A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids
Yamada, Shigeru, Masuno, Hiroyuki, Kagechika, Hiroyuki, Tanatani, Aya, Kanda, Yasunari
Published in Biological & pharmaceutical bulletin (01.11.2022)
Published in Biological & pharmaceutical bulletin (01.11.2022)
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A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment
Ishida, Ryosuke, Kurebayashi, Nagomi, Iinuma, Hiroto, Zeng, Xi, Mori, Shuichi, Kodama, Masami, Murayama, Takashi, Masuno, Hiroyuki, Takeda, Fumi, Kawahata, Masatoshi, Tanatani, Aya, Miura, Aya, Nishio, Hajime, Sakurai, Takashi, Kagechika, Hiroyuki
Published in European journal of medicinal chemistry (15.12.2023)
Published in European journal of medicinal chemistry (15.12.2023)
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Journal Article
Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists
Sasaki, Harue, Masuno, Hiroyuki, Kawasaki, Haru, Yoshihara, Ayana, Numoto, Nobutaka, Ito, Nobutoshi, Ishida, Hiroaki, Yamamoto, Keiko, Hirata, Naoya, Kanda, Yasunari, Kawachi, Emiko, Kagechika, Hiroyuki, Tanatani, Aya
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Journal Article
Structural Development of Silicon‐Containing Retinoids: Structure–Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities
Oikawa, Tsuyoshi, Fujii, Shinya, Mori, Shuichi, Masuno, Hiroyuki, Kawachi, Emiko, Kagechika, Hiroyuki
Published in ChemMedChem (20.06.2022)
Published in ChemMedChem (20.06.2022)
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Boron Cluster-based Development of Potent Nonsecosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane
Fujii, Shinya, Masuno, Hiroyuki, Taoda, Yoshiyuki, Kano, Atsushi, Wongmayura, Angsuma, Nakabayashi, Makoto, Ito, Nobutoshi, Shimizu, Masato, Kawachi, Emiko, Hirano, Tomoya, Endo, Yasuyuki, Tanatani, Aya, Kagechika, Hiroyuki
Published in Journal of the American Chemical Society (28.12.2011)
Published in Journal of the American Chemical Society (28.12.2011)
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Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C′-diphenylcarborane scaffold as a hydrophobic pharmacophore
Fujii, Shinya, Yamada, Ayumi, Nakano, Eiichi, Takeuchi, Yuki, Mori, Shuichi, Masuno, Hiroyuki, Kagechika, Hiroyuki
Published in European journal of medicinal chemistry (12.09.2014)
Published in European journal of medicinal chemistry (12.09.2014)
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Journal Article
Development of novel lithocholic acid derivatives as vitamin D receptor agonists
Masuno, Hiroyuki, Kazui, Yuko, Tanatani, Aya, Fujii, Shinya, Kawachi, Emiko, Ikura, Teikichi, Ito, Nobutoshi, Yamamoto, Keiko, Kagechika, Hiroyuki
Published in Bioorganic & medicinal chemistry (15.08.2019)
Published in Bioorganic & medicinal chemistry (15.08.2019)
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Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives
Masuno, Hiroyuki, Ikura, Teikichi, Morizono, Daisuke, Orita, Isamu, Yamada, Sachiko, Shimizu, Masato, Ito, Nobutoshi
Published in Journal of lipid research (01.08.2013)
Published in Journal of lipid research (01.08.2013)
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Journal Article
WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID
Sato, Atsushi, Shimizu, Masahiro, Goto, Toshiyasu, Masuno, Hiroyuki, Kagechika, Hiroyuki, Tanaka, Nobuyuki, Shibuya, Hiroshi
Published in Communications biology (12.11.2020)
Published in Communications biology (12.11.2020)
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Structural Development of Salicylanilide‐Based SPAK Inhibitors as Candidate Antihypertensive Agents
Fujii, Shinya, Kikuchi, Eriko, Suzuyama, Honoka, Watanabe, Yuko, Ishigami‐Yuasa, Mari, Masuno, Hiroyuki, Mori, Takayasu, Isobe, Kiyoshi, Uchida, Shinichi, Kagechika, Hiroyuki
