Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer
SUN, Jessica D, QIAN LIU, HART, Charles P, JINGLI WANG, AHLUWALIA, Dharmendra, FERRARO, Damien, YAN WANG, DUAN, Jian-Xin, STEVE AMMONS, W, CURD, John G, MATTEUCCI, Mark D
Published in Clinical cancer research (01.02.2012)
Published in Clinical cancer research (01.02.2012)
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Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302
Meng, Fanying, Evans, James W, Bhupathi, Deepthi, Banica, Monica, Lan, Leslie, Lorente, Gustavo, Duan, Jian-Xin, Cai, Xiaohong, Mowday, Alexandra M, Guise, Christopher P, Maroz, Andrej, Anderson, Robert F, Patterson, Adam V, Stachelek, Gregory C, Glazer, Peter M, Matteucci, Mark D, Hart, Charles P
Published in Molecular cancer therapeutics (01.03.2012)
Published in Molecular cancer therapeutics (01.03.2012)
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Correction: Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer
Sun, Jessica D, Liu, Qian, Wang, Jingli, Ahluwalia, Dharmendra, Ferraro, Damien, Wang, Yan, Duan, Jian-Xin, Ammons, W Steve, Curd, John G, Matteucci, Mark D, Hart, Charles P
Published in Clinical cancer research (15.05.2024)
Published in Clinical cancer research (15.05.2024)
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Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models
Sun, Jessica D., Liu, Qian, Ahluwalia, Dharmendra, Ferraro, Damien J., Wang, Yan, Jung, Don, Matteucci, Mark D., Hart, Charles P.
Published in Cancer biology & therapy (02.04.2016)
Published in Cancer biology & therapy (02.04.2016)
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TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules
Liu, Qian, Sun, Jessica D., Wang, Jingli, Ahluwalia, Dharmendra, Baker, Amanda F., Cranmer, Lee D., Ferraro, Damien, Wang, Yan, Duan, Jian-Xin, Ammons, W. Steve, Curd, John G., Matteucci, Mark D., Hart, Charles P.
Published in Cancer chemotherapy and pharmacology (01.06.2012)
Published in Cancer chemotherapy and pharmacology (01.06.2012)
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Potent and Highly Selective Hypoxia-Activated Achiral Phosphoramidate Mustards as Anticancer Drugs
Duan, Jian-Xin, Jiao, Hailong, Kaizerman, Jacob, Stanton, Timothy, Evans, James W, Lan, Leslie, Lorente, Gustavo, Banica, Monica, Jung, Don, Wang, Jinwei, Ma, Huaiyu, Li, Xiaoming, Yang, Zhijian, Hoffman, Robert M, Ammons, W. Steve, Hart, Charles P, Matteucci, Mark
Published in Journal of medicinal chemistry (24.04.2008)
Published in Journal of medicinal chemistry (24.04.2008)
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Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
Meng, Fanying, Bhupathi, Deepthi, Sun, Jessica D, Liu, Qian, Ahluwalia, Dharmendra, Wang, Yan, Matteucci, Mark D, Hart, Charles P
Published in BMC cancer (21.05.2015)
Published in BMC cancer (21.05.2015)
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Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models
Sun, Jessica D, Ahluwalia, Dharmendra, Liu, Qian, Li, Wenwu, Wang, Yan, Meng, Fanying, Bhupathi, Deepthi, Matteucci, Mark D, Hart, Charles P
Published in American journal of cancer research (01.01.2015)
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Published in American journal of cancer research (01.01.2015)
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Potent Antitubulin Tumor Cell Cytotoxins Based on 3-Aroyl Indazoles
Duan, Jian-Xin, Cai, Xiaohong, Meng, Fanying, Lan, Leslie, Hart, Charles, Matteucci, Mark
Published in Journal of medicinal chemistry (08.03.2007)
Published in Journal of medicinal chemistry (08.03.2007)
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Metabolism, pharmacokinetics and excretion of a novel hypoxia activated cytotoxic prodrug, TH-302, in rats
Jung, Donald, Jiao, Hailong, Duan, Jian-Xi, Matteucci, Mark, Wang, Ronghua
Published in Xenobiotica (01.04.2012)
Published in Xenobiotica (01.04.2012)
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Laryngeal, laryngotracheal, and tracheal masses in cats: 27 cases (1998-2003)
Jakubiak, Martin J, Siedlecki, Cecile T, Zenger, Elisabeth, Matteucci, Mark L, Bruskiewicz, Kristine A, Rohn, Douglas A, Bergman, Philip J
Published in The Journal of the American Animal Hospital Association (01.09.2005)
Published in The Journal of the American Animal Hospital Association (01.09.2005)
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A Cytosine Analogue Capable of Clamp-Like Binding to a Guanine in Helical Nucleic Acids
Lin, Kuei-Ying, Matteucci, Mark D
Published in Journal of the American Chemical Society (26.08.1998)
Published in Journal of the American Chemical Society (26.08.1998)
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Current concepts in antisense drug design
Milligan, John F, Matteucci, Mark D, Martin, John C
Published in Journal of medicinal chemistry (09.07.1993)
Published in Journal of medicinal chemistry (09.07.1993)
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Nucleosides with a Twist. Can Fixed Forms of Sugar Ring Pucker Influence Biological Activity in Nucleosides and Oligonucleotides?
Marquez, Victor E, Siddiqui, Maqbool A, Ezzitouni, Abdallah, Russ, Pamela, Wang, Jianying, Wagner, Richard W, Matteucci, Mark D
Published in Journal of medicinal chemistry (13.09.1996)
Published in Journal of medicinal chemistry (13.09.1996)
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Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines
Wagner, Richard W., Matteucci, Mark D., Lewis, Jason G., Gutierrez, Arnold J., Moulds, Courtney, Froehler, Brian C.
Published in Science (American Association for the Advancement of Science) (04.06.1993)
Published in Science (American Association for the Advancement of Science) (04.06.1993)
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Pheochromocytoma in dogs: 61 cases (1984-1995)
Barthez, P.Y, Marks, S.L, Woo, J, Feldman, E.C, Matteucci, M
Published in Journal of veterinary internal medicine (01.09.1997)
Published in Journal of veterinary internal medicine (01.09.1997)
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Potent and selective inhibition of gene expression by an antisense heptanucleotide
Wagner, Richard W, Matteucci, Mark D, Grant, Deborah, Huang, Teresa, Froehler, Brian C
Published in Nature biotechnology (01.07.1996)
Published in Nature biotechnology (01.07.1996)
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Cellular penetration and antisense activity by a phenoxazine-substituted heptanucleotide
Flanagan, W. Michael, Matteucci, Mark D, Wagner, Richard W, Grant, Deborah, Lin, Kuei-Ying
Published in Nature biotechnology (01.01.1999)
Published in Nature biotechnology (01.01.1999)
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