Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease
Bürli, Roland W, Luckhurst, Christopher A, Aziz, Omar, Matthews, Kim L, Yates, Dawn, Lyons, Kathy. A, Beconi, Maria, McAllister, George, Breccia, Perla, Stott, Andrew J, Penrose, Stephen D, Wall, Michael, Lamers, Marieke, Leonard, Philip, Müller, Ilka, Richardson, Christine M, Jarvis, Rebecca, Stones, Liz, Hughes, Samantha, Wishart, Grant, Haughan, Alan F, O’Connell, Catherine, Mead, Tania, McNeil, Hannah, Vann, Julie, Mangette, John, Maillard, Michel, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease
Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors
Luckhurst, Christopher A, Breccia, Perla, Stott, Andrew J, Aziz, Omar, Birch, Helen L, Bürli, Roland W, Hughes, Samantha J, Jarvis, Rebecca E, Lamers, Marieke, Leonard, Philip M, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for Parkinson's Disease
Margolin, David H, Brice, Nicola L, Davidson, Antonia M, Matthews, Kim L, Carlton, Mark B L
Published in The Journal of pharmacology and experimental therapeutics (01.04.2022)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2022)
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Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate
Westaway, Susan M, Brown, Samantha L, Fell, Stephen C. M, Johnson, Christopher N, MacPherson, David T, Mitchell, Darren J, Myatt, James W, Stanway, Steven J, Seal, Jon T, Stemp, Geoffrey, Thompson, Mervyn, Lawless, Kirk, McKay, Fiona, Muir, Alison I, Barford, Jonathan M, Cluff, Chermaine, Mahmood, Sadhia R, Matthews, Kim L, Mohamed, Shiyam, Smith, Beverley, Stevens, Alexander J, Bolton, Victoria J, Jarvie, Emma M, Sanger, Gareth J
Published in Journal of medicinal chemistry (26.02.2009)
Published in Journal of medicinal chemistry (26.02.2009)
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Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington’s Disease
Van de Poël, Amanda, Toledo-Sherman, Leticia, Breccia, Perla, Cachope, Roger, Bate, Jennifer R, Angulo-Herrera, Ivan, Wishart, Grant, Matthews, Kim L, Martin, Sarah L, Peacock, Marcus, Barnard, Amy, Cox, Helen C, Jones, Graham, McAllister, George, Vater, Huw, Esmieu, William, Clissold, Cole, Lamers, Marieke, Leonard, Philip, Jarvis, Rebecca E, Blackaby, Wesley, Eznarriaga, Maria, Lazari, Ovadia, Yates, Dawn, Rose, Mark, Jang, Sung-Wook, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor
Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Bürli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington’s Disease Models
Toledo-Sherman, Leticia, Breccia, Perla, Cachope, Roger, Bate, Jennifer R, Angulo-Herrera, Ivan, Wishart, Grant, Matthews, Kim L, Martin, Sarah L, Cox, Helen C, McAllister, George, Penrose, Stephen D, Vater, Huw, Esmieu, William, Van de Poël, Amanda, Van de Bospoort, Rhea, Strijbosch, Annelieke, Lamers, Marieke, Leonard, Philip, Jarvis, Rebecca E, Blackaby, Wesley, Barnes, Karen, Eznarriaga, Maria, Dowler, Simon, Smith, Graham D, Fischer, David F, Lazari, Ovadia, Yates, Dawn, Rose, Mark, Jang, Sung-Wook, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.03.2019)
Published in Journal of medicinal chemistry (28.03.2019)
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Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain
Myatt, James W., Healy, Mark P., Bravi, Gianpaolo S., Billinton, Andrew, Johnson, Christopher N., Matthews, Kim L., Jandu, Karamjit S., Meng, Wenjing, Hersey, Anne, Livermore, David G., Douault, Clement B., Witherington, Jason, Bit, Rino A., Rowedder, James E., Brown, Jason D., Clayton, Nick M.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor
Bailey, James M., Scott, Jackie S., Basilla, Jonathan B., Bolton, Victoria J., Boyfield, Izzy, Evans, David G., Fleury, Etienne, Heightman, Tom D., Jarvie, Emma M., Lawless, Kirk, Matthews, Kim L., McKay, Fiona, Mok, Hindy, Muir, Alison, Orlek, Barry S., Sanger, Gareth J., Stemp, Geoffrey, Stevens, Alexander J., Thompson, Mervyn, Ward, John, Vaidya, Kalindi, Westaway, Susan M.
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
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The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor
Westaway, Susan M., Brown, Samantha L., Conway, Elizabeth, Heightman, Tom D., Johnson, Christopher N., Lapsley, Kate, Macdonald, Gregor J., MacPherson, David T., Mitchell, Darren J., Myatt, James W., Seal, Jon T., Stanway, Steven J., Stemp, Geoffrey, Thompson, Mervyn, Celestini, Paolo, Colombo, Andrea, Consonni, Alessandra, Gagliardi, Stefania, Riccaboni, Mauro, Ronzoni, Silvano, Briggs, Michael A., Matthews, Kim L., Stevens, Alexander J., Bolton, Victoria J., Boyfield, Izzy, Jarvie, Emma M., Stratton, Sharon C., Sanger, Gareth J.
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class Ha histone deacetylase inhibitor
Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Burli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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Journal Article
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease
Stott, Andrew J., Maillard, Michel C., Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H., Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F., Jarvis, Rebecca E., Luckhurst, Christopher A., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poel, Amanda J., Vater, Huw D., Vann, Julie, Williams, Rachel, Yates, Dawn, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class Ila Histone Deacetylase (HDAC) Inhibitors
Luckhurst, Christopher A., Breccia, Perla, Stott, Andrew J., Aziz, Omar, Birch, Helen L., Buerli, Roland W., Hughes, Samantha J., Jarvis, Rebecca E., Lamers, Marieke, Leonard, Philip M., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in ACS medicinal chemistry letters (01.01.2016)
Published in ACS medicinal chemistry letters (01.01.2016)
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Journal Article
Discovery of N-(3-Fluorophenyl)-1-[4-([(3S)-3-methyl-1-piperazinyl]methyl)phenylacetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate
WESTAWAY, Susan M, BROWN, Samantha L, THOMPSON, Mervyn, LAWLESS, Kirk, MCKAY, Fiona, MUIR, Alison I, BARFORD, Jonathan M, CLUFF, Chermaine, MAHMOOD, Sadhia R, MATTHEWS, Kim L, MOHAMED, Shiyam, SMITH, Beverley, FELL, Stephen C. M, STEVENS, Alexander J, BOLTON, Victoria J, JARVIE, Emma M, SANGER, Gareth J, JOHNSON, Christopher N, MACPHERSON, David T, MITCHELL, Darren J, MYATT, James W, STANWAY, Steven J, SEAL, Jon T, STEMP, Geoffrey
Published in Journal of medicinal chemistry (2009)
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Published in Journal of medicinal chemistry (2009)
Journal Article
Noradrenergic changes and aggressive behaviour in patients with dementia
Matthews, Kim L., l-H Chen, Christopher P., Esiri, Margaret M., Keene, Janet, Minger, Stephen L., Francis, Paul T.
Published in Neurobiology of aging (01.05.2000)
Published in Neurobiology of aging (01.05.2000)
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