIS, CHAD, A, MATTSON, MATTHEW, N
Year of Publication 15.06.2016
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Year of Publication 15.06.2016
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Mechanistic test for carbocationic alkene cyclization initiated by cationic iron carbene complex formation
Baker, Christopher T., Mattson, Matthew N., Helquist, Paul
Published in Tetrahedron letters (25.09.1995)
Published in Tetrahedron letters (25.09.1995)
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PYRIDONYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF
TAYLOR CLARKE B, GLICK GARY D, MATTSON MATTHEW N, VAN HUIS CHAD A, HURD ALEXANDER R
Year of Publication 26.11.2015
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Year of Publication 26.11.2015
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Pyridonyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
TAYLOR CLARKE B, GLICK GARY D, MATTSON MATTHEW N, VAN HUIS CHAD A, HURD ALEXANDER R
Year of Publication 07.04.2015
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Year of Publication 07.04.2015
Patent
PYRIDONYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF
HURD, ALEXANDER, R, TAYLOR, CLARKE, B, GLICK, GARY, D, VANHUIS, CHAD, A, MATTSON, MATTHEW, N
Year of Publication 02.04.2014
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Year of Publication 02.04.2014
Patent