Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines
Zessin, Matthes, Meleshin, Marat, Hilscher, Sebastian, Schiene-Fischer, Cordelia, Barinka, Cyril, Jung, Manfred, Schutkowski, Mike
Published in International journal of molecular sciences (01.04.2023)
Published in International journal of molecular sciences (01.04.2023)
Get full text
Journal Article
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity
Ibrahim, Hany S, Abdelsalam, Mohamed, Zeyn, Yanira, Zessin, Matthes, Mustafa, Al-Hassan M, Fischer, Marten A, Zeyen, Patrik, Sun, Ping, Bülbül, Emre F, Vecchio, Anita, Erdmann, Frank, Schmidt, Matthias, Robaa, Dina, Barinka, Cyril, Romier, Christophe, Schutkowski, Mike, Krämer, Oliver H, Sippl, Wolfgang
Published in International journal of molecular sciences (29.12.2021)
Published in International journal of molecular sciences (29.12.2021)
Get full text
Journal Article
Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds
Bülbül, Emre F, Robaa, Dina, Sun, Ping, Mahmoudi, Fereshteh, Melesina, Jelena, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang
Published in Pharmaceuticals (Basel, Switzerland) (01.07.2023)
Published in Pharmaceuticals (Basel, Switzerland) (01.07.2023)
Get full text
Journal Article
Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors
Bülbül, Emre F, Melesina, Jelena, Ibrahim, Hany S, Abdelsalam, Mohamed, Vecchio, Anita, Robaa, Dina, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang
Published in Molecules (Basel, Switzerland) (14.04.2022)
Published in Molecules (Basel, Switzerland) (14.04.2022)
Get full text
Journal Article
N4-(2-Amino-4-fluorophenyl)-N1-(3-{2-[2-(3-{[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino}propoxy)ethoxy]ethoxy}propyl)terephthalamide
Abdelsalam, Mohamed, Zessin, Matthes, Schmidt, Matthias, Schutkowski, Mike, Sippl, Wolfgang
Published in MolBank (21.11.2022)
Published in MolBank (21.11.2022)
Get full text
Journal Article
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells
Fischer, Marten A., Mustafa, Al-Hassan M., Hausmann, Kristin, Ashry, Ramy, Kansy, Anita G., Liebl, Magdalena C., Brachetti, Christina, Piée-Staffa, Andrea, Zessin, Matthes, Ibrahim, Hany S., Hofmann, Thomas G., Schutkowski, Mike, Sippl, Wolfgang, Krämer, Oliver H.
Published in Journal of advanced research (01.06.2024)
Published in Journal of advanced research (01.06.2024)
Get full text
Journal Article
Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors
Kutil, Zsófia, Mikešová, Jana, Zessin, Matthes, Meleshin, Marat, Nováková, Zora, Alquicer, Glenda, Kozikowski, Alan, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike
Published in ACS omega (26.11.2019)
Published in ACS omega (26.11.2019)
Get full text
Journal Article
Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms
Zessin, Matthes, Meleshin, Marat, Praetorius, Lucas, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike
Published in ACS chemical biology (17.06.2022)
Published in ACS chemical biology (17.06.2022)
Get full text
Journal Article
Development of New Inhibitors of HDAC1–3 Enzymes Aided by In Silico Design Strategies
Cheshmazar, Narges, Hemmati, Salar, Hamzeh-Mivehroud, Maryam, Sokouti, Babak, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang, Nozad Charoudeh, Hojjatollah, Dastmalchi, Siavoush
Published in Journal of chemical information and modeling (23.05.2022)
Published in Journal of chemical information and modeling (23.05.2022)
Get full text
Journal Article
One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity
Zessin, Matthes, Kutil, Zsófia, Meleshin, Marat, Nováková, Zora, Ghazy, Ehab, Kalbas, Diana, Marek, Martin, Romier, Christophe, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike
Published in Biochemistry (Easton) (03.12.2019)
Published in Biochemistry (Easton) (03.12.2019)
Get full text
Journal Article
IN/I[sup.4]-terephthalamide
Abdelsalam, Mohamed, Zessin, Matthes, Schmidt, Matthias, Schutkowski, Mike, Sippl, Wolfgang
Published in MolBank (01.11.2022)
Published in MolBank (01.11.2022)
Get full text
Journal Article
Continuous Histone Deacylase Activity Assays
Zessin, Matthes, Meleshin, Marat, Sippl, Wolfgang, Schutkowski, Mike
Published in Methods in molecular biology (Clifton, N.J.) (2023)
Published in Methods in molecular biology (Clifton, N.J.) (2023)
Get more information
Journal Article
Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties
Sun, Ping, Wang, Jing, Khan, Khadija S., Yang, Weiqin, Ng, Billy Wai-Lung, Ilment, Nikita, Zessin, Matthes, Bülbül, Emre F., Robaa, Dina, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Schutkowski, Mike, Cheng, Alfred Sze-Lok, Sippl, Wolfgang
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
Get full text
Journal Article
Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3‑Arylmercapto-Acylated Lysine Derivatives
Kalbas, Diana, Meleshin, Marat, Liebscher, Sandra, Zessin, Matthes, Melesina, Jelena, Schiene-Fischer, Cordelia, Bülbül, Emre Fatih, Bordusa, Frank, Sippl, Wolfgang, Schutkowski, Mike
Published in Biochemistry (Easton) (06.09.2022)
Published in Biochemistry (Easton) (06.09.2022)
Get full text
Journal Article
Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation
Cheshmazar, Narges, Hamzeh-Mivehroud, Maryam, Hemmati, Salar, Abolhasani, Hoda, Heidari, Fatemeh, Charoudeh, Hojjatollah Nozad, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang, Dastmalchi, Siavoush
Published in Future medicinal chemistry (2024)
Published in Future medicinal chemistry (2024)
Get more information
Journal Article
Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)–based fluorescence quencher
Zessin, Matthes, Meleshin, Marat, Simic, Zeljko, Kalbas, Diana, Arbach, Miriam, Gebhardt, Philip, Melesina, Jelena, Liebscher, Sandra, Bordusa, Frank, Sippl, Wolfgang, Barinka, Cyril, Schutkowski, Mike
Published in Bioorganic chemistry (01.12.2021)
Published in Bioorganic chemistry (01.12.2021)
Get full text
Journal Article
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells
Fischer, Marten A, Mustafa, Al-Hassan M, Hausmann, Kristin, Ashry, Ramy, Kansy, Anita G, Liebl, Magdalena C, Brachetti, Christina, Piee-Staffa, Andrea, Matthes Zessin, Ibrahim, Hany S, Hofmann, Thomas G, Schutkowski, Mike, Sippl, Wolfgang, Kramer, Oliver H
Published in bioRxiv (12.03.2023)
Published in bioRxiv (12.03.2023)
Get full text
Paper