Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
Hassett, Kimberly J., Benenato, Kerry E., Jacquinet, Eric, Lee, Aisha, Woods, Angela, Yuzhakov, Olga, Himansu, Sunny, Deterling, Jessica, Geilich, Benjamin M., Ketova, Tatiana, Mihai, Cosmin, Lynn, Andy, McFadyen, Iain, Moore, Melissa J., Senn, Joseph J., Stanton, Matthew G., Almarsson, Örn, Ciaramella, Giuseppe, Brito, Luis A.
Published in Molecular therapy. Nucleic acids (15.04.2019)
Published in Molecular therapy. Nucleic acids (15.04.2019)
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Impact of mRNA chemistry and manufacturing process on innate immune activation
Nelson, Jennifer, Sorensen, Elizabeth W, Mintri, Shrutika, Rabideau, Amy E, Zheng, Wei, Besin, Gilles, Khatwani, Nikhil, Su, Stephen V, Miracco, Edward J, Issa, William J, Hoge, Stephen, Stanton, Matthew G, Joyal, John L
Published in Science advances (01.06.2020)
Published in Science advances (01.06.2020)
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5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates
Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
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Systematic chemical modifications of single stranded siRNAs significantly improved CTNNB1 mRNA silencing
Chang, Wonsuk, Pei, Yi, Guidry, Erin N., Zewge, Daniel, Parish, Craig A., Sherer, Edward C., DiMuzio, Jillian, Zhang, Hangchun, South, Victoria J., Strapps, Walter R., Sepp-Lorenzino, Laura, Colletti, Steven L., Stanton, Matthew G.
Published in Bioorganic & medicinal chemistry letters (15.09.2016)
Published in Bioorganic & medicinal chemistry letters (15.09.2016)
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Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry
Lee, Anita Y. H, Paweletz, Cloud P, Pollock, Roy M, Settlage, Robert E, Cruz, Jonathan C, Secrist, J. Paul, Miller, Thomas A, Stanton, Matthew G, Kral, Astrid M, Ozerova, Nicole D. S, Meng, Fanyu, Yates, Nathan A, Richon, Victoria, Hendrickson, Ronald C
Published in Journal of proteome research (01.12.2008)
Published in Journal of proteome research (01.12.2008)
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The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors
Hamblett, Christopher L., Methot, Joey L., Mampreian, Dawn M., Sloman, David L., Stanton, Matthew G., Kral, Astrid M., Fleming, Judith C., Cruz, Jonathan C., Chenard, Melissa, Ozerova, Nicole, Hitz, Anna M., Wang, Hongmei, Deshmukh, Sujal V., Nazef, Naim, Harsch, Andreas, Hughes, Bethany, Dahlberg, William K., Szewczak, Alex A., Middleton, Richard E., Mosley, Ralph T., Secrist, J. Paul, Miller, Thomas A.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
Sabnis, Staci, Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Ketova, Tatiana, Senn, Joseph J., Lynn, Andy, Bulychev, Alex, McFadyen, Iain, Chan, Joyce, Almarsson, Örn, Stanton, Matthew G., Benenato, Kerry E.
Published in Molecular therapy (06.06.2018)
Published in Molecular therapy (06.06.2018)
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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties
Sloman, David L., Noucti, Njamkou, Altman, Michael D., Chen, Dapeng, Mislak, Andrea C., Szewczak, Alexander, Hayashi, Mansuo, Warren, Lee, Dellovade, Tammy, Wu, Zhenhua, Marcus, Jacob, Walker, Deborah, Su, Hua-Poo, Edavettal, Suzanne C., Munshi, Sanjeev, Hutton, Michael, Nuthall, Hugh, Stanton, Matthew G.
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates
Sankaranarayanan, Sethu, Holahan, Marie A, Colussi, Dennis, Crouthamel, Ming-Chih, Devanarayan, Viswanath, Ellis, Joan, Espeseth, Amy, Gates, Adam T, Graham, Samuel L, Gregro, Allison R, Hazuda, Daria, Hochman, Jerome H, Holloway, Katharine, Jin, Lixia, Kahana, Jason, Lai, Ming-tain, Lineberger, Janet, McGaughey, Georgia, Moore, Keith P, Nantermet, Philippe, Pietrak, Beth, Price, Eric A, Rajapakse, Hemaka, Stauffer, Shaun, Steinbeiser, Melissa A, Seabrook, Guy, Selnick, Harold G, Shi, Xiao-Ping, Stanton, Matthew G, Swestock, John, Tugusheva, Katherine, Tyler, Keala X, Vacca, Joseph P, Wong, Jacky, Wu, Guoxin, Xu, Min, Cook, Jacquelynn J, Simon, Adam J
Published in The Journal of pharmacology and experimental therapeutics (01.01.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2009)
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“New” Catalysts for the Ester-Interchange Reaction: The Role of Alkali-Metal Alkoxide Clusters in Achieving Unprecedented Reaction Rates
Stanton, Matthew G, Allen, Cara B, Kissling, Rebecca M, Lincoln, Alice L, Gagné, Michel R
Published in Journal of the American Chemical Society (24.06.1998)
Published in Journal of the American Chemical Society (24.06.1998)
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Inside Cover: 5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates (ChemBioChem 11/2016)
Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
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Discovery of Isonicotinamide Derived β-Secretase Inhibitors: In Vivo Reduction of β-Amyloid
Stanton, Matthew G, Stauffer, Shaun R, Gregro, Alison R, Steinbeiser, Melissa, Nantermet, Philippe, Sankaranarayanan, Sethu, Price, Eric A, Wu, Guoxin, Crouthamel, Ming-Chih, Ellis, Joan, Lai, Ming-Tain, Espeseth, Amy S, Shi, Xiao-Ping, Jin, Lixia, Colussi, Dennis, Pietrak, Beth, Huang, Qian, Xu, Min, Simon, Adam J, Graham, Samuel L, Vacca, Joseph P, Selnick, Harold
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor
Methot, Joey L, Hoffman, Dawn Mampreian, Witter, David J, Stanton, Matthew G, Harrington, Paul, Hamblett, Christopher, Siliphaivanh, Phieng, Wilson, Kevin, Hubbs, Jed, Heidebrecht, Richard, Kral, Astrid M, Ozerova, Nicole, Fleming, Judith C, Wang, Hongmei, Szewczak, Alexander A, Middleton, Richard E, Hughes, Bethany, Cruz, Jonathan C, Haines, Brian B, Chenard, Melissa, Kenific, Candia M, Harsch, Andreas, Secrist, J. Paul, Miller, Thomas A
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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Fluorinated piperidine acetic acids as γ-secretase modulators
Stanton, Matthew G., Hubbs, Jed, Sloman, David, Hamblett, Christopher, Andrade, Paula, Angagaw, Minilik, Bi, Grace, Black, Regina M., Crispino, Jamie, Cruz, Jonathan C., Fan, Eric, Farris, Georgia, Hughes, Bethany L., Kenific, Candia M., Middleton, Richard E., Nikov, George, Sajonz, Peter, Shah, Sanjiv, Shomer, Nirah, Szewczak, Alexander A., Tanga, Flobert, Tudge, Matthew T., Shearman, Mark, Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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