Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging
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Published in Traffic (Copenhagen, Denmark) (01.05.2024)
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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
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Published in Brain (London, England : 1878) (01.01.2011)
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Alzheimer's-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition
Jiang, Ying, Mullaney, Kerry A, Peterhoff, Corrinne M, Che, Shaoli, Schmidt, Stephen D, Boyer-Boiteau, Anne, Ginsberg, Stephen D, Cataldo, Anne M, Mathews, Paul M, Nixon, Ralph A
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Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2010)
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Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Radde, Rebecca, Bolmont, Tristan, Kaeser, Stephan A, Coomaraswamy, Janaky, Lindau, Dennis, Stoltze, Lars, Calhoun, Michael E, Jäggi, Fabienne, Wolburg, Hartwig, Gengler, Simon, Haass, Christian, Ghetti, Bernardino, Czech, Christian, Hölscher, Christian, Mathews, Paul M, Jucker, Mathias
Published in EMBO reports (01.09.2006)
Published in EMBO reports (01.09.2006)
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The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
Nuriel, Tal, Peng, Katherine Y, Ashok, Archana, Dillman, Allissa A, Figueroa, Helen Y, Apuzzo, Justin, Ambat, Jayanth, Levy, Efrat, Cookson, Mark R, Mathews, Paul M, Duff, Karen E
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Published in Frontiers in neuroscience (12.12.2017)
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Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF
Jiang, Ying, Rigoglioso, Andrew, Peterhoff, Corrinne M, Pawlik, Monika, Sato, Yutaka, Bleiwas, Cynthia, Stavrides, Philip, Smiley, John F, Ginsberg, Stephen D, Mathews, Paul M, Levy, Efrat, Nixon, Ralph A
Published in Neurobiology of aging (01.03.2016)
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Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
Trinchese, Fabrizio, Fa', Mauro, Liu, Shumin, Zhang, Hong, Hidalgo, Ariel, Schmidt, Stephen D, Yamaguchi, Hisako, Yoshii, Narihiko, Mathews, Paul M, Nixon, Ralph A, Arancio, Ottavio
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Published in The Journal of clinical investigation (01.08.2008)
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Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice
Trinchese, Fabrizio, Liu, Shumin, Battaglia, Fortunato, Walter, Sean, Mathews, Paul M., Arancio, Ottavio
Published in Annals of neurology (01.06.2004)
Published in Annals of neurology (01.06.2004)
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The in Vivo Brain Interactome of the Amyloid Precursor Protein
Bai, Yu, Markham, Kelly, Chen, Fusheng, Weerasekera, Rasanjala, Watts, Joel, Horne, Patrick, Wakutani, Yosuke, Bagshaw, Rick, Mathews, Paul M., Fraser, Paul E., Westaway, David, St. George-Hyslop, Peter, Schmitt-Ulms, Gerold
Published in Molecular & cellular proteomics (01.01.2008)
Published in Molecular & cellular proteomics (01.01.2008)
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Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S., Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D., Wesson, Daniel W., Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M., Yang, Austin J., Wilson, Donald A., St. George-Hyslop, Peter, Westaway, David, Mathews, Paul M., Levy, Efrat, Cuervo, Ana Maria, Nixon, Ralph A.
Published in Autophagy (01.07.2011)
Published in Autophagy (01.07.2011)
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Brain apolipoprotein E levels in mice challenged by a Western diet increase in an allele-dependent manner
Liemisa, Braison, Newbury, Samantha F, Novy, Mariah J, Pasato, Jonathan A, Morales-Corraliza, Jose, Peng, Katherine Y, Mathews, Paul M
Published in Aging brain (01.01.2023)
Published in Aging brain (01.01.2023)
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Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model
Choi, Jennifer H.K, Berger, Jason D, Mazzella, Matthew J, Morales-Corraliza, Jose, Cataldo, Anne M, Nixon, Ralph A, Ginsberg, Stephen D, Levy, Efrat, Mathews, Paul M
Published in Journal of neurochemistry (01.09.2009)
Published in Journal of neurochemistry (01.09.2009)
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Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
Coomaraswamy, Janaky, Kilger, Ellen, Wölfing, Heidrun, Schäfer, Claudia, Kaeser, Stephan A, Wegenast-Braun, Bettina M, Hefendehl, Jasmin K, Wolburg, Hartwig, Mazzella, Matthew, Ghiso, Jorge, Goedert, Michel, Akiyama, Haruhiko, Garcia-Sierra, Francisco, Wolfer, David P, Mathews, Paul M, Jucker, Mathias
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2010)
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In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice
Morales-Corraliza, Jose, Mazzella, Matthew J, Berger, Jason D, Diaz, Nicole S, Choi, Jennifer H K, Levy, Efrat, Matsuoka, Yasuji, Planel, Emmanuel, Mathews, Paul M
Published in PloS one (22.09.2009)
Published in PloS one (22.09.2009)
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In vivo Reduction of Amyloid-β by a Mutant Copper Transporter
Phinney, Amie L., Drisaldi, Bettina, Schmidt, Stephen D., Lugowski, Stan, Coronado, Veronica, Liang, Yan, Horne, Patrick, Yang, Jing, Sekoulidis, Joannis, Coomaraswamy, Janaky, Chishti, M. Azhar, Cox, Diane W., Mathews, Paul M., Nixon, Ralph A., Carlson, George A., St George-Hyslop, Peter, Westaway, David
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2003)
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Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology
CATALDO, ANNE M, PETERHOFF, CORRINNE M, SCHMIDT, STEPHEN D, TERIO, NICOLE B, DUFF, KAREN, BEARD, MARGARET, MATHEWS, PAUL M, NIXON, RALPH A
Published in Journal of neuropathology and experimental neurology (01.08.2004)
Published in Journal of neuropathology and experimental neurology (01.08.2004)
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Apolipoprotein E4 genotype compromises brain exosome production
Peng, Katherine Y, Pérez-González, Rocío, Alldred, Melissa J, Goulbourne, Chris N, Morales-Corraliza, Jose, Saito, Mariko, Saito, Mitsuo, Ginsberg, Stephen D, Mathews, Paul M, Levy, Efrat
Published in Brain (London, England : 1878) (01.01.2019)
Published in Brain (London, England : 1878) (01.01.2019)
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