Search Results - "Matassa, Victor G" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease

The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease

by Ontoria, Jesus M, Di Marco, Stefania, Conte, Immacolata, Di Francesco, M. Emilia, Gardelli, Cristina, Koch, Uwe, Matassa, Victor G, Poma, Marco, Steinkühler, Christian, Volpari, Cinzia, Harper, Steven
Published in Journal of medicinal chemistry (16.12.2004)

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4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

by Summa, Vincenzo, Petrocchi, Alessia, Matassa, Victor G, Gardelli, Cristina, Muraglia, Ester, Rowley, Michael, Paz, Odalys Gonzalez, Laufer, Ralph, Monteagudo, Edith, Pace, Paola
Published in Journal of medicinal chemistry (16.11.2006)

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Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase

Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase

by Summa, Vincenzo, Petrocchi, Alessia, Pace, Paola, Matassa, Victor G, De Francesco, Raffaele, Altamura, Sergio, Tomei, Licia, Koch, Uwe, Neuner, Philippe
Published in Journal of medicinal chemistry (01.01.2004)

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From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety

From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety

by Petrocchi, Alessia, Koch, Uwe, Matassa, Victor G., Pacini, Barbara, Stillmock, Kara A., Summa, Vincenzo
Published in Bioorganic & medicinal chemistry letters (15.01.2007)

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HCV NS5b RNA-Dependent RNA Polymerase Inhibitors: From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and Synthesis

HCV NS5b RNA-Dependent RNA Polymerase Inhibitors: From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and Synthesis

by Summa, Vincenzo, Petrocchi, Alessia, Matassa, Victor G, Taliani, Marina, Laufer, Ralph, De Francesco, Raffaele, Altamura, Sergio, Pace, Paola
Published in Journal of medicinal chemistry (21.10.2004)

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2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery, SAR, Modeling, and Mutagenesis

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery, SAR, Modeling, and Mutagenesis

by Koch, Uwe, Attenni, Barbara, Malancona, Savina, Colarusso, Stefania, Conte, Immacolata, Di Filippo, Marcello, Harper, Steven, Pacini, Barbara, Giomini, Claudia, Thomas, Steven, Incitti, Ilario, Tomei, Licia, De Francesco, Raffaele, Altamura, Sergio, Matassa, Victor G, Narjes, Frank
Published in Journal of medicinal chemistry (09.03.2006)

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Controlled Modification of Acidity in Cholecystokinin B Receptor Antagonists: N-(1,4-Benzodiazepin-3-yl)-N ‘-[3-(tetrazol-5-ylamino)phenyl]ureas

Controlled Modification of Acidity in Cholecystokinin B Receptor Antagonists: N-(1,4-Benzodiazepin-3-yl)-N ‘-[3-(tetrazol-5-ylamino)phenyl]ureas

by Castro, José L, Ball, Richard G, Broughton, Howard B, Russell, Michael G. N, Rathbone, Denise, Watt, Alan P, Baker, Raymond, Chapman, Kerry L, Fletcher, Alan E, Patel, Smita, Smith, Alison J, Marshall, George R, Ryecroft, Wayne, Matassa, Victor G
Published in Journal of medicinal chemistry (16.02.1996)

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A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

by Narjes, Frank, Koehler, Konrad F, Koch, Uwe, Gerlach, Benjamin, Colarusso, Stefania, Steinkühler, Christian, Brunetti, Mirko, Altamura, Sergio, De Francesco, Raffaele, Matassa, Victor G
Published in Bioorganic & medicinal chemistry letters (25.02.2002)

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The design of potent and selective inhibitors of DPP-4: Optimization of ADME properties by amide replacements

The design of potent and selective inhibitors of DPP-4: Optimization of ADME properties by amide replacements

by Nordhoff, Sonja, Bulat, Stephan, Cerezo-Gálvez, Silvia, Hill, Oliver, Hoffmann-Enger, Barbara, López-Canet, Meritxell, Rosenbaum, Claudia, Rummey, Christian, Thiemann, Meinolf, Matassa, Victor G., Edwards, Paul J., Feurer, Achim
Published in Bioorganic & medicinal chemistry letters (15.11.2009)

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Discovery of β-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV

Discovery of β-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV

by Nordhoff, Sonja, Cerezo-Gálvez, Silvia, Deppe, Holger, Hill, Oliver, López-Canet, Meritxell, Rummey, Christian, Thiemann, Meinolf, Matassa, Victor G., Edwards, Paul J., Feurer, Achim
Published in Bioorganic & medicinal chemistry letters (01.08.2009)

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From lead to preclinical candidate: Optimization of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV

From lead to preclinical candidate: Optimization of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV

by Nordhoff, Sonja, López-Canet, Meritxell, Hoffmann-Enger, Barbara, Bulat, Stephan, Cerezo-Gálvez, Silvia, Hill, Oliver, Rosenbaum, Claudia, Rummey, Christian, Thiemann, Meinolf, Matassa, Victor G., Edwards, Paul J., Feurer, Achim
Published in Bioorganic & medicinal chemistry letters (15.08.2009)

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Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors

Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors

by Street, Leslie J, Baker, Raymond, Castro, Jose L, Chambers, Mark S, Guiblin, Alexander R, Hobbs, Sarah C, Matassa, Victor G, Reeve, Austin J, Beer, Margaret S
Published in Journal of medicinal chemistry (01.05.1993)

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The reversed binding of β-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors

The reversed binding of β-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors

by Nordhoff, Sonja, Cerezo-Gálvez, Silvia, Feurer, Achim, Hill, Oliver, Matassa, Victor G., Metz, Günther, Rummey, Christian, Thiemann, Meinolf, Edwards, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)

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Hepatitis C Virus Serine Protease Inhibitors: Current Progress and Future Challenges

Hepatitis C Virus Serine Protease Inhibitors: Current Progress and Future Challenges

by STEINKÜHLER, Christian, KOCH, Uwe, NARJES, Frank, MATASSA, Victor G
Published in Current medicinal chemistry (01.07.2001)

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Capped dipeptide α-Ketoacid inhibitors of the HCV NS3 protease

Capped dipeptide α-Ketoacid inhibitors of the HCV NS3 protease

by Nizi, Emanuela, Koch, Uwe, Ponzi, Simona, Matassa, Victor G, Gardelli, Cristina
Published in Bioorganic & medicinal chemistry letters (18.11.2002)

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Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures

Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures

by Orvieto, Federica, Koch, Uwe, Matassa, Victor G., Muraglia, Ester
Published in Bioorganic & medicinal chemistry letters (18.08.2003)

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Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease

Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease

by Colarusso, Stefania, Gerlach, Benjamin, Koch, Uwe, Muraglia, Ester, Conte, Immacolata, Stansfield, Ian, Matassa, Victor G, Narjes, Frank
Published in Bioorganic & medicinal chemistry letters (25.02.2002)

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α-Ketoacids Are Potent Slow Binding Inhibitors of the Hepatitis C Virus NS3 Protease

α-Ketoacids Are Potent Slow Binding Inhibitors of the Hepatitis C Virus NS3 Protease

by Narjes, Frank, Brunetti, Mirko, Colarusso, Stefania, Gerlach, Benjamin, Koch, Uwe, Biasiol, Gabriella, Fattori, Daniela, De Francesco, Raffaele, Matassa, Victor G, Steinkühler, Christian
Published in Biochemistry (Easton) (22.02.2000)

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Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease

Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease

by NIZI, Emanuela, KOCH, Uwe, ONTORIA, Jesus M, MARCHETTI, Antonella, NARJES, Frank, MALANCONA, Savina, MATASSA, Victor G, GARDELLI, Cristina
Published in Bioorganic & medicinal chemistry letters (03.05.2004)

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Phenethyl Amides as Novel Noncovalent Inhibitors of Hepatitis C Virus NS3/4A Protease: Discovery, Initial SAR, and Molecular Modeling

Phenethyl Amides as Novel Noncovalent Inhibitors of Hepatitis C Virus NS3/4A Protease: Discovery, Initial SAR, and Molecular Modeling

by Colarusso, Stefania, Koch, Uwe, Gerlach, Benjamin, Steinkühler, Christian, De Francesco, Raffaele, Altamura, Sergio, Matassa, Victor G, Narjes, Frank
Published in Journal of medicinal chemistry (30.01.2003)

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