Published in ChemMedChem (16.09.2021)
Published in ChemMedChem (16.09.2021)
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Journal Article
Development of p-carborane-based nonsteroidal progesterone receptor antagonists
Fujii, Shinya, Nakano, Eiichi, Yanagida, Naoki, Mori, Shuichi, Masuno, Hiroyuki, Kagechika, Hiroyuki
Published in Bioorganic & medicinal chemistry (01.10.2014)
Published in Bioorganic & medicinal chemistry (01.10.2014)
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Journal Article
Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists
Yoshihara, Ayana, Kawasaki, Haru, Masuno, Hiroyuki, Takada, Koki, Numoto, Nobutaka, Ito, Nobutoshi, Hirata, Naoya, Kanda, Yasunari, Ishizawa, Michiyasu, Makishima, Makoto, Kagechika, Hiroyuki, Tanatani, Aya
Published in Biomolecules (Basel, Switzerland) (14.01.2022)
Published in Biomolecules (Basel, Switzerland) (14.01.2022)
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Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia
Ishizawa, Michiyasu, Matsunawa, Manabu, Adachi, Ryutaro, Uno, Shigeyuki, Ikeda, Kazumasa, Masuno, Hiroyuki, Shimizu, Masato, Iwasaki, Ken-ichi, Yamada, Sachiko, Makishima, Makoto
Published in Journal of lipid research (01.04.2008)
Published in Journal of lipid research (01.04.2008)
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Journal Article
Synthesis and structure–activity relationship of p-carborane-based non-secosteroidal vitamin D analogs
Fujii, Shinya, Kano, Atsushi, Songkram, Chalermkiat, Masuno, Hiroyuki, Taoda, Yoshiyuki, Kawachi, Emiko, Hirano, Tomoya, Tanatani, Aya, Kagechika, Hiroyuki
Published in Bioorganic & medicinal chemistry (15.02.2014)
Published in Bioorganic & medicinal chemistry (15.02.2014)
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Journal Article
Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative
Adachi, Ryutaro, Honma, Yoshio, Masuno, Hiroyuki, Kawana, Katsuyoshi, Shimomura, Iichiro, Yamada, Sachiko, Makishima, Makoto
Published in Journal of lipid research (01.01.2005)
Published in Journal of lipid research (01.01.2005)
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Journal Article
Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetra- and Pentapeptide-Scaffolds Towards the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis
TAMAMURA, Hirokazu, TSUTSUMI, Hiroshi, MASUNO, Hiroyuki, FUJII, Nobutaka
Published in Current medicinal chemistry (01.01.2007)
Published in Current medicinal chemistry (01.01.2007)
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Structure-Function Analysis of Vitamin D 24-Hydroxylase (CYP24A1) by Site-Directed Mutagenesis: Amino Acid Residues Responsible for Species-Based Difference of CYP24A1 between Humans and Rats
Hamamoto, Hiromi, Kusudo, Tatsuya, Urushino, Naoko, Masuno, Hiroyuki, Yamamoto, Keiko, Yamada, Sachiko, Kamakura, Masaki, Ohta, Miho, Inouye, Kuniyo, Sakaki, Toshiyuki
Published in Molecular pharmacology (01.07.2006)
Published in Molecular pharmacology (01.07.2006)
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Journal Article
Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine−Zinc(II) Complex Structure
Tamamura, Hirokazu, Ojida, Akio, Ogawa, Teppei, Tsutsumi, Hiroshi, Masuno, Hiroyuki, Nakashima, Hideki, Yamamoto, Naoki, Hamachi, Itaru, Fujii, Nobutaka
Published in Journal of medicinal chemistry (01.06.2006)
Published in Journal of medicinal chemistry (01.06.2006)
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Journal Article
Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents
Tsutsumi, Hiroshi, Tanaka, Tomohiro, Ohashi, Nami, Masuno, Hiroyuki, Tamamura, Hirokazu, Hiramatsu, Kenichi, Araki, Takanobu, Ueda, Satoshi, Oishi, Shinya, Fujii, Nobutaka
Published in Biopolymers (2007)
Published in Biopolymers (2007)
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