Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
Varcianna, André, Myszczynska, Monika A., Castelli, Lydia M., O'Neill, Brendan, Kim, Yeseul, Talbot, Jordan, Nyberg, Sophie, Nyamali, Immanuelle, Heath, Paul R., Stopford, Matthew J., Hautbergue, Guillaume M., Ferraiuolo, Laura
Published in EBioMedicine (01.02.2019)
Published in EBioMedicine (01.02.2019)
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SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
Hautbergue, Guillaume M., Castelli, Lydia M., Ferraiuolo, Laura, Sanchez-Martinez, Alvaro, Cooper-Knock, Johnathan, Higginbottom, Adrian, Lin, Ya-Hui, Bauer, Claudia S., Dodd, Jennifer E., Myszczynska, Monika A., Alam, Sarah M., Garneret, Pierre, Chandran, Jayanth S., Karyka, Evangelia, Stopford, Matthew J., Smith, Emma F., Kirby, Janine, Meyer, Kathrin, Kaspar, Brian K., Isaacs, Adrian M., El-Khamisy, Sherif F., De Vos, Kurt J., Ning, Ke, Azzouz, Mimoun, Whitworth, Alexander J., Shaw, Pamela J.
Published in Nature communications (05.07.2017)
Published in Nature communications (05.07.2017)
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MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis
Glajch, Kelly E, Ferraiuolo, Laura, Mueller, Kaly A, Stopford, Matthew J, Prabhkar, Varsha, Gravanis, Achille, Shaw, Pamela J, Sadri-Vakili, Ghazaleh
Published in PloS one (07.10.2016)
Published in PloS one (07.10.2016)
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C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten
Stopford, Matthew J, Higginbottom, Adrian, Hautbergue, Guillaume M, Cooper-Knock, Johnathan, Mulcahy, Padraig J, De Vos, Kurt J, Renton, Alan E, Pliner, Hannah, Calvo, Andrea, Chio, Adriano, Traynor, Bryan J, Azzouz, Mimoun, Heath, Paul R, Kirby, Janine, Shaw, Pamela J
Published in Human molecular genetics (15.03.2017)
Published in Human molecular genetics (15.03.2017)
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Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy
Cooper-Knock, Johnathan, Higginbottom, Adrian, Stopford, Matthew J., Highley, J. Robin, Ince, Paul G., Wharton, Stephen B., Pickering-Brown, Stuart, Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
Published in Acta neuropathologica (01.07.2015)
Published in Acta neuropathologica (01.07.2015)
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Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
Allen, Scott P, Hall, Benjamin, Castelli, Lydia M, Francis, Laura, Woof, Ryan, Siskos, Alexandros P, Kouloura, Eirini, Gray, Elizabeth, Thompson, Alexander G, Talbot, Kevin, Higginbottom, Adrian, Myszczynska, Monika, Allen, Chloe F, Stopford, Matthew J, Hemingway, Jordan, Bauer, Claudia S, Webster, Christopher P, De Vos, Kurt J, Turner, Martin R, Keun, Hector C, Hautbergue, Guillaume M, Ferraiuolo, Laura, Shaw, Pamela J
Published in Brain (London, England : 1878) (01.03.2019)
Published in Brain (London, England : 1878) (01.03.2019)
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Invited Review: Decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art
Walsh, Matthew J., Cooper-Knock, Johnathan, Dodd, Jennifer E., Stopford, Matthew J., Mihaylov, Simeon R., Kirby, Janine, Shaw, Pamela J., Hautbergue, Guillaume M.
Published in Neuropathology and applied neurobiology (01.02.2015)
Published in Neuropathology and applied neurobiology (01.02.2015)
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Inosine reverses motor neuron toxicity observed in amyotrophic lateral sclerosis patient astrocytes with an adenosine deaminase deficiency
Allen, Scott P., Hall, Benjamin, Castelli, Lydia, Francis, Laura, Woof, Ryan, Higginbottom, Adrian, Myszczynska, Monika, Allen, Chloe F., Stopford, Matthew J., Webster, Christopher P., De Vos, Kurt, Hautbergue, Guillaume M., Ferraiuolo, Laura, Shaw, Pamela J.
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2018)
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2018)
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Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALSResearch in context
André Varcianna, Monika A. Myszczynska, Lydia M. Castelli, Brendan O'Neill, Yeseul Kim, Jordan Talbot, Sophie Nyberg, Immanuelle Nyamali, Paul R. Heath, Matthew J. Stopford, Guillaume M. Hautbergue, Laura Ferraiuolo
Published in EBioMedicine (01.02.2019)
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Published in EBioMedicine (01.02.2019)
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